Enzymes as Key Features in Therapeutic Cell Mimicry

Fabian Robert Itel, Philipp Schattling, Yan Zhang, Brigitte Maria Stadler

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

Abstract

Cell mimicry is a nature inspired concept that aims to substitute for missing or lost (sub)cellular function. This review focuses on the latest advancements in the use of enzymes in cell mimicry for encapsulated catalysis and artificial motility in synthetic bottom-up assemblies with emphasis on the biological response in cell culture or more rarely in animal models. Entities across the length scale from nano-sized enzyme mimics, sub-micron sized artificial organelles and self-propelled particles (swimmers) to micron-sized artificial cells are discussed. Although the field remains in its infancy, the primary aim of this review is to illustrate the advent of nature-mimicking artificial molecules and assemblies on their way to become a complementary alternative to their role models for diverse biomedical purposes.

Original languageEnglish
JournalAdvanced Drug Delivery Reviews
Volume118
Pages (from-to)94-108
Number of pages15
ISSN0169-409X
DOIs
Publication statusPublished - Sept 2017

Keywords

  • Artificial cells
  • Artificial organelles
  • Enzymes
  • Self-propelled motility

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