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Exposure to neuroactive non-organochlorine insecticides, and diabetes mellitus and related metabolic disturbances: Protocol for a systematic review and meta-analysis

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Exposure to neuroactive non-organochlorine insecticides, and diabetes mellitus and related metabolic disturbances: Protocol for a systematic review and meta-analysis. / Hansen, Martin Rune Hassan; Jørs, Erik; Sandbæk, Annelli; Kolstad, Henrik A.; Schullehner, Jörg; Schlünssen, Vivi.

In: Environment International, Vol. 127, 06.2019, p. 664-670.

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@article{9cab6a6fee164d0698c3bbb9f86584bf,
title = "Exposure to neuroactive non-organochlorine insecticides, and diabetes mellitus and related metabolic disturbances: Protocol for a systematic review and meta-analysis",
abstract = "OBJECTIVES:To assess whether exposure to specific classes of neuroactive non-organochlorine insecticides is associated with diabetes mellitus or related metabolic traits.METHODS:Eligibility criteria: Any type of epidemiological and human exposure studies providing an exposure contrast to neuroactive non-organochlorine insecticides and a measure of association to diabetes mellitus or related metabolic traits. We will include published peer-reviewed studies in both English and non-English language.INFORMATION SOURCES:Articles will be located in the NCBI PubMed, Embase, Scopus, Web of Science and LILACS databases, supplemented with manual searching of reference lists and articles citing the included studies. Risk of bias assessment: Risk of bias in individual studies will be assessed using tools from the Navigation Guide systematic review methodology, while the risk of bias at the outcome level will be assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) guidelines. Data synthesis and analysis: When studies are sufficiently similar in population, exposure, comparator and effect estimate to meaningfully allow quantitative synthesis, we will perform meta-analysis. Otherwise, results will be summarized qualitatively.FUNDING:The authors are paid employees of their respective institutions. MRHH is a Ph.D. student working under grants from Aarhus University and the National Research Centre for the Working Environment.REGISTRATION:PROSPERO CRD42017068861.",
keywords = "pesticid, insekticid, spr{\o}jtegift, insektmiddel, plantebeskyttelsesmiddel, diabetes, sukkersyge, diabetes mellitus, blood glucose, Hyperglycaemia, pesticide, insecticide",
author = "Hansen, {Martin Rune Hassan} and Erik J{\o}rs and Annelli Sandb{\ae}k and Kolstad, {Henrik A.} and J{\"o}rg Schullehner and Vivi Schl{\"u}nssen",
year = "2019",
month = jun,
doi = "10.1016/j.envint.2019.02.074",
language = "English",
volume = "127",
pages = "664--670",
journal = "Environment International",
issn = "0160-4120",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Exposure to neuroactive non-organochlorine insecticides, and diabetes mellitus and related metabolic disturbances: Protocol for a systematic review and meta-analysis

AU - Hansen, Martin Rune Hassan

AU - Jørs, Erik

AU - Sandbæk, Annelli

AU - Kolstad, Henrik A.

AU - Schullehner, Jörg

AU - Schlünssen, Vivi

PY - 2019/6

Y1 - 2019/6

N2 - OBJECTIVES:To assess whether exposure to specific classes of neuroactive non-organochlorine insecticides is associated with diabetes mellitus or related metabolic traits.METHODS:Eligibility criteria: Any type of epidemiological and human exposure studies providing an exposure contrast to neuroactive non-organochlorine insecticides and a measure of association to diabetes mellitus or related metabolic traits. We will include published peer-reviewed studies in both English and non-English language.INFORMATION SOURCES:Articles will be located in the NCBI PubMed, Embase, Scopus, Web of Science and LILACS databases, supplemented with manual searching of reference lists and articles citing the included studies. Risk of bias assessment: Risk of bias in individual studies will be assessed using tools from the Navigation Guide systematic review methodology, while the risk of bias at the outcome level will be assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) guidelines. Data synthesis and analysis: When studies are sufficiently similar in population, exposure, comparator and effect estimate to meaningfully allow quantitative synthesis, we will perform meta-analysis. Otherwise, results will be summarized qualitatively.FUNDING:The authors are paid employees of their respective institutions. MRHH is a Ph.D. student working under grants from Aarhus University and the National Research Centre for the Working Environment.REGISTRATION:PROSPERO CRD42017068861.

AB - OBJECTIVES:To assess whether exposure to specific classes of neuroactive non-organochlorine insecticides is associated with diabetes mellitus or related metabolic traits.METHODS:Eligibility criteria: Any type of epidemiological and human exposure studies providing an exposure contrast to neuroactive non-organochlorine insecticides and a measure of association to diabetes mellitus or related metabolic traits. We will include published peer-reviewed studies in both English and non-English language.INFORMATION SOURCES:Articles will be located in the NCBI PubMed, Embase, Scopus, Web of Science and LILACS databases, supplemented with manual searching of reference lists and articles citing the included studies. Risk of bias assessment: Risk of bias in individual studies will be assessed using tools from the Navigation Guide systematic review methodology, while the risk of bias at the outcome level will be assessed according to the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) guidelines. Data synthesis and analysis: When studies are sufficiently similar in population, exposure, comparator and effect estimate to meaningfully allow quantitative synthesis, we will perform meta-analysis. Otherwise, results will be summarized qualitatively.FUNDING:The authors are paid employees of their respective institutions. MRHH is a Ph.D. student working under grants from Aarhus University and the National Research Centre for the Working Environment.REGISTRATION:PROSPERO CRD42017068861.

KW - pesticid

KW - insekticid

KW - sprøjtegift

KW - insektmiddel

KW - plantebeskyttelsesmiddel

KW - diabetes

KW - sukkersyge

KW - diabetes mellitus

KW - blood glucose

KW - Hyperglycaemia

KW - pesticide

KW - insecticide

U2 - 10.1016/j.envint.2019.02.074

DO - 10.1016/j.envint.2019.02.074

M3 - Journal article

C2 - 30991222

VL - 127

SP - 664

EP - 670

JO - Environment International

JF - Environment International

SN - 0160-4120

ER -