FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis

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FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis. / Shamsi, Farnaz; Xue, Ruidan; Huang, Tian Lian; Lundh, Morten; Liu, Yang; Leiria, Luiz O; Lynes, Matthew D; Kempf, Elena; Wang, Chih-Hao; Sugimoto, Satoru; Nigro, Pasquale; Landgraf, Kathrin; Schulz, Tim; Li, Yiming; Emanuelli, Brice; Kothakota, Srinivas; Williams, Lewis T; Jessen, Niels; Pedersen, Steen Bønløkke; Böttcher, Yvonne; Blüher, Matthias; Körner, Antje; Goodyear, Laurie J; Mohammadi, Moosa; Kahn, C Ronald; Tseng, Yu-Hua.

In: Nature Communications, Vol. 11, No. 1, 1421, 2020.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Shamsi, F, Xue, R, Huang, TL, Lundh, M, Liu, Y, Leiria, LO, Lynes, MD, Kempf, E, Wang, C-H, Sugimoto, S, Nigro, P, Landgraf, K, Schulz, T, Li, Y, Emanuelli, B, Kothakota, S, Williams, LT, Jessen, N, Pedersen, SB, Böttcher, Y, Blüher, M, Körner, A, Goodyear, LJ, Mohammadi, M, Kahn, CR & Tseng, Y-H 2020, 'FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis', Nature Communications, vol. 11, no. 1, 1421. https://doi.org/10.1038/s41467-020-15055-9

APA

Shamsi, F., Xue, R., Huang, T. L., Lundh, M., Liu, Y., Leiria, L. O., Lynes, M. D., Kempf, E., Wang, C-H., Sugimoto, S., Nigro, P., Landgraf, K., Schulz, T., Li, Y., Emanuelli, B., Kothakota, S., Williams, L. T., Jessen, N., Pedersen, S. B., ... Tseng, Y-H. (2020). FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis. Nature Communications, 11(1), [1421]. https://doi.org/10.1038/s41467-020-15055-9

CBE

Shamsi F, Xue R, Huang TL, Lundh M, Liu Y, Leiria LO, Lynes MD, Kempf E, Wang C-H, Sugimoto S, Nigro P, Landgraf K, Schulz T, Li Y, Emanuelli B, Kothakota S, Williams LT, Jessen N, Pedersen SB, Böttcher Y, Blüher M, Körner A, Goodyear LJ, Mohammadi M, Kahn CR, Tseng Y-H. 2020. FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis. Nature Communications. 11(1):Article 1421. https://doi.org/10.1038/s41467-020-15055-9

MLA

Vancouver

Shamsi F, Xue R, Huang TL, Lundh M, Liu Y, Leiria LO et al. FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis. Nature Communications. 2020;11(1). 1421. https://doi.org/10.1038/s41467-020-15055-9

Author

Shamsi, Farnaz ; Xue, Ruidan ; Huang, Tian Lian ; Lundh, Morten ; Liu, Yang ; Leiria, Luiz O ; Lynes, Matthew D ; Kempf, Elena ; Wang, Chih-Hao ; Sugimoto, Satoru ; Nigro, Pasquale ; Landgraf, Kathrin ; Schulz, Tim ; Li, Yiming ; Emanuelli, Brice ; Kothakota, Srinivas ; Williams, Lewis T ; Jessen, Niels ; Pedersen, Steen Bønløkke ; Böttcher, Yvonne ; Blüher, Matthias ; Körner, Antje ; Goodyear, Laurie J ; Mohammadi, Moosa ; Kahn, C Ronald ; Tseng, Yu-Hua. / FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis. In: Nature Communications. 2020 ; Vol. 11, No. 1.

Bibtex

@article{68486b87089c4977ace8b6d708790650,
title = "FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis",
abstract = "Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue (BAT). Using high-throughput library screening of secreted peptides, we identify two fibroblast growth factors (FGF), FGF6 and FGF9, as potent inducers of UCP1 expression in adipocytes and preadipocytes. Surprisingly, this occurs through a mechanism independent of adipogenesis and involves FGF receptor-3 (FGFR3), prostaglandin-E2 and interaction between estrogen receptor-related alpha, flightless-1 (FLII) and leucine-rich-repeat-(in FLII)-interacting-protein-1 as a regulatory complex for UCP1 transcription. Physiologically, FGF6/9 expression in adipose is upregulated by exercise and cold in mice, and FGF9/FGFR3 expression in human neck fat is significantly associated with UCP1 expression. Loss of FGF9 impairs BAT thermogenesis. In vivo administration of FGF9 increases UCP1 expression and thermogenic capacity. Thus, FGF6 and FGF9 are adipokines that can regulate UCP1 through a transcriptional network that is dissociated from brown adipogenesis, and act to modulate systemic energy metabolism.",
author = "Farnaz Shamsi and Ruidan Xue and Huang, {Tian Lian} and Morten Lundh and Yang Liu and Leiria, {Luiz O} and Lynes, {Matthew D} and Elena Kempf and Chih-Hao Wang and Satoru Sugimoto and Pasquale Nigro and Kathrin Landgraf and Tim Schulz and Yiming Li and Brice Emanuelli and Srinivas Kothakota and Williams, {Lewis T} and Niels Jessen and Pedersen, {Steen B{\o}nl{\o}kke} and Yvonne B{\"o}ttcher and Matthias Bl{\"u}her and Antje K{\"o}rner and Goodyear, {Laurie J} and Moosa Mohammadi and Kahn, {C Ronald} and Yu-Hua Tseng",
year = "2020",
doi = "10.1038/s41467-020-15055-9",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis

AU - Shamsi, Farnaz

AU - Xue, Ruidan

AU - Huang, Tian Lian

AU - Lundh, Morten

AU - Liu, Yang

AU - Leiria, Luiz O

AU - Lynes, Matthew D

AU - Kempf, Elena

AU - Wang, Chih-Hao

AU - Sugimoto, Satoru

AU - Nigro, Pasquale

AU - Landgraf, Kathrin

AU - Schulz, Tim

AU - Li, Yiming

AU - Emanuelli, Brice

AU - Kothakota, Srinivas

AU - Williams, Lewis T

AU - Jessen, Niels

AU - Pedersen, Steen Bønløkke

AU - Böttcher, Yvonne

AU - Blüher, Matthias

AU - Körner, Antje

AU - Goodyear, Laurie J

AU - Mohammadi, Moosa

AU - Kahn, C Ronald

AU - Tseng, Yu-Hua

PY - 2020

Y1 - 2020

N2 - Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue (BAT). Using high-throughput library screening of secreted peptides, we identify two fibroblast growth factors (FGF), FGF6 and FGF9, as potent inducers of UCP1 expression in adipocytes and preadipocytes. Surprisingly, this occurs through a mechanism independent of adipogenesis and involves FGF receptor-3 (FGFR3), prostaglandin-E2 and interaction between estrogen receptor-related alpha, flightless-1 (FLII) and leucine-rich-repeat-(in FLII)-interacting-protein-1 as a regulatory complex for UCP1 transcription. Physiologically, FGF6/9 expression in adipose is upregulated by exercise and cold in mice, and FGF9/FGFR3 expression in human neck fat is significantly associated with UCP1 expression. Loss of FGF9 impairs BAT thermogenesis. In vivo administration of FGF9 increases UCP1 expression and thermogenic capacity. Thus, FGF6 and FGF9 are adipokines that can regulate UCP1 through a transcriptional network that is dissociated from brown adipogenesis, and act to modulate systemic energy metabolism.

AB - Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue (BAT). Using high-throughput library screening of secreted peptides, we identify two fibroblast growth factors (FGF), FGF6 and FGF9, as potent inducers of UCP1 expression in adipocytes and preadipocytes. Surprisingly, this occurs through a mechanism independent of adipogenesis and involves FGF receptor-3 (FGFR3), prostaglandin-E2 and interaction between estrogen receptor-related alpha, flightless-1 (FLII) and leucine-rich-repeat-(in FLII)-interacting-protein-1 as a regulatory complex for UCP1 transcription. Physiologically, FGF6/9 expression in adipose is upregulated by exercise and cold in mice, and FGF9/FGFR3 expression in human neck fat is significantly associated with UCP1 expression. Loss of FGF9 impairs BAT thermogenesis. In vivo administration of FGF9 increases UCP1 expression and thermogenic capacity. Thus, FGF6 and FGF9 are adipokines that can regulate UCP1 through a transcriptional network that is dissociated from brown adipogenesis, and act to modulate systemic energy metabolism.

U2 - 10.1038/s41467-020-15055-9

DO - 10.1038/s41467-020-15055-9

M3 - Journal article

C2 - 32184391

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 1421

ER -