Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study)

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • Sine Knorr
  • Birgitte Bytoft, Department of Obstetrics, Copenhagen University Hospital Rigshospitalet, Copenhagen.
  • ,
  • Zuzana Lohse, Steno Diabetes Center Odense, Odense University Hospital
  • ,
  • Anne B Boisen
  • ,
  • Tine D Clausen, Department of Gynecology and Obstetrics, Nordsjaellands Hospital, Hilleroed, Denmark.
  • ,
  • Rikke B Jensen, Department of Growth and Reproduction, Rigshospitalet , University of Copenhagen , Copenhagen , Denmark.
  • ,
  • Peter Damm, Institute of Clinical Medicines, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Department of Obstetrics and Gynecology, Odense University Hospital, Odense, Denmark
  • ,
  • Henning Beck-Nielsen, Steno Diabetes Center Odense, Odense University Hospital
  • ,
  • Jens J Holst, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen
  • ,
  • Bolette Hartmann, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen
  • ,
  • Holger J Møller
  • Kurt Højlund, Steno Diabetes Center Odense, Odense University Hospital
  • ,
  • Claus H Gravholt
  • Dorte M Jensen, Steno Diabetes Center Odense, Odense University Hospital, Department of Obstetrics and Gynecology, Odense University Hospital, Odense, Denmark

OBJECTIVE: Intrauterine exposure to maternal type 1 diabetes is associated with a less favorable metabolic profile later in life. Nonalcoholic fatty liver disease is the hepatic manifestation of a cluster of metabolic abnormalities linked to insulin resistance. This study aimed to evaluate the effect of maternal pregestational type 1 diabetes on the presence of fatty liver in offspring and the association between maternal BMI, glycemic control during pregnancy, offspring metabolic risk factors, and offspring level of soluble CD163 (sCD163; a marker of macrophage activation) and risk of fatty liver.

RESEARCH DESIGN AND METHODS: This study was a prospective nationwide follow-up study of offspring (n = 278) of mothers with pregestational type 1 diabetes between 1993 and 1999 and matched control subjects (n = 303). Mean age at the time of follow-up was 16.7 years (range 13.0-20.4 years). We used the fatty liver index (FLI) and waist-to-height ratio (WHtR) to evaluate the presence of fatty liver among the offspring. An FLI ≥60 or WHtR >0.469 were used as cutoff points for fatty liver.

RESULTS: More type 1 diabetes-exposed offspring had high FLI and WHtR indices compared with unexposed control subjects. We found significant associations between increasing maternal prepregnancy BMI, being born large for gestational age, offspring level of sCD163, as well as offspring metabolic risk factors (decreasing adiponectin and HDL cholesterol and increasing leptin, HOMA of insulin resistance, and HOMA of insulin secretion) and degree of fatty liver.

CONCLUSIONS: Intrauterine exposure to maternal type 1 diabetes and higher maternal prepregnancy BMI may predispose to fatty liver in the offspring. Offspring metabolic risk factors, including sCD163 levels, are associated with indices of fatty liver.

Original languageEnglish
JournalDiabetes Care
Volume42
Issue8
Pages (from-to)1560-1568
Number of pages9
ISSN0149-5992
DOIs
Publication statusPublished - Aug 2019

See relations at Aarhus University Citationformats

ID: 156001369