TY - JOUR
T1 - Fetal Heart Defects and Measures of Cerebral Size
AU - Lauridsen, Mette Høj
AU - Uldbjerg, Niels
AU - Petersen, Olav Bjørn
AU - Vestergaard, Else Marie
AU - Matthiesen, Niels Bjerregaard
AU - Henriksen, Tine Brink
AU - Østergaard, John Rosendahl
AU - Hjortdal, Vibeke Elisabeth
N1 - Copyright © 2019 Elsevier Inc. All rights reserved.
PY - 2019
Y1 - 2019
N2 - OBJECTIVES: To estimate the association between fetal congenital heart defects (CHDs) and measures of brain size throughout pregnancy, from the end of the first trimester to birth.STUDY DESIGN: The cohort consisted of all fetuses scanned in Western Denmark in 2012 and 2013. Anthropometric measures in fetuses with isolated CHDs diagnosed within 12 months after birth were compared with those in the fetuses without CHDs. Z-scores standardized to gestational age were calculated for first trimester biparietal diameter, second trimester head circumference, fetal weight, birthweight, head circumference, and placental weight.RESULTS: We obtained data from 63 349 pregnancies and identified 295 fetuses with isolated CHDs (major n = 145; minor n = 150). The first trimester mean biparietal diameter Z-scores were not different between those with and those without CHDs. The head circumference mean Z-score difference was -0.13 (95% CI, -0.24 to -0.01; P = .03) in the second trimester and -0.22 (95% CI, -0.35 to -0.09; P < .001) at birth. Fetuses with univentricular physiology or tetralogy of Fallot showed the most pronounced compromise in cerebral size.CONCLUSIONS: Our results suggest that the brain alterations inducing an increased risk of impaired neurodevelopment in children with CHDs begin during pregnancy. Although fetuses with univentricular physiology or tetralogy of Fallot exhibited the most pronounced compromise in cerebral size, we recommend neurodevelopmental follow-up for all children with CHDs.
AB - OBJECTIVES: To estimate the association between fetal congenital heart defects (CHDs) and measures of brain size throughout pregnancy, from the end of the first trimester to birth.STUDY DESIGN: The cohort consisted of all fetuses scanned in Western Denmark in 2012 and 2013. Anthropometric measures in fetuses with isolated CHDs diagnosed within 12 months after birth were compared with those in the fetuses without CHDs. Z-scores standardized to gestational age were calculated for first trimester biparietal diameter, second trimester head circumference, fetal weight, birthweight, head circumference, and placental weight.RESULTS: We obtained data from 63 349 pregnancies and identified 295 fetuses with isolated CHDs (major n = 145; minor n = 150). The first trimester mean biparietal diameter Z-scores were not different between those with and those without CHDs. The head circumference mean Z-score difference was -0.13 (95% CI, -0.24 to -0.01; P = .03) in the second trimester and -0.22 (95% CI, -0.35 to -0.09; P < .001) at birth. Fetuses with univentricular physiology or tetralogy of Fallot showed the most pronounced compromise in cerebral size.CONCLUSIONS: Our results suggest that the brain alterations inducing an increased risk of impaired neurodevelopment in children with CHDs begin during pregnancy. Although fetuses with univentricular physiology or tetralogy of Fallot exhibited the most pronounced compromise in cerebral size, we recommend neurodevelopmental follow-up for all children with CHDs.
KW - CHD
KW - congenital heart defects
KW - fetal growth
KW - fetal neurodevelopment
KW - follow-up
KW - head circumference
KW - neurodevelopment
KW - pregnancy
KW - BRAIN-DEVELOPMENT
KW - NEURODEVELOPMENTAL OUTCOMES
KW - NEWBORNS
KW - CHILDREN
KW - NATIONWIDE
KW - DISEASE
KW - GROWTH
KW - BIOMETRY
KW - FETUSES
KW - ASSOCIATION
UR - http://www.scopus.com/inward/record.url?scp=85063813031&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2019.02.042
DO - 10.1016/j.jpeds.2019.02.042
M3 - Journal article
C2 - 30961987
SN - 0022-3476
VL - 210
SP - 146
EP - 153
JO - The Journal of Pediatrics
JF - The Journal of Pediatrics
ER -