Family aggregation of mental disorders in the nationwide Danish three generation study

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Family aggregation of mental disorders in the nationwide Danish three generation study. / Steinhausen, Hans-Christoph; Foldager, Leslie; Perto, Gurli; Munk-Jørgensen, Povl.

In: European Archives of Psychiatry and Clinical Neuroscience, Vol. 259, No. 5, 2009, p. 270-277.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Steinhausen, H-C, Foldager, L, Perto, G & Munk-Jørgensen, P 2009, 'Family aggregation of mental disorders in the nationwide Danish three generation study', European Archives of Psychiatry and Clinical Neuroscience, vol. 259, no. 5, pp. 270-277. https://doi.org/10.1007/s00406-008-0865-0

APA

Steinhausen, H-C., Foldager, L., Perto, G., & Munk-Jørgensen, P. (2009). Family aggregation of mental disorders in the nationwide Danish three generation study. European Archives of Psychiatry and Clinical Neuroscience, 259(5), 270-277. https://doi.org/10.1007/s00406-008-0865-0

CBE

Steinhausen H-C, Foldager L, Perto G, Munk-Jørgensen P. 2009. Family aggregation of mental disorders in the nationwide Danish three generation study. European Archives of Psychiatry and Clinical Neuroscience. 259(5):270-277. https://doi.org/10.1007/s00406-008-0865-0

MLA

Steinhausen, Hans-Christoph et al. "Family aggregation of mental disorders in the nationwide Danish three generation study". European Archives of Psychiatry and Clinical Neuroscience. 2009, 259(5). 270-277. https://doi.org/10.1007/s00406-008-0865-0

Vancouver

Steinhausen H-C, Foldager L, Perto G, Munk-Jørgensen P. Family aggregation of mental disorders in the nationwide Danish three generation study. European Archives of Psychiatry and Clinical Neuroscience. 2009;259(5):270-277. https://doi.org/10.1007/s00406-008-0865-0

Author

Steinhausen, Hans-Christoph ; Foldager, Leslie ; Perto, Gurli ; Munk-Jørgensen, Povl. / Family aggregation of mental disorders in the nationwide Danish three generation study. In: European Archives of Psychiatry and Clinical Neuroscience. 2009 ; Vol. 259, No. 5. pp. 270-277.

Bibtex

@article{9c4270a0184a11de8317000ea68e967b,
title = "Family aggregation of mental disorders in the nationwide Danish three generation study",
abstract = "OBJECTIVE: The study of familial aggregation of major mental disorders in a national population. METHOD: Within a Danish register-based cohort study, aggregation of mental disorders was analysed in all case-probands with first psychiatric contact before the age of 19 years in the time period between 1 April 1969 and 29 June 2004 followed up until the age of 35 years, their first-degree relatives, and a matched group of control-probands including their first-degree relatives. RESULTS: Hazard rate ratios were significantly elevated for cases as compared to controls for all diagnoses among probands, parents, and siblings. Among children of the probands, these ratios were significantly elevated for neurotic (anxiety) disorders, mental retardation, developmental disorders, behavioural and emotional disorders of childhood and adolescence, and miscellaneous disorders. Family aggregation of any diagnosis was significantly higher in probands with substance use disorder, schizophrenia, affective disorders, neurotic (anxiety) disorders, and miscellaneous disorders. There was specificity of familial transmission for affective and neurotic (anxiety) disorders. CONCLUSION: This large nationwide study found some differential patterns of familial aggregation of major mental disorders.",
author = "Hans-Christoph Steinhausen and Leslie Foldager and Gurli Perto and Povl Munk-J{\o}rgensen",
year = "2009",
doi = "10.1007/s00406-008-0865-0",
language = "English",
volume = "259",
pages = "270--277",
journal = "European Archives of Psychiatry and Clinical Neuroscience",
issn = "0940-1334",
publisher = "Springer Medizin",
number = "5",

}

RIS

TY - JOUR

T1 - Family aggregation of mental disorders in the nationwide Danish three generation study

AU - Steinhausen, Hans-Christoph

AU - Foldager, Leslie

AU - Perto, Gurli

AU - Munk-Jørgensen, Povl

PY - 2009

Y1 - 2009

N2 - OBJECTIVE: The study of familial aggregation of major mental disorders in a national population. METHOD: Within a Danish register-based cohort study, aggregation of mental disorders was analysed in all case-probands with first psychiatric contact before the age of 19 years in the time period between 1 April 1969 and 29 June 2004 followed up until the age of 35 years, their first-degree relatives, and a matched group of control-probands including their first-degree relatives. RESULTS: Hazard rate ratios were significantly elevated for cases as compared to controls for all diagnoses among probands, parents, and siblings. Among children of the probands, these ratios were significantly elevated for neurotic (anxiety) disorders, mental retardation, developmental disorders, behavioural and emotional disorders of childhood and adolescence, and miscellaneous disorders. Family aggregation of any diagnosis was significantly higher in probands with substance use disorder, schizophrenia, affective disorders, neurotic (anxiety) disorders, and miscellaneous disorders. There was specificity of familial transmission for affective and neurotic (anxiety) disorders. CONCLUSION: This large nationwide study found some differential patterns of familial aggregation of major mental disorders.

AB - OBJECTIVE: The study of familial aggregation of major mental disorders in a national population. METHOD: Within a Danish register-based cohort study, aggregation of mental disorders was analysed in all case-probands with first psychiatric contact before the age of 19 years in the time period between 1 April 1969 and 29 June 2004 followed up until the age of 35 years, their first-degree relatives, and a matched group of control-probands including their first-degree relatives. RESULTS: Hazard rate ratios were significantly elevated for cases as compared to controls for all diagnoses among probands, parents, and siblings. Among children of the probands, these ratios were significantly elevated for neurotic (anxiety) disorders, mental retardation, developmental disorders, behavioural and emotional disorders of childhood and adolescence, and miscellaneous disorders. Family aggregation of any diagnosis was significantly higher in probands with substance use disorder, schizophrenia, affective disorders, neurotic (anxiety) disorders, and miscellaneous disorders. There was specificity of familial transmission for affective and neurotic (anxiety) disorders. CONCLUSION: This large nationwide study found some differential patterns of familial aggregation of major mental disorders.

U2 - 10.1007/s00406-008-0865-0

DO - 10.1007/s00406-008-0865-0

M3 - Journal article

C2 - 19224110

VL - 259

SP - 270

EP - 277

JO - European Archives of Psychiatry and Clinical Neuroscience

JF - European Archives of Psychiatry and Clinical Neuroscience

SN - 0940-1334

IS - 5

ER -