European Expert Consensus on Practical Management of Specific Aspects of Parathyroid Disorders in Adults and in Pregnancy: recommendations of the ESE Educational Program of Parathyroid Disorders (PARAT 2021)

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

DOI

  • Jens Bollerslev, J Bollerslev, Section of Specialized Endocrinology, Oslo University Hospital, Oslo, 0027, Norway., Section of Specialized Endocrinology, Medical Clinic, University of Oslo
  • ,
  • Lars Rejnmark
  • Alexandra Zahn, A Zahn
  • ,
  • Ansgar Heck, University of Oslo
  • ,
  • N M Appelman-Dijkstra, N Appelman-Dijkstra
  • ,
  • Luis Cardoso, Centro Hospitalar e Universitário de Coimbra EPE
  • ,
  • Fadil M Hannan, University of Oxford
  • ,
  • Filomena Cetani, Pisa Univ, University of Pisa, Dipartimento Med Clin & Sperimentale
  • ,
  • Anna Maria Formenti, Univ Vita Salute San Raffaele, Vita-Salute San Raffaele University, Dept Neurol, San Raffaele Sci Inst
  • ,
  • Sigridur Björnsdottir, Karolinska Institutet
  • ,
  • Camilla Schalin-Jantti, University of Helsinki
  • ,
  • Zhanna Belaya, University of Southern Denmark
  • ,
  • Fraser Wilson Gibb, F Gibb
  • ,
  • Bruno Lapauw, Ghent University
  • ,
  • Karin Amrein, Cancer Biology Unit, Department of Dermatology, Medical University of Graz, Graz, Austria; Center for Medical Research, Medical University of Graz, Graz, Austria.
  • ,
  • Corinna Wicke, Academic Center for Thyroid Diseases
  • ,
  • Corinna Grasemann, Ruhr University of Bochum Faculty of Medicine
  • ,
  • Michael Krebs, Medical University of Vienna
  • ,
  • Eeva M Ryhänen, University of Helsinki
  • ,
  • Ozer Makay, Ege Univ Hosp, Ege University, Dept Pulmonol
  • ,
  • Salvatore Minisola, University of Rome La Sapienza
  • ,
  • Sebastien Gaujoux, S Gaujoux
  • ,
  • Jean-Philippe Bertocchio, Department of Cardiology, University Hospital Pitié-Salpêtrière, Paris, France.
  • ,
  • Zaki K Hassan-Smith, University Hospitals Birmingham, Birmingham, UK.
  • ,
  • Agnès Linglart, Department of Gastroenterology, University Hospital of Bicêtre, Assistance Publique - Hôpitaux de Paris, Université Paris-Sud, Le Kremlin Bicêtre, France.
  • ,
  • Elizabeth M Winter, Leiden University
  • ,
  • Martina Kollmann, Cancer Biology Unit, Department of Dermatology, Medical University of Graz, Graz, Austria; Center for Medical Research, Medical University of Graz, Graz, Austria.
  • ,
  • Hans-Georg Zmierczak, Ghent Universitary Hospital
  • ,
  • Elena Tsourdi, Division of Rheumatology, Department of Medicine III, University Medical Center & Faculty of Medicine Carl Gustav Carus, Technical University of Dresden, Dresden, Germany.
  • ,
  • Stefan Pilz, Cancer Biology Unit, Department of Dermatology, Medical University of Graz, Graz, Austria; Center for Medical Research, Medical University of Graz, Graz, Austria.
  • ,
  • Heide Siggelkow, Georg-August-University Goettingen
  • ,
  • Neil J Gittoes, University Hospitals Birmingham, Birmingham, UK.
  • ,
  • Claudio Marcocci, Pisa Univ, University of Pisa, Dipartimento Med Clin & Sperimentale
  • ,
  • Peter Kamenicky, P Kamenicky
  • ,
  • T Sikjaer

This European expert consensus statement provides recommendations for the diagnosis and management of primary hyperparathyroidism (PHPT), chronic hypoparathyroidism in adults (HypoPT), and parathyroid disorders in relation to pregnancy and lactation. Specified areas of interest and unmet needs identified by experts at the second ESE Educational Program of Parathyroid Disorders in 2019 were discussed during two virtual workshops in 2021 and subsequently developed by working groups with interest in t he specified areas. PHPT is a common endocrine disease. However, its differential diagnosis of familial hypocal ciuric hypercalcemia (FHH), the definition and clinical course of normocalcemic PHPT, and the optimal management of its recurrence after surgery represents areas of uncertainty requiring clarifications. HypoPT is an orphan diseas e characterized by low calcium concentrations due to insufficient PTH secretion, most often secondary to neck surge ry. Prevention and prediction of surgical injury to the parathyroid glands are essential to limit the disease-related burden. Long-term treatment modalities including the place for PTH replacement therapy and the optimal biochemical monitoring and imaging surveillance for complications to treatment in chronic HypoPT need to be refined. The physiological changes in calcium metabolism occurring during pregnancy and lactation modify the clinical presentation and management of parathyroid disorders in these periods of life. Modern interdisciplinary approaches to PHPT and HypoPT in pregnant and lactating women and their newborn children are proposed. The recommendations on clinical management presented here will serve as background for further educational material aimed at a broader clinical audience and were developed with the focus on endocrinologists in training.

Original languageEnglish
JournalEuropean Journal of Endocrinology
Volume186
Issue2
Pages (from-to)R33-R63
ISSN0804-4643
DOIs
Publication statusPublished - Feb 2022

    Research areas

  • AMERICAN ASSOCIATION, BONE-MINERAL DENSITY, CALCITROPIC HORMONES, CALCIUM-SENSING RECEPTOR, FAMILIAL HYPOCALCIURIC HYPERCALCEMIA, LONG-TERM TREATMENT, PRIMARY HYPERPARATHYROIDISM, QUALITY-OF-LIFE, SECONDARY HYPERPARATHYROIDISM, VITAMIN-D

See relations at Aarhus University Citationformats

ID: 229978621