Department of Economics and Business Economics

Exposure to ambient air pollution during childhood and subsequent risk of self-harm: A national cohort study

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Exposure to ambient air pollution during childhood and subsequent risk of self-harm : A national cohort study. / Mok, Pearl L H; Antonsen, Sussie; Agerbo, Esben; Brandt, Jørgen; Geels, Camilla; Christensen, Jesper H; Frohn, Lise M; Pedersen, Carsten B; Webb, Roger T.

In: Preventive Medicine, Vol. 152, No. Part 1, 11.2021, p. 106502.

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@article{deb9fc7d0a8d44d882abfe9ea2d64ac1,
title = "Exposure to ambient air pollution during childhood and subsequent risk of self-harm: A national cohort study",
abstract = "A growing body of evidence indicates that exposure to air pollution not only impacts on physical health but is also linked with a deterioration in mental health. We conducted the first study to investigate exposure to ambient particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) and nitrogen dioxide (NO2) during childhood and subsequent self-harm risk. The study cohort included persons born in Denmark between January 1, 1979 and December 31, 2006 (N = 1,424,670), with information on daily exposures to PM2.5 and NO2 at residence from birth to 10th birthday. Follow-up began from 10th birthday until first hospital-presenting self-harm episode, death, or December 31, 2016, whichever came first. Incidence rate ratios estimated by Poisson regression models revealed a dose relationship between increasing PM2.5 exposure and rising self-harm risk. Exposure to 17-19 μg/m3 of PM2.5 on average per day from birth to 10th birthday was associated with a 1.45 fold (95% CI 1.37-1.53) subsequently elevated self-harm risk compared with a mean daily exposure of <13 μg/m3, whilst those exposed to 19 μg/m3 or above on average per day had a 1.59 times (1.45-1.75) elevated risk. Higher mean daily exposure to NO2 during childhood was also linked with increased self-harm risk, but the dose-response relationship observed was less evident than for PM2.5. Covariate adjustment attenuated the associations, but risk remained independently elevated. Although causality cannot be assumed, these novel findings indicate a potential etiological involvement of ambient air pollution in the development of mental ill health.",
author = "Mok, {Pearl L H} and Sussie Antonsen and Esben Agerbo and J{\o}rgen Brandt and Camilla Geels and Christensen, {Jesper H} and Frohn, {Lise M} and Pedersen, {Carsten B} and Webb, {Roger T}",
note = "Copyright {\textcopyright} 2021. Published by Elsevier Inc.",
year = "2021",
month = nov,
doi = "10.1016/j.ypmed.2021.106502",
language = "English",
volume = "152",
pages = "106502",
journal = "Preventive Medicine",
issn = "0091-7435",
publisher = "Elsevier BV",
number = "Part 1",

}

RIS

TY - JOUR

T1 - Exposure to ambient air pollution during childhood and subsequent risk of self-harm

T2 - A national cohort study

AU - Mok, Pearl L H

AU - Antonsen, Sussie

AU - Agerbo, Esben

AU - Brandt, Jørgen

AU - Geels, Camilla

AU - Christensen, Jesper H

AU - Frohn, Lise M

AU - Pedersen, Carsten B

AU - Webb, Roger T

N1 - Copyright © 2021. Published by Elsevier Inc.

PY - 2021/11

Y1 - 2021/11

N2 - A growing body of evidence indicates that exposure to air pollution not only impacts on physical health but is also linked with a deterioration in mental health. We conducted the first study to investigate exposure to ambient particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) and nitrogen dioxide (NO2) during childhood and subsequent self-harm risk. The study cohort included persons born in Denmark between January 1, 1979 and December 31, 2006 (N = 1,424,670), with information on daily exposures to PM2.5 and NO2 at residence from birth to 10th birthday. Follow-up began from 10th birthday until first hospital-presenting self-harm episode, death, or December 31, 2016, whichever came first. Incidence rate ratios estimated by Poisson regression models revealed a dose relationship between increasing PM2.5 exposure and rising self-harm risk. Exposure to 17-19 μg/m3 of PM2.5 on average per day from birth to 10th birthday was associated with a 1.45 fold (95% CI 1.37-1.53) subsequently elevated self-harm risk compared with a mean daily exposure of <13 μg/m3, whilst those exposed to 19 μg/m3 or above on average per day had a 1.59 times (1.45-1.75) elevated risk. Higher mean daily exposure to NO2 during childhood was also linked with increased self-harm risk, but the dose-response relationship observed was less evident than for PM2.5. Covariate adjustment attenuated the associations, but risk remained independently elevated. Although causality cannot be assumed, these novel findings indicate a potential etiological involvement of ambient air pollution in the development of mental ill health.

AB - A growing body of evidence indicates that exposure to air pollution not only impacts on physical health but is also linked with a deterioration in mental health. We conducted the first study to investigate exposure to ambient particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) and nitrogen dioxide (NO2) during childhood and subsequent self-harm risk. The study cohort included persons born in Denmark between January 1, 1979 and December 31, 2006 (N = 1,424,670), with information on daily exposures to PM2.5 and NO2 at residence from birth to 10th birthday. Follow-up began from 10th birthday until first hospital-presenting self-harm episode, death, or December 31, 2016, whichever came first. Incidence rate ratios estimated by Poisson regression models revealed a dose relationship between increasing PM2.5 exposure and rising self-harm risk. Exposure to 17-19 μg/m3 of PM2.5 on average per day from birth to 10th birthday was associated with a 1.45 fold (95% CI 1.37-1.53) subsequently elevated self-harm risk compared with a mean daily exposure of <13 μg/m3, whilst those exposed to 19 μg/m3 or above on average per day had a 1.59 times (1.45-1.75) elevated risk. Higher mean daily exposure to NO2 during childhood was also linked with increased self-harm risk, but the dose-response relationship observed was less evident than for PM2.5. Covariate adjustment attenuated the associations, but risk remained independently elevated. Although causality cannot be assumed, these novel findings indicate a potential etiological involvement of ambient air pollution in the development of mental ill health.

U2 - 10.1016/j.ypmed.2021.106502

DO - 10.1016/j.ypmed.2021.106502

M3 - Journal article

C2 - 34538368

VL - 152

SP - 106502

JO - Preventive Medicine

JF - Preventive Medicine

SN - 0091-7435

IS - Part 1

ER -