Extended scaffold glucuronides: en route to the universal synthesis of O-aryl glucuronide prodrugs

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DOI

We demonstrate that an extended scaffold based on a self-immolative linker (SIL) enables the universal production of O-aryl glucuronide prodrugs: high yield glucuronidation is performed on a precursor substrate (SIL) and the subsequent drug conjugation proceeds via less challenging chemical reactions.

Original languageEnglish
JournalOrganic & Biomolecular Chemistry
Volume17
Issue29
Pages (from-to)6970-6974
Number of pages5
ISSN1477-0520
DOIs
Publication statusPublished - Aug 2019

    Research areas

  • GLYCOSIDES, THERAPIES, CHEMISTRY, DELIVERY, SYSTEM

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