Evidence for cortical dysfunction in clinically non-demented patients with Parkinson's disease: A proton MR spectroscopy study

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • M. T.M. Hu, Hammersmith Hospital, King's College and King's College Hospital
  • ,
  • S. D. Taylor-Robinson, Hammersmith Hospital
  • ,
  • K. Ray Chaudhuri, King's College and King's College Hospital
  • ,
  • J. D. Bell, Hammersmith Hospital
  • ,
  • R. G. Morris, King's College and King's College Hospital
  • ,
  • C. Clough, King's College and King's College Hospital
  • ,
  • D. J. Brooks
  • N. Turjanski, Hammersmith Hospital

Objectives - To investigate whether proton magnetic resonance spectroscopy (1H MRS) can detect cortical dysfunction in non-demented patients with Parkinson's disease, and to correlate changes with cognitive function on formal neuropsychological testing. Methods - Multivoxel 1H MRS was performed in 17 patients with levodopa treated idiopathic Parkinson's disease without clinical dementia, and 10 age matched control subjects. Measurements of N-acetylaspartate (NAA)/choline (Cho), NAA/creatine+phosphocreatine (Cr), and Cho/Cr were obtained from right and left temporoparietal cortex and occipital cortex. Fourteen patients with Parkinson's disease underwent a full battery of neuropsychological testing including performance and verbal subtests of the WAIS-R, Boston naming test, FAS test, and California verbal learning test. Results - There were significant temporoparietal cortex reductions in NAA/Cr ratios in right and left averaged spectra of the patients with Parkinson's disease (p = 0.012 after Bonferroni correction) and in spectra contralateral to the worst clinically affected limbs of the patients with Parkinson's disease compared with controls (p = 0.003 after Bonferroni correction). There was a significant correlation between reduction in NAA/Cr ratios and measures of global cognitive decline, occurring independently of motor impairment (p = 0.019). Conclusions - This study suggests that 1H MRS can detect temporoparietal cortical dysfunction in non-demented patients with Parkinson's disease. Further longitudinal studies are needed to investigate whether these 1H MRS changes are predictive of future cognitive impairment in the subset of patients with Parkinson's disease who go on to develop dementia, or occur as part of the normal Parkinson's disease process.

Original languageEnglish
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume67
Issue1
Pages (from-to)20-26
Number of pages7
ISSN0022-3050
DOIs
Publication statusPublished - 1 Jan 1999
Externally publishedYes

    Research areas

  • Magnetic resonance spectroscopy, Parkinson's disease

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