Evidence of No Association Between Human Papillomavirus and Breast Cancer

Sara Bønløkke; Jan Blaakær; Torben Steiniche; Estrid Hogdall; Steffen Grann-Jensen; Anne  Hammer; Eva Balslev; Michael Lenz Strube; Helle Knakkergaard; Susan Lenz

doi:10.3389/fonc.2018.00209

Evidence of No Association Between Human Papillomavirus and Breast Cancer

Sara Bønløkke, Jan Blaakær, Torben Steiniche, Estrid Hogdall, Steffen Grann-Jensen, Anne Hammer, Eva Balslev, Michael Lenz Strube, Helle Knakkergaard, Susan Lenz

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

21 Citations (Scopus)

Abstract

Background: Globally, breast cancer is the most frequent cancer among women. Studies reported an increased risk of breast cancer among women with prior cervical dysplasia. This study aimed to describe the prevalence of human papillomavirus (HPV) in breast cancer and explore if women with prior cervical neoplasia carry an increased risk of HPV-positive breast cancer compared to women without.

Methods: This case–control study identified 193 Danish women diagnosed with breast cancer (1998–2012) at Aarhus University Hospital or Copenhagen University Hospital Herlev. Cases were 93 women with cervical intraepithelial neoplasia grade 3 or worse (CIN3+) prior to breast cancer. Controls were 100 women without prior cervical dysplasia. HPV testing and genotyping were done using SPF10 PCR-DEIA-LiPA25 and an in-house semi-Q-PCR assay.

Results: Overall HPV prevalence in breast cancer for the assays was 1.55% (95% CI 0.32–4.48) and 0.52% (95% CI 0.01–2.85). There was no difference in HPV prevalence between cases and controls (2.15 vs. 1.00%, p = 0.61 and 1.08 vs. 0.00%, p = 0.48). HPV prevalence in CIN3+ was 94.62% (95% CI 0.88–0.98). Concordance between the assays was 98.60%.

Conclusion: HPV prevalence in breast cancer is very low suggesting no etiological correlation between HPV and breast cancer.

Original language	English
Article number	209
Journal	Frontiers in Oncology
Volume	8
Number of pages	8
ISSN	2234-943X
DOIs	https://doi.org/10.3389/fonc.2018.00209
Publication status	Published - Jun 2018

Keywords

Breast cancer
Cervical cancer
Denmark
HPV
Human papillomavirus
Pathology
Polymerase chain reaction

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title = "Evidence of No Association Between Human Papillomavirus and Breast Cancer",

abstract = "Background: Globally, breast cancer is the most frequent cancer among women. Studies reported an increased risk of breast cancer among women with prior cervical dysplasia. This study aimed to describe the prevalence of human papillomavirus (HPV) in breast cancer and explore if women with prior cervical neoplasia carry an increased risk of HPV-positive breast cancer compared to women without.Methods: This case–control study identified 193 Danish women diagnosed with breast cancer (1998–2012) at Aarhus University Hospital or Copenhagen University Hospital Herlev. Cases were 93 women with cervical intraepithelial neoplasia grade 3 or worse (CIN3+) prior to breast cancer. Controls were 100 women without prior cervical dysplasia. HPV testing and genotyping were done using SPF10 PCR-DEIA-LiPA25 and an in-house semi-Q-PCR assay.Results: Overall HPV prevalence in breast cancer for the assays was 1.55% (95% CI 0.32–4.48) and 0.52% (95% CI 0.01–2.85). There was no difference in HPV prevalence between cases and controls (2.15 vs. 1.00%, p = 0.61 and 1.08 vs. 0.00%, p = 0.48). HPV prevalence in CIN3+ was 94.62% (95% CI 0.88–0.98). Concordance between the assays was 98.60%.Conclusion: HPV prevalence in breast cancer is very low suggesting no etiological correlation between HPV and breast cancer.",

keywords = "Breast cancer, Cervical cancer, Denmark, HPV, Human papillomavirus, Pathology, Polymerase chain reaction",

author = "Sara B{\o}nl{\o}kke and Jan Blaak{\ae}r and Torben Steiniche and Estrid Hogdall and Steffen Grann-Jensen and Anne Hammer and Eva Balslev and Strube, {Michael Lenz} and Helle Knakkergaard and Susan Lenz",

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AU - Bønløkke, Sara

AU - Blaakær, Jan

AU - Steiniche, Torben

AU - Hogdall, Estrid

AU - Grann-Jensen, Steffen

AU - Hammer, Anne

AU - Balslev, Eva

AU - Strube, Michael Lenz

AU - Knakkergaard, Helle

AU - Lenz, Susan

PY - 2018/6

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N2 - Background: Globally, breast cancer is the most frequent cancer among women. Studies reported an increased risk of breast cancer among women with prior cervical dysplasia. This study aimed to describe the prevalence of human papillomavirus (HPV) in breast cancer and explore if women with prior cervical neoplasia carry an increased risk of HPV-positive breast cancer compared to women without.Methods: This case–control study identified 193 Danish women diagnosed with breast cancer (1998–2012) at Aarhus University Hospital or Copenhagen University Hospital Herlev. Cases were 93 women with cervical intraepithelial neoplasia grade 3 or worse (CIN3+) prior to breast cancer. Controls were 100 women without prior cervical dysplasia. HPV testing and genotyping were done using SPF10 PCR-DEIA-LiPA25 and an in-house semi-Q-PCR assay.Results: Overall HPV prevalence in breast cancer for the assays was 1.55% (95% CI 0.32–4.48) and 0.52% (95% CI 0.01–2.85). There was no difference in HPV prevalence between cases and controls (2.15 vs. 1.00%, p = 0.61 and 1.08 vs. 0.00%, p = 0.48). HPV prevalence in CIN3+ was 94.62% (95% CI 0.88–0.98). Concordance between the assays was 98.60%.Conclusion: HPV prevalence in breast cancer is very low suggesting no etiological correlation between HPV and breast cancer.

AB - Background: Globally, breast cancer is the most frequent cancer among women. Studies reported an increased risk of breast cancer among women with prior cervical dysplasia. This study aimed to describe the prevalence of human papillomavirus (HPV) in breast cancer and explore if women with prior cervical neoplasia carry an increased risk of HPV-positive breast cancer compared to women without.Methods: This case–control study identified 193 Danish women diagnosed with breast cancer (1998–2012) at Aarhus University Hospital or Copenhagen University Hospital Herlev. Cases were 93 women with cervical intraepithelial neoplasia grade 3 or worse (CIN3+) prior to breast cancer. Controls were 100 women without prior cervical dysplasia. HPV testing and genotyping were done using SPF10 PCR-DEIA-LiPA25 and an in-house semi-Q-PCR assay.Results: Overall HPV prevalence in breast cancer for the assays was 1.55% (95% CI 0.32–4.48) and 0.52% (95% CI 0.01–2.85). There was no difference in HPV prevalence between cases and controls (2.15 vs. 1.00%, p = 0.61 and 1.08 vs. 0.00%, p = 0.48). HPV prevalence in CIN3+ was 94.62% (95% CI 0.88–0.98). Concordance between the assays was 98.60%.Conclusion: HPV prevalence in breast cancer is very low suggesting no etiological correlation between HPV and breast cancer.

KW - Breast cancer

KW - Cervical cancer

KW - Denmark

KW - HPV

KW - Human papillomavirus

KW - Pathology

KW - Polymerase chain reaction

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DO - 10.3389/fonc.2018.00209

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VL - 8

JO - Frontiers in Oncology

JF - Frontiers in Oncology

M1 - 209

ER -

Evidence of No Association Between Human Papillomavirus and Breast Cancer

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