Epigenetic architecture and miRNA: reciprocal regulators

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  • Erik Digman Wiklund, Denmark
  • Jørgen Kjems, Interdisciplinary Nanoscience Center, Denmark
  • Susan Clark, Garvan Institute of Medical Research, Australia
  • Department of Molecular Biology
Deregulation of epigenetic and microRNA (miRNA) pathways are emerging as key events in carcinogenesis. miRNA genes can be epigenetically regulated and miRNAs can themselves repress key enzymes that drive epigenetic remodeling. Epigenetic and miRNA functions are thus tightly interconnected and crucial for maintaining correct local and global genomic architecture and gene expression patterns, yet the underlying molecular mechanisms and their widespread effects remain poorly understood. Due to the tissue specificity, versatility and relative stability of miRNAs, these small non-coding RNAs (ncRNAs) are considered especially promising in clinical applications, and their biogenesis and function is a subject of active research. In this review, the current status of epigenetic miRNA regulation is summarized and future therapeutic prospects in the field are discussed with a focus on cancer.
Original languageEnglish
Pages (from-to)823-840
Publication statusPublished - 15 Dec 2010

    Research areas

  • cancer ␣ chromatin ␣ DNA methylation ␣ epigenetics ␣ gene regulation ␣ histone modification ␣ miRNA ␣ ncRNA ␣ transcriptional gene silencing

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