Exploring the potential link between ΔFosB and N-acetylcysteine in craving/relapse dynamics: can N-acetylcysteine stand out as a possible treatment candidate?

Shokouh Arjmand; Mehran Ilaghi; Mohammad Shafie’ei; Pedro Gobira; Rodrigo Grassi-Oliveira; Gregers Wegener

doi:10.1017/neu.2024.38

Exploring the potential link between ΔFosB and N-acetylcysteine in craving/relapse dynamics: can N-acetylcysteine stand out as a possible treatment candidate?

Shokouh Arjmand, Mehran Ilaghi, Mohammad Shafie’ei, Pedro Gobira, Rodrigo Grassi-Oliveira, Gregers Wegener

Department of Clinical Medicine - Translational Neuropsychiatry Unit

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

From a neuroscientific point of view, one of the unique archetypes of substance use disorders is its road to relapse, in which the reward system plays a crucial role. Studies on the neurobiology of substance use disorders have highlighted the central role of a protein belonging to the Fos family of transcription factors, ΔFosB. Relying on the roles ΔFosB plays in the pathophysiology of substance use disorders, we endeavour to present some evidence demonstrating that N-acetylcysteine, a low-cost and well-tolerated over-the-counter medicine, may influence the downstream pathway of ΔFosB, thereby serving as a treatment strategy to mitigate the risk of relapse in cases of substance use.

Original language	English
Journal	Acta Neuropsychiatrica
Pages (from-to)	1-14
Number of pages	14
ISSN	0924-2708
DOIs	https://doi.org/10.1017/neu.2024.38
Publication status	E-pub ahead of print - 17 Oct 2024

Keywords

N-acetylcysteine
reinstatement
relapse
substance use disorders
ΔFosB

Access to Document

10.1017/neu.2024.38

https://www.cambridge.org/core/product/EC6C2FF93B4A6AECCF6181D20D06B63D

Cite this

@article{9dc7b7df84474835827b6539febd7e93,

title = "Exploring the potential link between ΔFosB and N-acetylcysteine in craving/relapse dynamics: can N-acetylcysteine stand out as a possible treatment candidate?",

abstract = "From a neuroscientific point of view, one of the unique archetypes of substance use disorders is its road to relapse, in which the reward system plays a crucial role. Studies on the neurobiology of substance use disorders have highlighted the central role of a protein belonging to the Fos family of transcription factors, ΔFosB. Relying on the roles ΔFosB plays in the pathophysiology of substance use disorders, we endeavour to present some evidence demonstrating that N-acetylcysteine, a low-cost and well-tolerated over-the-counter medicine, may influence the downstream pathway of ΔFosB, thereby serving as a treatment strategy to mitigate the risk of relapse in cases of substance use.",

keywords = "N-acetylcysteine, reinstatement, relapse, substance use disorders, ΔFosB",

author = "Shokouh Arjmand and Mehran Ilaghi and Mohammad Shafie{\textquoteright}ei and Pedro Gobira and Rodrigo Grassi-Oliveira and Gregers Wegener",

year = "2024",

month = oct,

day = "17",

doi = "10.1017/neu.2024.38",

language = "English",

pages = "1--14",

journal = "Acta Neuropsychiatrica",

issn = "0924-2708",

publisher = "Cambridge University Press",

}

Exploring the potential link between ΔFosB and N-acetylcysteine in craving/relapse dynamics: can N-acetylcysteine stand out as a possible treatment candidate? / Arjmand, Shokouh; Ilaghi, Mehran; Shafie’ei, Mohammad et al.
In: Acta Neuropsychiatrica, 17.10.2024, p. 1-14.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review