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Evidence that acute hyperinsulinaemia increases the cytokine content in essential organs after an endotoxin challenge in a porcine model

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Insulin has anti-inflammatory effects, as evaluated by its ability to reduce the plasma concentrations of cytokines. However, the inflammatory processing at the organ level is far less well established. The cytokine content in several organs after endotoxin (lipopolysaccharide, LPS) exposure and the effect of hyperinsulinaemia was examined.
Original languageEnglish
JournalActa Anaesthesiologica Scandinavica
Pages (from-to)1429-35
Number of pages7
Publication statusPublished - 2005

    Research areas

  • Animals, Blood Glucose, Cytokines, Endotoxins, Fatty Acids, Nonesterified, Female, Hyperinsulinism, Insulin, Lipopolysaccharides, RNA, Messenger, Reverse Transcriptase Polymerase Chain Reaction, Swine, Tissue Distribution

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