ER-Phagy, ER Homeostasis, and ER Quality Control: Implications for Disease

Susan Ferro-Novick; Fulvio Reggiori; Jeffrey L Brodsky

doi:10.1016/j.tibs.2020.12.013

ER-Phagy, ER Homeostasis, and ER Quality Control: Implications for Disease

Susan Ferro-Novick, Fulvio Reggiori, Jeffrey L Brodsky

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

82 Citations (Scopus)

Abstract

Lysosomal degradation of endoplasmic reticulum (ER) fragments by autophagy, termed ER-phagy or reticulophagy, occurs under normal as well as stress conditions. The recent discovery of multiple ER-phagy receptors has stimulated studies on the roles of ER-phagy. We discuss how the ER-phagy receptors and the cellular components that work with these receptors mediate two important functions: ER homeostasis and ER quality control. We highlight that ER-phagy plays an important role in alleviating ER expansion induced by ER stress, and acts as an alternative disposal pathway for misfolded proteins. We suggest that the latter function explains the emerging connection between ER-phagy and disease. Additional ER-phagy-associated functions and important unanswered questions are also discussed.

Original language	English
Journal	Trends in Biochemical Sciences
Volume	46
Issue	8
Pages (from-to)	630-639
Number of pages	10
ISSN	0968-0004
DOIs	https://doi.org/10.1016/j.tibs.2020.12.013
Publication status	Published - Aug 2021
Externally published	Yes

Keywords

Autophagy
Endoplasmic Reticulum
Endoplasmic Reticulum Stress
Homeostasis
Membrane Proteins

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10.1016/j.tibs.2020.12.013

Cite this

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title = "ER-Phagy, ER Homeostasis, and ER Quality Control: Implications for Disease",

abstract = "Lysosomal degradation of endoplasmic reticulum (ER) fragments by autophagy, termed ER-phagy or reticulophagy, occurs under normal as well as stress conditions. The recent discovery of multiple ER-phagy receptors has stimulated studies on the roles of ER-phagy. We discuss how the ER-phagy receptors and the cellular components that work with these receptors mediate two important functions: ER homeostasis and ER quality control. We highlight that ER-phagy plays an important role in alleviating ER expansion induced by ER stress, and acts as an alternative disposal pathway for misfolded proteins. We suggest that the latter function explains the emerging connection between ER-phagy and disease. Additional ER-phagy-associated functions and important unanswered questions are also discussed.",

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language = "English",

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T1 - ER-Phagy, ER Homeostasis, and ER Quality Control

T2 - Implications for Disease

AU - Ferro-Novick, Susan

AU - Reggiori, Fulvio

AU - Brodsky, Jeffrey L

PY - 2021/8

Y1 - 2021/8

N2 - Lysosomal degradation of endoplasmic reticulum (ER) fragments by autophagy, termed ER-phagy or reticulophagy, occurs under normal as well as stress conditions. The recent discovery of multiple ER-phagy receptors has stimulated studies on the roles of ER-phagy. We discuss how the ER-phagy receptors and the cellular components that work with these receptors mediate two important functions: ER homeostasis and ER quality control. We highlight that ER-phagy plays an important role in alleviating ER expansion induced by ER stress, and acts as an alternative disposal pathway for misfolded proteins. We suggest that the latter function explains the emerging connection between ER-phagy and disease. Additional ER-phagy-associated functions and important unanswered questions are also discussed.

AB - Lysosomal degradation of endoplasmic reticulum (ER) fragments by autophagy, termed ER-phagy or reticulophagy, occurs under normal as well as stress conditions. The recent discovery of multiple ER-phagy receptors has stimulated studies on the roles of ER-phagy. We discuss how the ER-phagy receptors and the cellular components that work with these receptors mediate two important functions: ER homeostasis and ER quality control. We highlight that ER-phagy plays an important role in alleviating ER expansion induced by ER stress, and acts as an alternative disposal pathway for misfolded proteins. We suggest that the latter function explains the emerging connection between ER-phagy and disease. Additional ER-phagy-associated functions and important unanswered questions are also discussed.

KW - Autophagy

KW - Endoplasmic Reticulum

KW - Endoplasmic Reticulum Stress

KW - Homeostasis

KW - Membrane Proteins

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U2 - 10.1016/j.tibs.2020.12.013

DO - 10.1016/j.tibs.2020.12.013

M3 - Review

C2 - 33509650

SN - 0968-0004

VL - 46

SP - 630

EP - 639

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 8

ER -

ER-Phagy, ER Homeostasis, and ER Quality Control: Implications for Disease

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Keywords

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