Abstract
In this perspective, we discuss the regulatory impact of nuclear RNA export and decay on messenger RNA (mRNA) functionality. It is well established that control of protein-coding gene expression in eukaryotes employs the regulated production of mRNA, its intra-cellular transfer to cytoplasmic ribosomes and final transcript degradation. Despite a rich body of literature on these events, an involvement of nuclear RNA decay systems remains largely unexplored. Instead, nuclear RNA degradation is often considered a quality control precaution engaged primarily in ridding cells of aberrantly processed transcripts and spurious non-coding RNA. Recent research from human and budding yeast cells, however, demonstrates that even protein-coding transcripts fall prey to nuclear decay and that this is countered by their nuclear export. Here, we outline the potential of nuclear polyA-binding proteins in tuning levels of cellular mRNA to maintain transcript homeostasis.
| Original language | English |
|---|---|
| Journal | Current Genetics |
| Volume | 65 |
| Issue | 2 |
| Pages (from-to) | 473-476 |
| Number of pages | 4 |
| ISSN | 0172-8083 |
| DOIs | |
| Publication status | Published - 2019 |
Keywords
- COMPLEX
- Nab2
- Nuclear RNA degradation
- Nuclear RNA export
- PABPN1
- PATHWAY
- PROTEIN
- QUALITY-CONTROL
- RETENTION
- RNC1
- TRANSCRIPTION
- Transcription termination
- YEAST