Fertility treatment and childhood type 1 diabetes mellitus: a nationwide cohort study of 565,116 live births

Laura Ozer Kettner; Niels Bjerregaard Matthiesen; Cecilia Høst Ramlau-Hansen; Ulrik Schiøler Kesmodel; Bjørn Bay; Tine Brink Henriksen

doi:10.1016/j.fertnstert.2016.09.009

Fertility treatment and childhood type 1 diabetes mellitus: a nationwide cohort study of 565,116 live births

Laura Ozer Kettner, Niels Bjerregaard Matthiesen, Cecilia Høst Ramlau-Hansen, Ulrik Schiøler Kesmodel, Bjørn Bay, Tine Brink Henriksen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

OBJECTIVE: To investigate the association between specific types of fertility treatment and childhood type 1 diabetes mellitus.

DESIGN: Nationwide birth cohort study.

SETTING: Not applicable.

PATIENT(S): All pregnancies resulting in a live-born singleton child in Denmark from 1995 to 2003.

INTERVENTION(S): Not applicable.

MAIN OUTCOME MEASURE(S): Childhood type 1 diabetes mellitus identified from redeemed prescriptions for insulin until 2013.

RESULT(S): The study included 565,116 singleton pregnancies. A total of 14,985 children were conceived by ovulation induction or intrauterine insemination, and 8,490 children were conceived by in vitro fertilization or intracytoplasmic sperm injection. During the follow-up period, 2,011 (0.4%) children developed type 1 diabetes mellitus. The primary analyses showed no association between fertility treatment and childhood type 1 diabetes mellitus. In secondary analyses, ovulation induction or intrauterine insemination with follicle-stimulating hormone was associated with an increased risk of type 1 diabetes mellitus (hazard ratio 3.22; 95% confidence interval 1.20 to 8.64). No clear associations were seen with other types of fertility treatment or with specific treatment indications.

CONCLUSION(S): No association between fertility treatment and childhood type 1 diabetes mellitus was found. Ovulation induction or intrauterine insemination with follicle-stimulating hormone may be associated with an increased risk of childhood type 1 diabetes mellitus. However, this finding may be due to chance or to confounding by indication and thus requires further investigation.

Original language	English
Journal	Fertility and Sterility
Volume	106
Issue	7
Pages (from-to)	1751-1756
Number of pages	6
ISSN	0015-0282
DOIs	https://doi.org/10.1016/j.fertnstert.2016.09.009
Publication status	Published - Dec 2016

Keywords

Assisted reproductive technology
intracytoplasmic sperm injection
intrauterine insemination
in vitro fertilization
ovulation induction
type 1 diabetes mellitus

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10.1016/j.fertnstert.2016.09.009

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@article{3e2177280c7a4310b7178cc5df1fa53c,

title = "Fertility treatment and childhood type 1 diabetes mellitus: a nationwide cohort study of 565,116 live births",

abstract = "OBJECTIVE: To investigate the association between specific types of fertility treatment and childhood type 1 diabetes mellitus.DESIGN: Nationwide birth cohort study.SETTING: Not applicable.PATIENT(S): All pregnancies resulting in a live-born singleton child in Denmark from 1995 to 2003.INTERVENTION(S): Not applicable.MAIN OUTCOME MEASURE(S): Childhood type 1 diabetes mellitus identified from redeemed prescriptions for insulin until 2013.RESULT(S): The study included 565,116 singleton pregnancies. A total of 14,985 children were conceived by ovulation induction or intrauterine insemination, and 8,490 children were conceived by in vitro fertilization or intracytoplasmic sperm injection. During the follow-up period, 2,011 (0.4%) children developed type 1 diabetes mellitus. The primary analyses showed no association between fertility treatment and childhood type 1 diabetes mellitus. In secondary analyses, ovulation induction or intrauterine insemination with follicle-stimulating hormone was associated with an increased risk of type 1 diabetes mellitus (hazard ratio 3.22; 95% confidence interval 1.20 to 8.64). No clear associations were seen with other types of fertility treatment or with specific treatment indications.CONCLUSION(S): No association between fertility treatment and childhood type 1 diabetes mellitus was found. Ovulation induction or intrauterine insemination with follicle-stimulating hormone may be associated with an increased risk of childhood type 1 diabetes mellitus. However, this finding may be due to chance or to confounding by indication and thus requires further investigation.",

keywords = "Assisted reproductive technology, intracytoplasmic sperm injection, intrauterine insemination, in vitro fertilization, ovulation induction, type 1 diabetes mellitus",

author = "Kettner, {Laura Ozer} and Matthiesen, {Niels Bjerregaard} and Ramlau-Hansen, {Cecilia H{\o}st} and Kesmodel, {Ulrik Schi{\o}ler} and Bj{\o}rn Bay and Henriksen, {Tine Brink}",

year = "2016",

month = dec,

doi = "10.1016/j.fertnstert.2016.09.009",

language = "English",

volume = "106",

pages = "1751--1756",

journal = "Fertility and Sterility",

issn = "0015-0282",

publisher = "Elsevier Inc.",

number = "7",

}

Fertility treatment and childhood type 1 diabetes mellitus: a nationwide cohort study of 565,116 live births. / Kettner, Laura Ozer ; Matthiesen, Niels Bjerregaard ; Ramlau-Hansen, Cecilia Høst et al.
In: Fertility and Sterility, Vol. 106, No. 7, 12.2016, p. 1751-1756.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Fertility treatment and childhood type 1 diabetes mellitus

T2 - a nationwide cohort study of 565,116 live births

AU - Kettner, Laura Ozer

AU - Matthiesen, Niels Bjerregaard

AU - Ramlau-Hansen, Cecilia Høst

AU - Kesmodel, Ulrik Schiøler

AU - Bay, Bjørn

AU - Henriksen, Tine Brink

PY - 2016/12

Y1 - 2016/12

N2 - OBJECTIVE: To investigate the association between specific types of fertility treatment and childhood type 1 diabetes mellitus.DESIGN: Nationwide birth cohort study.SETTING: Not applicable.PATIENT(S): All pregnancies resulting in a live-born singleton child in Denmark from 1995 to 2003.INTERVENTION(S): Not applicable.MAIN OUTCOME MEASURE(S): Childhood type 1 diabetes mellitus identified from redeemed prescriptions for insulin until 2013.RESULT(S): The study included 565,116 singleton pregnancies. A total of 14,985 children were conceived by ovulation induction or intrauterine insemination, and 8,490 children were conceived by in vitro fertilization or intracytoplasmic sperm injection. During the follow-up period, 2,011 (0.4%) children developed type 1 diabetes mellitus. The primary analyses showed no association between fertility treatment and childhood type 1 diabetes mellitus. In secondary analyses, ovulation induction or intrauterine insemination with follicle-stimulating hormone was associated with an increased risk of type 1 diabetes mellitus (hazard ratio 3.22; 95% confidence interval 1.20 to 8.64). No clear associations were seen with other types of fertility treatment or with specific treatment indications.CONCLUSION(S): No association between fertility treatment and childhood type 1 diabetes mellitus was found. Ovulation induction or intrauterine insemination with follicle-stimulating hormone may be associated with an increased risk of childhood type 1 diabetes mellitus. However, this finding may be due to chance or to confounding by indication and thus requires further investigation.

AB - OBJECTIVE: To investigate the association between specific types of fertility treatment and childhood type 1 diabetes mellitus.DESIGN: Nationwide birth cohort study.SETTING: Not applicable.PATIENT(S): All pregnancies resulting in a live-born singleton child in Denmark from 1995 to 2003.INTERVENTION(S): Not applicable.MAIN OUTCOME MEASURE(S): Childhood type 1 diabetes mellitus identified from redeemed prescriptions for insulin until 2013.RESULT(S): The study included 565,116 singleton pregnancies. A total of 14,985 children were conceived by ovulation induction or intrauterine insemination, and 8,490 children were conceived by in vitro fertilization or intracytoplasmic sperm injection. During the follow-up period, 2,011 (0.4%) children developed type 1 diabetes mellitus. The primary analyses showed no association between fertility treatment and childhood type 1 diabetes mellitus. In secondary analyses, ovulation induction or intrauterine insemination with follicle-stimulating hormone was associated with an increased risk of type 1 diabetes mellitus (hazard ratio 3.22; 95% confidence interval 1.20 to 8.64). No clear associations were seen with other types of fertility treatment or with specific treatment indications.CONCLUSION(S): No association between fertility treatment and childhood type 1 diabetes mellitus was found. Ovulation induction or intrauterine insemination with follicle-stimulating hormone may be associated with an increased risk of childhood type 1 diabetes mellitus. However, this finding may be due to chance or to confounding by indication and thus requires further investigation.

KW - Assisted reproductive technology

KW - intracytoplasmic sperm injection

KW - intrauterine insemination

KW - in vitro fertilization

KW - ovulation induction

KW - type 1 diabetes mellitus

UR - http://www.scopus.com/inward/record.url?scp=84999025980&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2016.09.009

DO - 10.1016/j.fertnstert.2016.09.009

M3 - Journal article

C2 - 27773424

SN - 0015-0282

VL - 106

SP - 1751

EP - 1756

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 7

ER -

Fertility treatment and childhood type 1 diabetes mellitus: a nationwide cohort study of 565,116 live births

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Keywords

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