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Fetal programming and Wilms tumor

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  • Julia E Heck, University of California, Los Angeles
  • ,
  • Di He, University of California, Los Angeles
  • ,
  • Carla Janzen, University of California, Los Angeles
  • ,
  • Noah Federman, University of California, Los Angeles
  • ,
  • Jorn Olsen
  • Beate Ritz, University of California, Los Angeles
  • ,
  • Johnni Hansen, Kræftens Bekæmpelse

Background The "fetal programming" hypothesis has been evaluated in many adult diseases including cancer, but not for Wilms tumor. Wilms tumor has been related to high birthweight, but little is known about other growth metrics such as a baby's birth length, ponderal index, or placenta size, which can shed additional light on growth patterns. Methods Results Cases of Wilms tumor (N = 217) were taken from the Danish Cancer Registry, and controls (N = 4340) were randomly selected from the Population Register and matched to cases by sex and age. Linkage to the Medical Births Registry provided information on gestational factors and fetal growth measurements, while linkage to the Patient Register provided information on maternal and child health conditions. Despite having typically normal to higher birthweights, Wilms tumor cases had smaller placentas (4000 g; OR = 1.57; 95% CI, 1.11-2.22), birth length 55 cm or longer (OR = 1.74; 95% CI, 1.09-2.78), and being large for gestational age (OR = 1.79; 95% CI, 1.08-2.96). Conclusions Our study corroborates earlier studies showing associations with high birthweight and suggests associations between Wilms tumor and decreased placental size and low placenta-to-birthweight ratio.

Original languageEnglish
Article numbere27461
JournalPediatric Blood & Cancer
Number of pages11
Publication statusPublished - Jan 2019

    Research areas

  • birthweight, body size, fetal development, nephroblastoma, placenta

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