Enzyme cascade reaction engineering

TY - CHAP

T1 - Enzyme cascade reaction engineering

AU - Petermeier, Philipp

AU - Kara, Selin

N1 - Publisher Copyright: © Springer Nature Switzerland AG 2021. All rights reserved.

PY - 2021/3/28

Y1 - 2021/3/28

N2 - Biocatalytic transformations are of growing interest due to their high chemo-, regio-, and enantioselectivity, sustainability, and biocompatibility. In order to build on these advantages, to reinforce them, and not to weaken them, as well as to ensure the fulfillment of economic framework conditions, it is important to harmonize the reaction with its best suitable reactor and operation mode. In this chapter, three ideal reactor types and their biocatalytic conversion equations are presented for different inhibition scenarios, facilitating the proper bioreactor selection. Important aspects in the implementation of an enzymatic cascade are discussed and the introduced equations are exemplarily illustrated for a cascade reaction. In order to highlight different emerging approaches for cascade engineering, miniaturized flow bioreactors are discussed, and examples of recent publications are presented.

AB - Biocatalytic transformations are of growing interest due to their high chemo-, regio-, and enantioselectivity, sustainability, and biocompatibility. In order to build on these advantages, to reinforce them, and not to weaken them, as well as to ensure the fulfillment of economic framework conditions, it is important to harmonize the reaction with its best suitable reactor and operation mode. In this chapter, three ideal reactor types and their biocatalytic conversion equations are presented for different inhibition scenarios, facilitating the proper bioreactor selection. Important aspects in the implementation of an enzymatic cascade are discussed and the introduced equations are exemplarily illustrated for a cascade reaction. In order to highlight different emerging approaches for cascade engineering, miniaturized flow bioreactors are discussed, and examples of recent publications are presented.

KW - Enzymatic process optimization

KW - Enzyme cascades

KW - Flow biocatalysis

KW - Kinetic modelling

KW - Michaelis-Menten kinetics

KW - Reactor configurations

UR - http://www.scopus.com/inward/record.url?scp=85110449502&partnerID=8YFLogxK

U2 - 10.1007/978-3-030-65718-5_7

DO - 10.1007/978-3-030-65718-5_7

M3 - Book chapter

AN - SCOPUS:85110449502

SN - 9783030657178

SP - 109

EP - 124

BT - Enzyme Cascade Design and Modelling

PB - Springer International Publishing

ER -