Erectile dysfunction is a common problem in interstitial lung diseases

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  • Andreas Fløe
  • Ole Hilberg, Department of Internal Medicine, Vejle Sygehus, Vejle, Denmark.
  • ,
  • Marlies Wijsenbeek, Dept. of Respiratory Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands, Univ Hosp Rotterdam, Erasmus University Rotterdam, Erasmus MC, Dept Pulm Dis, Erasmus Univ, Erasmus University Rotterdam, Dept Resp Med, Med Ctr, Denmark
  • Elisabeth Bendstrup
Introduction: Erectile dysfunction (ED) is related to chronic diseases, including COPD. The patho- genesis may involve chronic hypoxia, which is common in interstitial lung disease (ILD). We aimed to study the relationship between ILD and ED. Method: Male patients with ILD detected by high-resolution computed to- mography (HR-CT) and/or histopathological findings in a lung biopsy were prospectively enrolled at two Eu- ropean ILD centers. Participants were asked to fill in the International Index of Erectile Function questionnaire (Danish or Dutch version). Information on type of ILD, lung function tests, 6-minute walking test (6MWT), co-morbidities, medication and smoking history was obtained from patient records. Results: Of 82 enrolled pa- tients, 54 patients (65.9%) returned the questionnaire. Mean age was 66.8 years (SD: 9.03). Twenty-six patients (48.1%) had IPF. Overall, 38 (70.4%) had some degree of ED, thirty (56.6%) had moderate to severe ED, and 23 (43.4%) had severe ED. Low diffusion capacity and high body mass index showed a trend of increasing risk of moderate to severe ED. The risk increased with age (OR per 5-year increase=2.63 (1.25; 5.53)) and decreased with 6MWT distance (OR per 50 m increase=0.60 (0.41; 0.89). Only two patients (6.7%) received specific treatment with phosphodiesterase-5 inhibitors. Conclusion: Severe ED is a common problem in men with ILD, and is associated with poor walking distance and high age. Treatment coverage is low, and physicians should ad- dress this problem as a part of the routine care.
Original languageDanish
JournalSarcoidosis Vasculitis and Diffuse Lung Diseases
Publication statusPublished - 27 Mar 2017

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