Flavonoid intake and its association with atrial fibrillation

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  • Nicola P Bondonno, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia; School of Biomedical Sciences, The University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia; Institute for Global Food Security, Queen's University Belfast, Northern Ireland, UK. Electronic address: n.bondonno@ecu.edu.au., Australia
  • Kevin Murray, School of Population and Global Health, University of Western Australia, Crawley, Western Australia, Australia., Australia
  • Catherine P Bondonno, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia; School of Biomedical Sciences, The University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia., Australia
  • Joshua R Lewis, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia; School of Biomedical Sciences, The University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia., Australia
  • Kevin D Croft, School of Biomedical Sciences, The University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia., Australia
  • Cecilie Kyrø, Danish Cancer Society, Denmark
  • Gunnar Gislason, Department of Cardiology, Herlev & Gentofte University Hospital, Copenhagen, Denmark; The National Institute of Public Health, University of Southern Denmark, Odense, Denmark; The Danish Heart Foundation, Copenhagen, Denmark., Denmark
  • Anne Tjønneland, The Danish Cancer Society Research Centre, Copenhagen, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
  • Augustin Scalbert, Biostatistics Group, International Agency for Research on Cancer, Lyon, France., France
  • Aedín Cassidy, Institute for Global Food Security, Queen's University Belfast, Belfast, Northern Ireland., United Kingdom
  • Jonathan P Piccini, Duke Center for Atrial Fibrillation, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC, USA., United States
  • Kim Overvad
  • Jonathan M Hodgson, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia; School of Biomedical Sciences, The University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia., Australia
  • Frederik Dalgaard, Department of Cardiology, Herlev-Gentofte Hospital, University Hospital Copenhagen, Herlev Ringvej 75, Herlev, Denmark., Denmark

BACKGROUND & AIMS: Primary prevention of atrial fibrillation (AF) through behavioural and dietary modification is a critically important and unmet need. Flavonoids are bioactive dietary compounds with promising cardiovascular health benefits. Our aim was to investigate the association between flavonoid intake and clinically apparent AF.

METHODS: Baseline data from 55 613 participants of the Danish Diet, Cancer and Health Study, without AF, recruited between 1993 and 1997, were cross-linked with Danish nationwide registries. Total flavonoid and flavonoid subclass intakes were calculated from validated food frequency questionnaires using the Phenol-Explorer database. Associations between flavonoid intake and incident AF (first-time hospitalization or outpatient visit) were examined using restricted cubic splines based on Cox proportional hazards models.

RESULTS: During a median [IQR] follow-up of 21 [18-22] years, 7291 participants were diagnosed with AF. Total flavonoid intake was not statistically significantly associated with risk of incident AF in the whole cohort. However, compared to the lowest quintile, a total flavonoid intake of 1000 mg/day was associated with a lower risk of AF in smokers [0.86 (0.77, 0.96)] but not in non-smokers [0.96 (0.88, 1.06)], and a lower risk of AF in high alcohol consumers [>20 g/d: 0.84 (0.75, 0.95)] but not in low-to-moderate alcohol consumers [<20 g/d: 0.97 (0.89, 1.07)].

CONCLUSION: Intake of flavonoids was not significantly associated with a lower risk of incident AF. However, higher intakes of flavonoids may be beneficial for those at a higher risk of developing AF.

Original languageEnglish
JournalClinical Nutrition
Volume39
Issue12
Pages (from-to)3821-3828
ISSN0261-5614
DOIs
Publication statusPublished - Dec 2020

    Research areas

  • atrial fibrillation, cardiovascular disease, flavonoids, nutrition, primary prevention, prospective cohort study

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