Fine-mapping young-stock survival QTL on chromosome 6 in Nordic Red Dairy Cattle

Zexi Cai, Xiaoping Wu, Bo Thomsen, Goutam Sahana*

*Corresponding author for this work

Research output: Contribution to book/anthology/report/proceedingArticle in proceedingsResearchpeer-review

Abstract

A genome-wide association study was carried out for young-stock survival (YSS) in Nordic Red Dairy cattle. The de-regressed proofs for 3,078 bulls for YSS index and four component traits were analyzed. The 50k genotypes were imputed to whole genome sequence level using run7 1000 bull genome sequence data. A major QTL on chromosome 6 was identified with rs133470751 as the lead SNP with –log10(p value) equal to 47.02. The lead SNP is located in a gene desert. The postGWAS analysis for functional annotations of the variants and presence for structural variants in the QTL peak was evaluated for being causal factor.
Original languageDanish
Title of host publicationWCGALP 2022 Programme book
Number of pages4
PublisherWageningen Academic Publishers
Publication dateJul 2022
Publication statusPublished - Jul 2022
EventWorld Congress on Genetics Applied to Livestock Production - Rotterdam, Netherlands
Duration: 3 Jul 20228 Jul 2022
Conference number: 12
https://wcgalp.com/

Conference

ConferenceWorld Congress on Genetics Applied to Livestock Production
Number12
Country/TerritoryNetherlands
CityRotterdam
Period03/07/202208/07/2022
Internet address

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