European guidelines on microscopic colitis: United European Gastroenterology and European Microscopic Colitis Group statements and recommendations

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

DOI

  • Stephan Miehlke, Center for Digestive Diseases, Internal Medicine, Hamburg, Germany
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  • Danila Guagnozzi, Department of Nephrology, Hospital Universitari Vall d'Hebron, Nephrology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.
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  • Yamile Zabana, Hospital General Universitario de Alicante and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Alicante, Spain.
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  • Gian E Tontini, Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, San Raffaele Scientific Institute, Milan, Italy.
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  • Anne-Marie Kanstrup Fiehn, 1Copenhagen University Hospital, Copenhagen, Denmark. 2Aarhus University Hospital, Aarhus, Denmark. 3University of Copenhagen, Copenhagen, Denmark. 4Odense University Hospital, Odense, Denmark.
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  • Signe Wildt, Innovational Counsil, Zealand University Hospital, Region Zealand
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  • Johan Bohr, Department of Cardiology, Örebro University Hospital, Örebro
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  • Ole Bonderup
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  • Gerd Bouma, Division of Gastroenterology and Hepatology, Department of Medicine, University of British Columbia, British Columbia, CanadaDivision of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Alberta, Canada
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  • Mauro D'Amato, Monash Med Ctr, Monash University, Monash Heart
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  • Peter Johan Heiberg Engel, Innovational Counsil, Zealand University Hospital, Region Zealand
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  • Fernando Fernandez-Banares, Hospital General Universitario de Alicante and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Alicante, Spain.
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  • Gilles Macaigne, Centre Hospitalier de Marne-la-Vallée
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  • Henrik Hjortswang, Department of Infectious Diseases, Linköping University Hospital, Linköping, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
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  • Elisabeth Hultgren-Hörnquist, Department of Cardiology, Örebro University Hospital, Örebro
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  • Anastasios Koulaouzidis, The Royal Infirmary of Edinburgh
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  • Jouzas Kupcinskas, Lithuanian University of Health Sciences
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  • Stefania Landolfi, Vall dHebron Univ Hosp, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut d'Oncologia (VHIO), Dept Med Oncol
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  • Giovanni Latella, Department of Pediatrics University of L'Aquila L'Aquila Italy.
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  • Alfredo Lucendo, Hospital General de Tomelloso
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  • Ivan Lyutakov, Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University of Sofia, Sofia, 1504, Bulgaria.
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  • Ahmed Madisch, Department of Gastroenterology and Department of Pediatric Gastroenterology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
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  • Fernando Magro, Ctr Hosp Sao Joao, Sao Joao Hospital, Universidade do Porto, Pulmonol, Fac Med Porto
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  • Wojciech Marlicz, Pomeranian Med Univ, Pomeranian Medical University
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  • Emese Mihaly, Semmelweis Univ, Semmelweis University, Dept Vasc Surg
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  • Lars Kristian Munck, Innovational Counsil, Zealand University Hospital, Region Zealand
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  • Ann-Elisabeth Ostvik, Norwegian University for Science and Technology (NTNU)
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  • Árpád V Patai, Semmelweis Univ, Semmelweis University, Dept Vasc Surg
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  • Plamen Penchev, Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical Faculty, Medical University of Sofia, Sofia, 1504, Bulgaria.
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  • Karolina Skonieczna-Żydecka, Pomeranian Med Univ, Pomeranian Medical University
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  • Bas Verhaegh, Department of Intensive Care, Maastricht University Medical Center+, University Maastricht, Maastricht, the Netherlands.
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  • Andreas Münch, Department of Infectious Diseases, Linköping University Hospital, Linköping, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

INTRODUCTION: Microscopic colitis is a chronic inflammatory bowel disease characterised by normal or almost normal endoscopic appearance of the colon, chronic watery, non-bloody diarrhoea and distinct histological abnormalities, which identify three histological subtypes, the collagenous colitis, the lymphocytic colitis and the incomplete microscopic colitis. With ongoing uncertainties and new developments in the clinical management of microscopic colitis, there is a need for evidence-based guidelines to improve the medical care of patients suffering from this disorder.

METHODS: Guidelines were developed by members from the European Microscopic Colitis Group and United European Gastroenterology in accordance with the Appraisal of Guidelines for Research and Evaluation II instrument. Following a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation methodology was used to assess the certainty of the evidence. Statements and recommendations were developed by working groups consisting of gastroenterologists, pathologists and basic scientists, and voted upon using the Delphi method.

RESULTS: These guidelines provide information on epidemiology and risk factors of microscopic colitis, as well as evidence-based statements and recommendations on diagnostic criteria and treatment options, including oral budesonide, bile acid binders, immunomodulators and biologics. Recommendations on the clinical management of microscopic colitis are provided based on evidence, expert opinion and best clinical practice.

CONCLUSION: These guidelines may support clinicians worldwide to improve the clinical management of patients with microscopic colitis.

Original languageEnglish
JournalUnited European Gastroenterology Journal
Volume9
Issue1
Pages (from-to)13-37
Number of pages25
ISSN2050-6406
DOIs
Publication statusPublished - Feb 2021

    Research areas

  • Microscopic colitis, budesonide, diarrhoea, inflammatory bowel disease

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