Fertilitetsbehandling af mænd med Klinefelters syndrom

Jens Fedder; Anne Skakkebæk; Christan Fuglesang S Jensen; Claus H Gravholt

doi:10.61409/V10240694

Fertilitetsbehandling af mænd med Klinefelters syndrom

Translated title of the contribution: Fertility treatment of men with Klinefelter syndrome

Jens Fedder, Anne Skakkebæk, Christan Fuglesang S Jensen, Claus H Gravholt

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Abstract

In this review is described, that men with Klinefelter syndrome (KS) usually have azoospermia, and only a few have obtained paternity with ejaculated sperm. In Denmark, we performed surgery (micro-TESE or subcapsular orchiectomy) in 93 men with KS and obtained testicular sperm in 42% (39). More than ten children are now born, and several couples still have sperm and embryos cryopreserved with the potential to increase the live birth rate further. Since sperm in men with KS originate from cell lines with a normal chromosome number, children born with a father with KS usually have a normal karyotype and are healthy.

Translated title of the contribution	Fertility treatment of men with Klinefelter syndrome
Original language	Danish
Journal	Ugeskrift for Læger
Volume	187
Issue	12
ISSN	0041-5782
DOIs	https://doi.org/10.61409/V10240694
Publication status	Published - 17 Mar 2025

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title = "Fertilitetsbehandling af m{\ae}nd med Klinefelters syndrom",

abstract = "In this review is described, that men with Klinefelter syndrome (KS) usually have azoospermia, and only a few have obtained paternity with ejaculated sperm. In Denmark, we performed surgery (micro-TESE or subcapsular orchiectomy) in 93 men with KS and obtained testicular sperm in 42\% (39). More than ten children are now born, and several couples still have sperm and embryos cryopreserved with the potential to increase the live birth rate further. Since sperm in men with KS originate from cell lines with a normal chromosome number, children born with a father with KS usually have a normal karyotype and are healthy.",

keywords = "Humans, Klinefelter Syndrome/complications, Male, Azoospermia/therapy, Infertility, Male/etiology, Sperm Retrieval, Orchiectomy, Pregnancy, Cryopreservation, Female, Reproductive Techniques, Assisted",

author = "Jens Fedder and Anne Skakkeb{\ae}k and Jensen, \{Christan Fuglesang S\} and Gravholt, \{Claus H\}",

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T1 - Fertilitetsbehandling af mænd med Klinefelters syndrom

AU - Fedder, Jens

AU - Skakkebæk, Anne

AU - Jensen, Christan Fuglesang S

AU - Gravholt, Claus H

N1 - Published under Open Access CC-BY-NC-BD 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/.

PY - 2025/3/17

Y1 - 2025/3/17

N2 - In this review is described, that men with Klinefelter syndrome (KS) usually have azoospermia, and only a few have obtained paternity with ejaculated sperm. In Denmark, we performed surgery (micro-TESE or subcapsular orchiectomy) in 93 men with KS and obtained testicular sperm in 42% (39). More than ten children are now born, and several couples still have sperm and embryos cryopreserved with the potential to increase the live birth rate further. Since sperm in men with KS originate from cell lines with a normal chromosome number, children born with a father with KS usually have a normal karyotype and are healthy.

AB - In this review is described, that men with Klinefelter syndrome (KS) usually have azoospermia, and only a few have obtained paternity with ejaculated sperm. In Denmark, we performed surgery (micro-TESE or subcapsular orchiectomy) in 93 men with KS and obtained testicular sperm in 42% (39). More than ten children are now born, and several couples still have sperm and embryos cryopreserved with the potential to increase the live birth rate further. Since sperm in men with KS originate from cell lines with a normal chromosome number, children born with a father with KS usually have a normal karyotype and are healthy.

KW - Humans

KW - Klinefelter Syndrome/complications

KW - Male

KW - Azoospermia/therapy

KW - Infertility, Male/etiology

KW - Sperm Retrieval

KW - Orchiectomy

KW - Pregnancy

KW - Cryopreservation

KW - Female

KW - Reproductive Techniques, Assisted

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U2 - 10.61409/V10240694

DO - 10.61409/V10240694

M3 - Review

C2 - 40152162

SN - 0041-5782

VL - 187

JO - Ugeskrift for Læger

JF - Ugeskrift for Læger

IS - 12

ER -

Fertilitetsbehandling af mænd med Klinefelters syndrom

Abstract

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