Research
Exposure to surrounding greenness and natural-cause and cause-specific mortality in the ELAPSE pooled cohort
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review
DOI
- https://doi.org/10.1016/j.envint.2022.107341
Final published version
- Ainhoa Bereziartua, Utrecht University ,
- Jie Chen, Utrecht University ,
- Kees de Hoogh, Swiss Tropical and Public Health Institute, University of Basel ,
- Sophia Rodopoulou, University of Athens ,
- Zorana J. Andersen, University of Copenhagen ,
- Tom Bellander, Karolinska Institutet, Centre for Occupational and Environmental Medicine ,
- Jørgen Brandt
- Daniela Fecht, Imperial College London ,
- Francesco Forastiere, Department of Epidemiology Lazio Regional Health Service, Imperial College London ,
- John Gulliver, Imperial College London, University of Leicester ,
- Ole Hertel
- Barbara Hoffmann, Heinrich Heine University Düsseldorf ,
- Ulla Arthur Hvidtfeldt, Danish Cancer Society ,
- W. M.Monique Verschuren, Utrecht University ,
- Karl Heinz Jöckel, University of Duisburg-Essen ,
- Jeanette T. Jørgensen, University of Copenhagen ,
- Klea Katsouyanni, University of Athens, Imperial College London ,
- Matthias Ketzel
- Norun Hjertager Krog, Norwegian Institute of Public Health ,
- Boel Brynedal, Karolinska Institutet ,
- Karin Leander, Karolinska Institutet ,
- Shuo Liu, University of Copenhagen ,
- Petter Ljungman, Karolinska Institutet ,
- Elodie Faure, Universite Paris-Saclay ,
- Patrik K.E. Magnusson, Karolinska Institutet ,
- Gabriele Nagel, Ulm University ,
- Göran Pershagen, Karolinska Institutet, Centre for Occupational and Environmental Medicine ,
- Annette Peters, Helmholtz Zentrum München - German Research Center for Environmental Health, Ludwig Maximilian University of Munich ,
- Ole Raaschou-Nielsen
- Matteo Renzi, Department of Epidemiology Lazio Regional Health Service ,
- Debora Rizzuto, Karolinska Institutet, The Stockholm Gerontology Research Center ,
- Evangelia Samoli, University of Athens ,
- Yvonne T. van der Schouw, Utrecht University ,
- Sara Schramm, University of Duisburg-Essen ,
- Gianluca Severi, Universite Paris-Saclay, University of Florence ,
- Massimo Stafoggia, Karolinska Institutet, Department of Epidemiology Lazio Regional Health Service ,
- Maciej Strak, Utrecht University, National Institute for Public Health and the Environment (RIVM) ,
- Mette Sørensen, Danish Cancer Society, Roskilde University ,
- Anne Tjønneland, Danish Cancer Society, Genes and Environment (DGE) ,
- Gudrun Weinmayr, Ulm University ,
- Kathrin Wolf, Helmholtz Zentrum München - German Research Center for Environmental Health ,
- Emanuel Zitt, LKH Feldkirch, Agency for Preventive and Social Medicine, Bregenz, Austria. ,
- Bert Brunekreef, Utrecht University ,
- Gerard Hoek, Utrecht University
Background: The majority of studies have shown higher greenness exposure associated with reduced mortality risks, but few controlled for spatially correlated air pollution and traffic noise exposures. We aim to address this research gap in the ELAPSE pooled cohort. Methods: Mean Normalized Difference Vegetation Index (NDVI) in a 300-m grid cell and 1-km radius were assigned to participants’ baseline home addresses as a measure of surrounding greenness exposure. We used Cox proportional hazards models to estimate the association of NDVI exposure with natural-cause and cause-specific mortality, adjusting for a number of potential confounders including socioeconomic status and lifestyle factors at individual and area-levels. We further assessed the associations between greenness exposure and mortality after adjusting for fine particulate matter (PM2.5), nitrogen dioxide (NO2) and road traffic noise. Results: The pooled study population comprised 327,388 individuals who experienced 47,179 natural-cause deaths during 6,374,370 person-years of follow-up. The mean NDVI in the pooled cohort was 0.33 (SD 0.1) and 0.34 (SD 0.1) in the 300-m grid and 1-km buffer. In the main fully adjusted model, 0.1 unit increment of NDVI inside 300-m grid was associated with 5% lower risk of natural-cause mortality (Hazard Ratio (HR) 0.95 (95% CI: 0.94, 0.96)). The associations attenuated after adjustment for air pollution [HR (95% CI): 0.97 (0.96, 0.98) adjusted for PM2.5; 0.98 (0.96, 0.99) adjusted for NO2]. Additional adjustment for traffic noise hardly affected the associations. Consistent results were observed for NDVI within 1-km buffer. After adjustment for air pollution, NDVI was inversely associated with diabetes, respiratory and lung cancer mortality, yet with wider 95% confidence intervals. No association with cardiovascular mortality was found. Conclusions: We found a significant inverse association between surrounding greenness and natural-cause mortality, which remained after adjusting for spatially correlated air pollution and traffic noise.
| Original language | English |
|---|---|
| Article number | 107341 |
| Journal | Environment International |
| Volume | 166 |
| Number of pages | 13 |
| ISSN | 0160-4120 |
| DOIs | |
| Publication status | Published - Aug 2022 |
Bibliographical note
Publisher Copyright:
© 2022 The Authors
- Air Pollution, Green space, Mortality, Traffic Noise
Research areas
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ID: 281890699