Estimating the glomerular filtration rate using serum cystatin C levels in patients with spinal cord injuries

E J Erlandsen; Rikke Bod Middelhede Hansen; E Randers; L E Petersen; Jan Abrahamsen; I L Johannesen

doi:10.1038/sc.2012.52

Estimating the glomerular filtration rate using serum cystatin C levels in patients with spinal cord injuries

E J Erlandsen, Rikke Bod Middelhede Hansen, E Randers, L E Petersen, Jan Abrahamsen, I L Johannesen

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

33 Citations (Scopus)

Abstract

STUDY DESIGN: Prospective cohort study.

OBJECTIVES: To investigate the relationship between (51)chromium-ethylene-diamine-tetra-acetate ((51)Cr-EDTA) clearance, serum cystatin C (CysC), serum creatinine, creatinine clearance and estimated glomerular filtration rate (eGFR(MDRD), MDRD stands for modification of diet in renal disease) based on the serum creatinine in patients with complete or incomplete spinal cord injury (SCI) and to develop and evaluate a GFR-estimating equation using serum CysC.

SETTINGS: Spinal Cord Injury Unit, Viborg Regional Hospital, Viborg, Denmark.

METHODS: Ninety-eight men and 47 women with SCI were included in the study. Serum CysC levels were measured by an automated particle-enhanced nephelometric immunoassay, serum and urine creatinine levels were measured by an enzymatic method traceable to the IDMS creatinine reference method, and (51)Cr-EDTA clearance was measured by a multiple plasma sample method.

RESULTS: The area under the curves (AUCs) in the non-parametric receiver operating characteristics (ROC) plots for serum CysC were compared with serum creatinine and to eGFR(MDRD) and revealed a significant difference (P-value < 0.05) for all SCI patients. There was no significant difference between the AUC for serum CysC compared with the AUC for creatinine clearance. GFR (ml min(-1) per 1.73 m(2)) can be calculated from serum CysC values (mg l(-1)) using the equation eGFR(CysC) = 212·exp(0.914·CysC). The model accurately predicted the GFR of 88% of patients within ± 30% of the measured GFR, and it was able to predict the GFR of 50% of patients within ± 10% of the measured GFR.

CONCLUSION: In patients with SCI, GFR can be estimated independent of age, sex and muscle mass by a newly developed equation based on a single serum CysC value.

Original language	English
Journal	Spinal Cord
Volume	50
Issue	10
Pages (from-to)	778-83
Number of pages	6
ISSN	1362-4393
DOIs	https://doi.org/10.1038/sc.2012.52
Publication status	Published - Oct 2012

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Body Mass Index
Body Surface Area
Child
Cohort Studies
Creatinine
Cystatin C
Female
Glomerular Filtration Rate
Humans
Male
Middle Aged
Predictive Value of Tests
Prospective Studies
Spinal Cord Injuries
Young Adult

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@article{521d633f6a4b41d1ba96f217de9bd9bf,

title = "Estimating the glomerular filtration rate using serum cystatin C levels in patients with spinal cord injuries",

abstract = "STUDY DESIGN: Prospective cohort study.OBJECTIVES: To investigate the relationship between (51)chromium-ethylene-diamine-tetra-acetate ((51)Cr-EDTA) clearance, serum cystatin C (CysC), serum creatinine, creatinine clearance and estimated glomerular filtration rate (eGFR(MDRD), MDRD stands for modification of diet in renal disease) based on the serum creatinine in patients with complete or incomplete spinal cord injury (SCI) and to develop and evaluate a GFR-estimating equation using serum CysC.SETTINGS: Spinal Cord Injury Unit, Viborg Regional Hospital, Viborg, Denmark.METHODS: Ninety-eight men and 47 women with SCI were included in the study. Serum CysC levels were measured by an automated particle-enhanced nephelometric immunoassay, serum and urine creatinine levels were measured by an enzymatic method traceable to the IDMS creatinine reference method, and (51)Cr-EDTA clearance was measured by a multiple plasma sample method.RESULTS: The area under the curves (AUCs) in the non-parametric receiver operating characteristics (ROC) plots for serum CysC were compared with serum creatinine and to eGFR(MDRD) and revealed a significant difference (P-value < 0.05) for all SCI patients. There was no significant difference between the AUC for serum CysC compared with the AUC for creatinine clearance. GFR (ml min(-1) per 1.73 m(2)) can be calculated from serum CysC values (mg l(-1)) using the equation eGFR(CysC) = 212·exp(0.914·CysC). The model accurately predicted the GFR of 88\% of patients within ± 30\% of the measured GFR, and it was able to predict the GFR of 50\% of patients within ± 10\% of the measured GFR.CONCLUSION: In patients with SCI, GFR can be estimated independent of age, sex and muscle mass by a newly developed equation based on a single serum CysC value.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Body Mass Index, Body Surface Area, Child, Cohort Studies, Creatinine, Cystatin C, Female, Glomerular Filtration Rate, Humans, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Spinal Cord Injuries, Young Adult",

author = "Erlandsen, \{E J\} and Hansen, \{Rikke Bod Middelhede\} and E Randers and Petersen, \{L E\} and Jan Abrahamsen and Johannesen, \{I L\}",

year = "2012",

month = oct,

doi = "10.1038/sc.2012.52",

language = "English",

volume = "50",

pages = "778--83",

journal = "Spinal Cord",

issn = "1362-4393",

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Estimating the glomerular filtration rate using serum cystatin C levels in patients with spinal cord injuries. / Erlandsen, E J; Hansen, Rikke Bod Middelhede; Randers, E et al.
In: Spinal Cord, Vol. 50, No. 10, 10.2012, p. 778-83.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Estimating the glomerular filtration rate using serum cystatin C levels in patients with spinal cord injuries

AU - Erlandsen, E J

AU - Hansen, Rikke Bod Middelhede

AU - Randers, E

AU - Petersen, L E

AU - Abrahamsen, Jan

AU - Johannesen, I L

PY - 2012/10

Y1 - 2012/10

N2 - STUDY DESIGN: Prospective cohort study.OBJECTIVES: To investigate the relationship between (51)chromium-ethylene-diamine-tetra-acetate ((51)Cr-EDTA) clearance, serum cystatin C (CysC), serum creatinine, creatinine clearance and estimated glomerular filtration rate (eGFR(MDRD), MDRD stands for modification of diet in renal disease) based on the serum creatinine in patients with complete or incomplete spinal cord injury (SCI) and to develop and evaluate a GFR-estimating equation using serum CysC.SETTINGS: Spinal Cord Injury Unit, Viborg Regional Hospital, Viborg, Denmark.METHODS: Ninety-eight men and 47 women with SCI were included in the study. Serum CysC levels were measured by an automated particle-enhanced nephelometric immunoassay, serum and urine creatinine levels were measured by an enzymatic method traceable to the IDMS creatinine reference method, and (51)Cr-EDTA clearance was measured by a multiple plasma sample method.RESULTS: The area under the curves (AUCs) in the non-parametric receiver operating characteristics (ROC) plots for serum CysC were compared with serum creatinine and to eGFR(MDRD) and revealed a significant difference (P-value < 0.05) for all SCI patients. There was no significant difference between the AUC for serum CysC compared with the AUC for creatinine clearance. GFR (ml min(-1) per 1.73 m(2)) can be calculated from serum CysC values (mg l(-1)) using the equation eGFR(CysC) = 212·exp(0.914·CysC). The model accurately predicted the GFR of 88% of patients within ± 30% of the measured GFR, and it was able to predict the GFR of 50% of patients within ± 10% of the measured GFR.CONCLUSION: In patients with SCI, GFR can be estimated independent of age, sex and muscle mass by a newly developed equation based on a single serum CysC value.

AB - STUDY DESIGN: Prospective cohort study.OBJECTIVES: To investigate the relationship between (51)chromium-ethylene-diamine-tetra-acetate ((51)Cr-EDTA) clearance, serum cystatin C (CysC), serum creatinine, creatinine clearance and estimated glomerular filtration rate (eGFR(MDRD), MDRD stands for modification of diet in renal disease) based on the serum creatinine in patients with complete or incomplete spinal cord injury (SCI) and to develop and evaluate a GFR-estimating equation using serum CysC.SETTINGS: Spinal Cord Injury Unit, Viborg Regional Hospital, Viborg, Denmark.METHODS: Ninety-eight men and 47 women with SCI were included in the study. Serum CysC levels were measured by an automated particle-enhanced nephelometric immunoassay, serum and urine creatinine levels were measured by an enzymatic method traceable to the IDMS creatinine reference method, and (51)Cr-EDTA clearance was measured by a multiple plasma sample method.RESULTS: The area under the curves (AUCs) in the non-parametric receiver operating characteristics (ROC) plots for serum CysC were compared with serum creatinine and to eGFR(MDRD) and revealed a significant difference (P-value < 0.05) for all SCI patients. There was no significant difference between the AUC for serum CysC compared with the AUC for creatinine clearance. GFR (ml min(-1) per 1.73 m(2)) can be calculated from serum CysC values (mg l(-1)) using the equation eGFR(CysC) = 212·exp(0.914·CysC). The model accurately predicted the GFR of 88% of patients within ± 30% of the measured GFR, and it was able to predict the GFR of 50% of patients within ± 10% of the measured GFR.CONCLUSION: In patients with SCI, GFR can be estimated independent of age, sex and muscle mass by a newly developed equation based on a single serum CysC value.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Body Mass Index

KW - Body Surface Area

KW - Child

KW - Cohort Studies

KW - Creatinine

KW - Cystatin C

KW - Female

KW - Glomerular Filtration Rate

KW - Humans

KW - Male

KW - Middle Aged

KW - Predictive Value of Tests

KW - Prospective Studies

KW - Spinal Cord Injuries

KW - Young Adult

U2 - 10.1038/sc.2012.52

DO - 10.1038/sc.2012.52

M3 - Journal article

C2 - 22547045

SN - 1362-4393

VL - 50

SP - 778

EP - 783

JO - Spinal Cord

JF - Spinal Cord

IS - 10

ER -

Estimating the glomerular filtration rate using serum cystatin C levels in patients with spinal cord injuries

Abstract

Keywords

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