Extended scaffold glucuronides: en route to the universal synthesis of O-aryl glucuronide prodrugs

Raoul Walther; Morten T. Jarlstad Olesen; Alexander N. Zelikin

doi:10.1039/c9ob01384a

Extended scaffold glucuronides: en route to the universal synthesis of O-aryl glucuronide prodrugs

Raoul Walther
, Morten T. Jarlstad Olesen
, Alexander N. Zelikin^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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Abstract

We demonstrate that an extended scaffold based on a self-immolative linker (SIL) enables the universal production of O-aryl glucuronide prodrugs: high yield glucuronidation is performed on a precursor substrate (SIL) and the subsequent drug conjugation proceeds via less challenging chemical reactions.

Original language	English
Journal	Organic & Biomolecular Chemistry
Volume	17
Issue	29
Pages (from-to)	6970-6974
Number of pages	5
ISSN	1477-0520
DOIs	https://doi.org/10.1039/c9ob01384a
Publication status	Published - Aug 2019

Keywords

GLYCOSIDES
THERAPIES
CHEMISTRY
DELIVERY
SYSTEM

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10.1039/c9ob01384a

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title = "Extended scaffold glucuronides: en route to the universal synthesis of O-aryl glucuronide prodrugs",

abstract = "We demonstrate that an extended scaffold based on a self-immolative linker (SIL) enables the universal production of O-aryl glucuronide prodrugs: high yield glucuronidation is performed on a precursor substrate (SIL) and the subsequent drug conjugation proceeds via less challenging chemical reactions.",

keywords = "GLYCOSIDES, THERAPIES, CHEMISTRY, DELIVERY, SYSTEM",

author = "Raoul Walther and Olesen, \{Morten T. Jarlstad\} and Zelikin, \{Alexander N.\}",

year = "2019",

month = aug,

doi = "10.1039/c9ob01384a",

language = "English",

volume = "17",

pages = "6970--6974",

journal = "Organic \& Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "29",

}

Extended scaffold glucuronides: en route to the universal synthesis of O-aryl glucuronide prodrugs. / Walther, Raoul; Olesen, Morten T. Jarlstad ; Zelikin, Alexander N.
In: Organic & Biomolecular Chemistry, Vol. 17, No. 29, 08.2019, p. 6970-6974.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Extended scaffold glucuronides

T2 - en route to the universal synthesis of O-aryl glucuronide prodrugs

AU - Walther, Raoul

AU - Olesen, Morten T. Jarlstad

AU - Zelikin, Alexander N.

PY - 2019/8

Y1 - 2019/8

N2 - We demonstrate that an extended scaffold based on a self-immolative linker (SIL) enables the universal production of O-aryl glucuronide prodrugs: high yield glucuronidation is performed on a precursor substrate (SIL) and the subsequent drug conjugation proceeds via less challenging chemical reactions.

AB - We demonstrate that an extended scaffold based on a self-immolative linker (SIL) enables the universal production of O-aryl glucuronide prodrugs: high yield glucuronidation is performed on a precursor substrate (SIL) and the subsequent drug conjugation proceeds via less challenging chemical reactions.

KW - GLYCOSIDES

KW - THERAPIES

KW - CHEMISTRY

KW - DELIVERY

KW - SYSTEM

U2 - 10.1039/c9ob01384a

DO - 10.1039/c9ob01384a

M3 - Journal article

C2 - 31290904

SN - 1477-0520

VL - 17

SP - 6970

EP - 6974

JO - Organic & Biomolecular Chemistry

JF - Organic & Biomolecular Chemistry

IS - 29

ER -

Extended scaffold glucuronides: en route to the universal synthesis of O-aryl glucuronide prodrugs

Abstract

Keywords

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