Estimation of SARS-CoV-2 infection fatality rate by age and comorbidity status using antibody screening of blood donors during the COVID-19 epidemic in Denmark

Kathrine Agergård Kaspersen; Lotte Aas Hindhede; Jens Kjærgaard Boldsen; Susan Mikkelsen; Lasse Skafte Vestergaard; Ann-Sofie Nicole Berthelsen; Ida Rask Moustsen-Helms; Dorte Kinggaard Holm; Anna Christine Nilsson; Susanne Gjørup Sækmose; Erik Sørensen; Lene Holm Harritshøj; Bitten Aagaard; Henrik Hjalgrim; Søren Thue Lillevang; Charlotte Sværke Jørgensen; Tyra Grove Krause; Henrik Ullum; Ole Birger Vestager Pedersen; Sisse Rye Ostrowski; Christian Erikstrup

doi:10.1093/infdis/jiab566

Estimation of SARS-CoV-2 infection fatality rate by age and comorbidity status using antibody screening of blood donors during the COVID-19 epidemic in Denmark

Kathrine Agergård Kaspersen^*, Lotte Aas Hindhede, Jens Kjærgaard Boldsen, Susan Mikkelsen, Lasse Skafte Vestergaard, Ann-Sofie Nicole Berthelsen, Ida Rask Moustsen-Helms, Dorte Kinggaard Holm, Anna Christine Nilsson, Susanne Gjørup Sækmose, Erik Sørensen, Lene Holm Harritshøj, Bitten Aagaard, Henrik Hjalgrim, Søren Thue Lillevang, Charlotte Sværke Jørgensen, Tyra Grove Krause, Henrik Ullum, Ole Birger Vestager Pedersen, Sisse Rye OstrowskiChristian Erikstrup

^*Corresponding author for this work

Department of Clinical Medicine - Department of Clinical Immunology

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

18 Citations (Scopus)

Abstract

Background: Studies presenting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) for healthy individuals are warranted. We estimate IFR by age and comorbidity status using data from a large serosurvey among Danish blood donors and nationwide data on coronavirus disease 2019 (COVID-19) mortality. Methods: Danish blood donors aged 17-69 years donating blood October 2020-February 2021 were tested with a commercial SARS-CoV-2 total antibody assay. IFR was estimated for weeks 11 to 42, 2020 and week 43, 2020 to week 6, 2021, representing the first 2 waves of COVID-19 epidemic in Denmark. Results: In total, 84944 blood donors were tested for antibodies. The seroprevalence was 2% in October 2020 and 7% in February 2021. Among 3898039 Danish residents aged 17-69 years, 249 deaths were recorded. The IFR was low for people <51 years without comorbidity during the 2 waves (combined IFR=3.36 per 100000 infections). The IFR was below 3‰ for people aged 61-69 years without comorbidity. IFR increased with age and comorbidity but declined from the first to second wave. Conclusions: In this nationwide study, the IFR was very low among people <51 years without comorbidity.

Original language	English
Journal	The Journal of Infectious Diseases
Volume	225
Issue	2
Pages (from-to)	219-228
Number of pages	10
ISSN	0022-1899
DOIs	https://doi.org/10.1093/infdis/jiab566
Publication status	Published - Jan 2022

Keywords

SARS-CoV-2
blood donors
infection fatality rate
seroprevalence
Antibodies, Viral/blood
SARS-CoV-2/isolation & purification
Comorbidity
Humans
Middle Aged
Male
Seroepidemiologic Studies
COVID-19/blood
Young Adult
Blood Donors
Denmark/epidemiology
Adolescent
Adult
Female
Aged

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10.1093/infdis/jiab566

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689980/pdf/jiab566.pdf

BERTHA: Big Data Centre for Environment and Health
Sabel, C. E. (Project coordinator)
01/03/2018 → 28/02/2024
Project: Research

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Kaspersen, K. A., Hindhede, L. A., Boldsen, J. K., Mikkelsen, S., Vestergaard, L. S., Berthelsen, A.-S. N., Moustsen-Helms, I. R., Holm, D. K., Nilsson, A. C., Sækmose, S. G., Sørensen, E., Harritshøj, L. H., Aagaard, B., Hjalgrim, H., Lillevang, S. T., Jørgensen, C. S., Krause, T. G., Ullum, H., Pedersen, O. B. V., ... Erikstrup, C. (2022). Estimation of SARS-CoV-2 infection fatality rate by age and comorbidity status using antibody screening of blood donors during the COVID-19 epidemic in Denmark. The Journal of Infectious Diseases, 225(2), 219-228. https://doi.org/10.1093/infdis/jiab566

@article{9f3e4f4dfc2e44b8bb67dcb4dfc224b3,

title = "Estimation of SARS-CoV-2 infection fatality rate by age and comorbidity status using antibody screening of blood donors during the COVID-19 epidemic in Denmark",

abstract = "Background: Studies presenting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) for healthy individuals are warranted. We estimate IFR by age and comorbidity status using data from a large serosurvey among Danish blood donors and nationwide data on coronavirus disease 2019 (COVID-19) mortality. Methods: Danish blood donors aged 17-69 years donating blood October 2020-February 2021 were tested with a commercial SARS-CoV-2 total antibody assay. IFR was estimated for weeks 11 to 42, 2020 and week 43, 2020 to week 6, 2021, representing the first 2 waves of COVID-19 epidemic in Denmark. Results: In total, 84944 blood donors were tested for antibodies. The seroprevalence was 2% in October 2020 and 7% in February 2021. Among 3898039 Danish residents aged 17-69 years, 249 deaths were recorded. The IFR was low for people <51 years without comorbidity during the 2 waves (combined IFR=3.36 per 100000 infections). The IFR was below 3‰ for people aged 61-69 years without comorbidity. IFR increased with age and comorbidity but declined from the first to second wave. Conclusions: In this nationwide study, the IFR was very low among people <51 years without comorbidity.",

keywords = "SARS-CoV-2, blood donors, infection fatality rate, seroprevalence, Antibodies, Viral/blood, SARS-CoV-2/isolation & purification, Comorbidity, Humans, Middle Aged, Male, Seroepidemiologic Studies, COVID-19/blood, Young Adult, Blood Donors, Denmark/epidemiology, Adolescent, Adult, Female, Aged",

author = "Kaspersen, {Kathrine Agerg{\aa}rd} and Hindhede, {Lotte Aas} and Boldsen, {Jens Kj{\ae}rgaard} and Susan Mikkelsen and Vestergaard, {Lasse Skafte} and Berthelsen, {Ann-Sofie Nicole} and Moustsen-Helms, {Ida Rask} and Holm, {Dorte Kinggaard} and Nilsson, {Anna Christine} and S{\ae}kmose, {Susanne Gj{\o}rup} and Erik S{\o}rensen and Harritsh{\o}j, {Lene Holm} and Bitten Aagaard and Henrik Hjalgrim and Lillevang, {S{\o}ren Thue} and J{\o}rgensen, {Charlotte Sv{\ae}rke} and Krause, {Tyra Grove} and Henrik Ullum and Pedersen, {Ole Birger Vestager} and Ostrowski, {Sisse Rye} and Christian Erikstrup",

year = "2022",

month = jan,

doi = "10.1093/infdis/jiab566",

language = "English",

volume = "225",

pages = "219--228",

journal = "The Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "2",

}

Kaspersen, KA, Hindhede, LA, Boldsen, JK , Mikkelsen, S, Vestergaard, LS, Berthelsen, A-SN, Moustsen-Helms, IR, Holm, DK, Nilsson, AC, Sækmose, SG, Sørensen, E, Harritshøj, LH, Aagaard, B, Hjalgrim, H, Lillevang, ST, Jørgensen, CS, Krause, TG, Ullum, H, Pedersen, OBV, Ostrowski, SR & Erikstrup, C 2022, 'Estimation of SARS-CoV-2 infection fatality rate by age and comorbidity status using antibody screening of blood donors during the COVID-19 epidemic in Denmark', The Journal of Infectious Diseases, vol. 225, no. 2, pp. 219-228. https://doi.org/10.1093/infdis/jiab566

Estimation of SARS-CoV-2 infection fatality rate by age and comorbidity status using antibody screening of blood donors during the COVID-19 epidemic in Denmark. / Kaspersen, Kathrine Agergård; Hindhede, Lotte Aas; Boldsen, Jens Kjærgaard et al.
In: The Journal of Infectious Diseases, Vol. 225, No. 2, 01.2022, p. 219-228.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Estimation of SARS-CoV-2 infection fatality rate by age and comorbidity status using antibody screening of blood donors during the COVID-19 epidemic in Denmark

AU - Kaspersen, Kathrine Agergård

AU - Hindhede, Lotte Aas

AU - Boldsen, Jens Kjærgaard

AU - Mikkelsen, Susan

AU - Vestergaard, Lasse Skafte

AU - Berthelsen, Ann-Sofie Nicole

AU - Moustsen-Helms, Ida Rask

AU - Holm, Dorte Kinggaard

AU - Nilsson, Anna Christine

AU - Sækmose, Susanne Gjørup

AU - Sørensen, Erik

AU - Harritshøj, Lene Holm

AU - Aagaard, Bitten

AU - Hjalgrim, Henrik

AU - Lillevang, Søren Thue

AU - Jørgensen, Charlotte Sværke

AU - Krause, Tyra Grove

AU - Ullum, Henrik

AU - Pedersen, Ole Birger Vestager

AU - Ostrowski, Sisse Rye

AU - Erikstrup, Christian

PY - 2022/1

Y1 - 2022/1

N2 - Background: Studies presenting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) for healthy individuals are warranted. We estimate IFR by age and comorbidity status using data from a large serosurvey among Danish blood donors and nationwide data on coronavirus disease 2019 (COVID-19) mortality. Methods: Danish blood donors aged 17-69 years donating blood October 2020-February 2021 were tested with a commercial SARS-CoV-2 total antibody assay. IFR was estimated for weeks 11 to 42, 2020 and week 43, 2020 to week 6, 2021, representing the first 2 waves of COVID-19 epidemic in Denmark. Results: In total, 84944 blood donors were tested for antibodies. The seroprevalence was 2% in October 2020 and 7% in February 2021. Among 3898039 Danish residents aged 17-69 years, 249 deaths were recorded. The IFR was low for people <51 years without comorbidity during the 2 waves (combined IFR=3.36 per 100000 infections). The IFR was below 3‰ for people aged 61-69 years without comorbidity. IFR increased with age and comorbidity but declined from the first to second wave. Conclusions: In this nationwide study, the IFR was very low among people <51 years without comorbidity.

AB - Background: Studies presenting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) for healthy individuals are warranted. We estimate IFR by age and comorbidity status using data from a large serosurvey among Danish blood donors and nationwide data on coronavirus disease 2019 (COVID-19) mortality. Methods: Danish blood donors aged 17-69 years donating blood October 2020-February 2021 were tested with a commercial SARS-CoV-2 total antibody assay. IFR was estimated for weeks 11 to 42, 2020 and week 43, 2020 to week 6, 2021, representing the first 2 waves of COVID-19 epidemic in Denmark. Results: In total, 84944 blood donors were tested for antibodies. The seroprevalence was 2% in October 2020 and 7% in February 2021. Among 3898039 Danish residents aged 17-69 years, 249 deaths were recorded. The IFR was low for people <51 years without comorbidity during the 2 waves (combined IFR=3.36 per 100000 infections). The IFR was below 3‰ for people aged 61-69 years without comorbidity. IFR increased with age and comorbidity but declined from the first to second wave. Conclusions: In this nationwide study, the IFR was very low among people <51 years without comorbidity.

KW - SARS-CoV-2

KW - blood donors

KW - infection fatality rate

KW - seroprevalence

KW - Antibodies, Viral/blood

KW - SARS-CoV-2/isolation & purification

KW - Comorbidity

KW - Humans

KW - Middle Aged

KW - Male

KW - Seroepidemiologic Studies

KW - COVID-19/blood

KW - Young Adult

KW - Blood Donors

KW - Denmark/epidemiology

KW - Adolescent

KW - Adult

KW - Female

KW - Aged

U2 - 10.1093/infdis/jiab566

DO - 10.1093/infdis/jiab566

M3 - Journal article

C2 - 34788834

SN - 0022-1899

VL - 225

SP - 219

EP - 228

JO - The Journal of Infectious Diseases

JF - The Journal of Infectious Diseases

IS - 2

ER -

Estimation of SARS-CoV-2 infection fatality rate by age and comorbidity status using antibody screening of blood donors during the COVID-19 epidemic in Denmark

Abstract

Keywords

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BERTHA: Big Data Centre for Environment and Health

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