Department of Economics and Business Economics

Familial Liability to Epilepsy and Attention-Deficit/Hyperactivity Disorder: A Nationwide Cohort Study

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Familial Liability to Epilepsy and Attention-Deficit/Hyperactivity Disorder : A Nationwide Cohort Study. / Brikell, Isabell; Ghirardi, Laura; D'Onofrio, Brian M; Dunn, David W; Almqvist, Catarina; Dalsgaard, Søren; Kuja-Halkola, Ralf; Larsson, Henrik.

In: Biological Psychiatry, Vol. 83, No. 2, 15.01.2018, p. 173-180.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Brikell, I, Ghirardi, L, D'Onofrio, BM, Dunn, DW, Almqvist, C, Dalsgaard, S, Kuja-Halkola, R & Larsson, H 2018, 'Familial Liability to Epilepsy and Attention-Deficit/Hyperactivity Disorder: A Nationwide Cohort Study', Biological Psychiatry, vol. 83, no. 2, pp. 173-180. https://doi.org/10.1016/j.biopsych.2017.08.006

APA

Brikell, I., Ghirardi, L., D'Onofrio, B. M., Dunn, D. W., Almqvist, C., Dalsgaard, S., ... Larsson, H. (2018). Familial Liability to Epilepsy and Attention-Deficit/Hyperactivity Disorder: A Nationwide Cohort Study. Biological Psychiatry, 83(2), 173-180. https://doi.org/10.1016/j.biopsych.2017.08.006

CBE

Brikell I, Ghirardi L, D'Onofrio BM, Dunn DW, Almqvist C, Dalsgaard S, Kuja-Halkola R, Larsson H. 2018. Familial Liability to Epilepsy and Attention-Deficit/Hyperactivity Disorder: A Nationwide Cohort Study. Biological Psychiatry. 83(2):173-180. https://doi.org/10.1016/j.biopsych.2017.08.006

MLA

Vancouver

Brikell I, Ghirardi L, D'Onofrio BM, Dunn DW, Almqvist C, Dalsgaard S et al. Familial Liability to Epilepsy and Attention-Deficit/Hyperactivity Disorder: A Nationwide Cohort Study. Biological Psychiatry. 2018 Jan 15;83(2):173-180. https://doi.org/10.1016/j.biopsych.2017.08.006

Author

Brikell, Isabell ; Ghirardi, Laura ; D'Onofrio, Brian M ; Dunn, David W ; Almqvist, Catarina ; Dalsgaard, Søren ; Kuja-Halkola, Ralf ; Larsson, Henrik. / Familial Liability to Epilepsy and Attention-Deficit/Hyperactivity Disorder : A Nationwide Cohort Study. In: Biological Psychiatry. 2018 ; Vol. 83, No. 2. pp. 173-180.

Bibtex

@article{068814d09083431397e142762b778f8d,
title = "Familial Liability to Epilepsy and Attention-Deficit/Hyperactivity Disorder: A Nationwide Cohort Study",
abstract = "BACKGROUND: Epilepsy and attention-deficit/hyperactivity disorder (ADHD) are strongly associated; however, the underlying factors contributing to their co-occurrence remain unclear. A shared genetic liability has been proposed as one possible mechanism. Therefore, our goal in this study was to investigate the familial coaggregation of epilepsy and ADHD and to estimate the contribution of genetic and environmental risk factors to their co-occurrence.METHODS: We identified 1,899,654 individuals born between 1987 and 2006 via national Swedish registers and linked each individual to his or her biological relatives. We used logistic regression to estimate the association between epilepsy and ADHD within individual and across relatives. Quantitative genetic modeling was used to decompose the cross-disorder covariance into genetic and environmental factors.RESULTS: Individuals with epilepsy had a statistically significant increased risk of ADHD (odds ratio [OR] = 3.47, 95{\%} confidence interval [CI] = 3.33-3.62). This risk increase extended to children whose mothers had epilepsy (OR = 1.85, 95{\%} CI = 1.75-1.96), children whose fathers had epilepsy (OR = 1.64, 95{\%} CI = 1.54-1.74), full siblings (OR = 1.56, 95{\%} CI = 1.46-1.67), maternal half siblings (OR = 1.28, 95{\%} CI = 1.14-1.43), paternal half siblings (OR = 1.10, 95{\%} CI = 0.96-1.25), and cousins (OR = 1.15, 95{\%} CI = 1.10-1.20). The genetic correlation was 0.21 (95{\%} CI = 0.02-0.40) and explained 40{\%} of the phenotypic correlation between epilepsy and ADHD, with the remaining variance largely explained by nonshared environmental factors (49{\%}, nonshared environmental correlation = 0.36, 95{\%} CI = 0.23-0.49). The contribution of shared environmental factors to the cross-disorder overlap was not statistically significant (11{\%}, shared environmental correlation = 0.32, 95{\%} CI = -0.16-0.79).CONCLUSIONS: This study demonstrates a strong and etiologically complex association between epilepsy and ADHD, with shared familial factors and risk factors unique to the individual contributing to co-occurrence of the disorders. Our findings suggest that epilepsy and ADHD may share less genetic risk as compared with other neurodevelopmental disorders.",
keywords = "Journal Article",
author = "Isabell Brikell and Laura Ghirardi and D'Onofrio, {Brian M} and Dunn, {David W} and Catarina Almqvist and S{\o}ren Dalsgaard and Ralf Kuja-Halkola and Henrik Larsson",
note = "Copyright {\circledC} 2017 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.",
year = "2018",
month = "1",
day = "15",
doi = "10.1016/j.biopsych.2017.08.006",
language = "English",
volume = "83",
pages = "173--180",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Familial Liability to Epilepsy and Attention-Deficit/Hyperactivity Disorder

T2 - A Nationwide Cohort Study

AU - Brikell, Isabell

AU - Ghirardi, Laura

AU - D'Onofrio, Brian M

AU - Dunn, David W

AU - Almqvist, Catarina

AU - Dalsgaard, Søren

AU - Kuja-Halkola, Ralf

AU - Larsson, Henrik

N1 - Copyright © 2017 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

PY - 2018/1/15

Y1 - 2018/1/15

N2 - BACKGROUND: Epilepsy and attention-deficit/hyperactivity disorder (ADHD) are strongly associated; however, the underlying factors contributing to their co-occurrence remain unclear. A shared genetic liability has been proposed as one possible mechanism. Therefore, our goal in this study was to investigate the familial coaggregation of epilepsy and ADHD and to estimate the contribution of genetic and environmental risk factors to their co-occurrence.METHODS: We identified 1,899,654 individuals born between 1987 and 2006 via national Swedish registers and linked each individual to his or her biological relatives. We used logistic regression to estimate the association between epilepsy and ADHD within individual and across relatives. Quantitative genetic modeling was used to decompose the cross-disorder covariance into genetic and environmental factors.RESULTS: Individuals with epilepsy had a statistically significant increased risk of ADHD (odds ratio [OR] = 3.47, 95% confidence interval [CI] = 3.33-3.62). This risk increase extended to children whose mothers had epilepsy (OR = 1.85, 95% CI = 1.75-1.96), children whose fathers had epilepsy (OR = 1.64, 95% CI = 1.54-1.74), full siblings (OR = 1.56, 95% CI = 1.46-1.67), maternal half siblings (OR = 1.28, 95% CI = 1.14-1.43), paternal half siblings (OR = 1.10, 95% CI = 0.96-1.25), and cousins (OR = 1.15, 95% CI = 1.10-1.20). The genetic correlation was 0.21 (95% CI = 0.02-0.40) and explained 40% of the phenotypic correlation between epilepsy and ADHD, with the remaining variance largely explained by nonshared environmental factors (49%, nonshared environmental correlation = 0.36, 95% CI = 0.23-0.49). The contribution of shared environmental factors to the cross-disorder overlap was not statistically significant (11%, shared environmental correlation = 0.32, 95% CI = -0.16-0.79).CONCLUSIONS: This study demonstrates a strong and etiologically complex association between epilepsy and ADHD, with shared familial factors and risk factors unique to the individual contributing to co-occurrence of the disorders. Our findings suggest that epilepsy and ADHD may share less genetic risk as compared with other neurodevelopmental disorders.

AB - BACKGROUND: Epilepsy and attention-deficit/hyperactivity disorder (ADHD) are strongly associated; however, the underlying factors contributing to their co-occurrence remain unclear. A shared genetic liability has been proposed as one possible mechanism. Therefore, our goal in this study was to investigate the familial coaggregation of epilepsy and ADHD and to estimate the contribution of genetic and environmental risk factors to their co-occurrence.METHODS: We identified 1,899,654 individuals born between 1987 and 2006 via national Swedish registers and linked each individual to his or her biological relatives. We used logistic regression to estimate the association between epilepsy and ADHD within individual and across relatives. Quantitative genetic modeling was used to decompose the cross-disorder covariance into genetic and environmental factors.RESULTS: Individuals with epilepsy had a statistically significant increased risk of ADHD (odds ratio [OR] = 3.47, 95% confidence interval [CI] = 3.33-3.62). This risk increase extended to children whose mothers had epilepsy (OR = 1.85, 95% CI = 1.75-1.96), children whose fathers had epilepsy (OR = 1.64, 95% CI = 1.54-1.74), full siblings (OR = 1.56, 95% CI = 1.46-1.67), maternal half siblings (OR = 1.28, 95% CI = 1.14-1.43), paternal half siblings (OR = 1.10, 95% CI = 0.96-1.25), and cousins (OR = 1.15, 95% CI = 1.10-1.20). The genetic correlation was 0.21 (95% CI = 0.02-0.40) and explained 40% of the phenotypic correlation between epilepsy and ADHD, with the remaining variance largely explained by nonshared environmental factors (49%, nonshared environmental correlation = 0.36, 95% CI = 0.23-0.49). The contribution of shared environmental factors to the cross-disorder overlap was not statistically significant (11%, shared environmental correlation = 0.32, 95% CI = -0.16-0.79).CONCLUSIONS: This study demonstrates a strong and etiologically complex association between epilepsy and ADHD, with shared familial factors and risk factors unique to the individual contributing to co-occurrence of the disorders. Our findings suggest that epilepsy and ADHD may share less genetic risk as compared with other neurodevelopmental disorders.

KW - Journal Article

U2 - 10.1016/j.biopsych.2017.08.006

DO - 10.1016/j.biopsych.2017.08.006

M3 - Journal article

C2 - 28950988

VL - 83

SP - 173

EP - 180

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 2

ER -