TY - JOUR
T1 - Five-year Changes in Alcohol Intake and Risk of Atrial Fibrillation
T2 - A Danish Cohort Study
AU - Frederiksen, Tanja Charlotte
AU - Christiansen, Morten Krogh
AU - Benjamin, Emelia J
AU - Overvad, Kim
AU - Olsen, Anja
AU - Dahm, Christina Catherine
AU - Jensen, Henrik Kjærulf
N1 - © The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.
PY - 2023/8
Y1 - 2023/8
N2 - Aims: Alcohol intake is a well-established risk factor for atrial fibrillation (AF). However, evidence on the effects of changes in alcohol intake to primary AF prevention is sparse. The aim of this study was to examine the association between 5-year changes in alcohol intake and the risk of incident AF. Methods and results: This study was based on the Danish cohort study Diet, Cancer and Health. Lifestyle factors were assessed using questionnaires at a recruitment research examination and a second examination 5 years later. Diagnoses of AF and comorbidities were retrieved from the Danish National Patient Registry. 43 758 participants without prior AF were included. The median age was 61 (25th-75th percentile 58-66) years and 54% were female. Over a median follow-up time of 15.7 years, 5312 participants had incident AF (incidence rate 8.6/1000 person-years). Compared with stable intake, increases in alcohol intake to ≥21 drinks/week from ≤6.9 drinks/week (HR: 1.38, 95% CI: 1.09-1.72) or 14-20.9 drinks/week (HR: 1.27, 95% CI: 1.01-1.59) at baseline were associated with a higher risk of AF. In contrast, we did not observe a statistically significant association between reductions in alcohol intake and the risk of AF. Conclusion: A 5-year increase in alcohol intake was associated with a greater risk of AF compared with a stable low/moderate intake.
AB - Aims: Alcohol intake is a well-established risk factor for atrial fibrillation (AF). However, evidence on the effects of changes in alcohol intake to primary AF prevention is sparse. The aim of this study was to examine the association between 5-year changes in alcohol intake and the risk of incident AF. Methods and results: This study was based on the Danish cohort study Diet, Cancer and Health. Lifestyle factors were assessed using questionnaires at a recruitment research examination and a second examination 5 years later. Diagnoses of AF and comorbidities were retrieved from the Danish National Patient Registry. 43 758 participants without prior AF were included. The median age was 61 (25th-75th percentile 58-66) years and 54% were female. Over a median follow-up time of 15.7 years, 5312 participants had incident AF (incidence rate 8.6/1000 person-years). Compared with stable intake, increases in alcohol intake to ≥21 drinks/week from ≤6.9 drinks/week (HR: 1.38, 95% CI: 1.09-1.72) or 14-20.9 drinks/week (HR: 1.27, 95% CI: 1.01-1.59) at baseline were associated with a higher risk of AF. In contrast, we did not observe a statistically significant association between reductions in alcohol intake and the risk of AF. Conclusion: A 5-year increase in alcohol intake was associated with a greater risk of AF compared with a stable low/moderate intake.
KW - alcohol
KW - atrial fibrillation
KW - cohort
KW - lifestyle
KW - prevention
KW - Prevention
KW - Alcohol
KW - Lifestyle
KW - Atrial Fibrillation
UR - http://www.scopus.com/inward/record.url?scp=85151892251&partnerID=8YFLogxK
U2 - 10.1093/eurjpc/zwac293
DO - 10.1093/eurjpc/zwac293
M3 - Journal article
C2 - 36508613
SN - 2047-4873
VL - 30
SP - 1046
EP - 1053
JO - European Journal of Preventive Cardiology
JF - European Journal of Preventive Cardiology
IS - 11
ER -