Aarhus University Seal / Aarhus Universitets segl

Extracellular 2'-5' oligoadenylate synthetase stimulates RNase L-independent antiviral activity: a novel mechanism of virus-induced innate immunity

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

The 2'-5' oligoadenylate synthetase (OAS) proteins are traditionally considered intracellular antiviral proteins. However, several studies demonstrate a correlation between the concentration of freely circulating OAS protein in sera from hepatitis C patients and their clinical prognosis. Here we demonstrate that extracellular OAS1 enters into cells and possesses a strong antiviral activity, both in vitro and in vivo, which is independent of RNase L. The OAS protein directly inhibits viral proliferation and does not require the activation of known antiviral signaling pathways. We propose that OAS produced by cells infected with viruses is released to the extracellular space, where it acts as a paracrine antiviral agent. Thus, the OAS protein represents the first direct antiviral compound released by virus-infected cells.
Original languageEnglish
JournalJournal of Virology
Volume84
Issue22
Pages (from-to)11898-904
Number of pages7
ISSN0022-538X
DOIs
Publication statusPublished - 1 Nov 2010

    Research areas

  • 2',5'-Oligoadenylate Synthetase, Animals, Antiviral Agents, Cell Line, Endoribonucleases, Extracellular Space, Host-Pathogen Interactions, Humans, Immunity, Innate, Mice, Mice, Inbred C57BL, Virus Diseases, Virus Physiological Phenomena, Viruses

See relations at Aarhus University Citationformats

ID: 34362789