Department of Economics and Business Economics

Environmental pollution is associated with increased risk of psychiatric disorders in the US and Denmark

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Environmental pollution is associated with increased risk of psychiatric disorders in the US and Denmark. / Khan, Atif; Plana-Ripoll, Oleguer; Antonsen, Sussie; Brandt, Jørgen; Geels, Camilla; Landecker, Hannah; Sullivan, Patrick F; Pedersen, Carsten Bøcker; Rzhetsky, Andrey.

In: P L o S Biology (Online), Vol. 17, No. 8, 08.2019, p. 3000353.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

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Author

Khan, Atif ; Plana-Ripoll, Oleguer ; Antonsen, Sussie ; Brandt, Jørgen ; Geels, Camilla ; Landecker, Hannah ; Sullivan, Patrick F ; Pedersen, Carsten Bøcker ; Rzhetsky, Andrey. / Environmental pollution is associated with increased risk of psychiatric disorders in the US and Denmark. In: P L o S Biology (Online). 2019 ; Vol. 17, No. 8. pp. 3000353.

Bibtex

@article{7bc5e674144046aaa2c658de54418ec4,
title = "Environmental pollution is associated with increased risk of psychiatric disorders in the US and Denmark",
abstract = "The search for the genetic factors underlying complex neuropsychiatric disorders has proceeded apace in the past decade. Despite some advances in identifying genetic variants associated with psychiatric disorders, most variants have small individual contributions to risk. By contrast, disease risk increase appears to be less subtle for disease-predisposing environmental insults. In this study, we sought to identify associations between environmental pollution and risk of neuropsychiatric disorders. We present exploratory analyses of 2 independent, very large datasets: 151 million unique individuals, represented in a United States insurance claims dataset, and 1.4 million unique individuals documented in Danish national treatment registers. Environmental Protection Agency (EPA) county-level environmental quality indices (EQIs) in the US and individual-level exposure to air pollution in Denmark were used to assess the association between pollution exposure and the risk of neuropsychiatric disorders. These results show that air pollution is significantly associated with increased risk of psychiatric disorders. We hypothesize that pollutants affect the human brain via neuroinflammatory pathways that have also been shown to cause depression-like phenotypes in animal studies.",
author = "Atif Khan and Oleguer Plana-Ripoll and Sussie Antonsen and J{\o}rgen Brandt and Camilla Geels and Hannah Landecker and Sullivan, {Patrick F} and Pedersen, {Carsten B{\o}cker} and Andrey Rzhetsky",
year = "2019",
month = aug,
doi = "10.1371/journal.pbio.3000353",
language = "English",
volume = "17",
pages = "3000353",
journal = "P L o S Biology (Online)",
issn = "1545-7885",
publisher = "public library of science",
number = "8",

}

RIS

TY - JOUR

T1 - Environmental pollution is associated with increased risk of psychiatric disorders in the US and Denmark

AU - Khan, Atif

AU - Plana-Ripoll, Oleguer

AU - Antonsen, Sussie

AU - Brandt, Jørgen

AU - Geels, Camilla

AU - Landecker, Hannah

AU - Sullivan, Patrick F

AU - Pedersen, Carsten Bøcker

AU - Rzhetsky, Andrey

PY - 2019/8

Y1 - 2019/8

N2 - The search for the genetic factors underlying complex neuropsychiatric disorders has proceeded apace in the past decade. Despite some advances in identifying genetic variants associated with psychiatric disorders, most variants have small individual contributions to risk. By contrast, disease risk increase appears to be less subtle for disease-predisposing environmental insults. In this study, we sought to identify associations between environmental pollution and risk of neuropsychiatric disorders. We present exploratory analyses of 2 independent, very large datasets: 151 million unique individuals, represented in a United States insurance claims dataset, and 1.4 million unique individuals documented in Danish national treatment registers. Environmental Protection Agency (EPA) county-level environmental quality indices (EQIs) in the US and individual-level exposure to air pollution in Denmark were used to assess the association between pollution exposure and the risk of neuropsychiatric disorders. These results show that air pollution is significantly associated with increased risk of psychiatric disorders. We hypothesize that pollutants affect the human brain via neuroinflammatory pathways that have also been shown to cause depression-like phenotypes in animal studies.

AB - The search for the genetic factors underlying complex neuropsychiatric disorders has proceeded apace in the past decade. Despite some advances in identifying genetic variants associated with psychiatric disorders, most variants have small individual contributions to risk. By contrast, disease risk increase appears to be less subtle for disease-predisposing environmental insults. In this study, we sought to identify associations between environmental pollution and risk of neuropsychiatric disorders. We present exploratory analyses of 2 independent, very large datasets: 151 million unique individuals, represented in a United States insurance claims dataset, and 1.4 million unique individuals documented in Danish national treatment registers. Environmental Protection Agency (EPA) county-level environmental quality indices (EQIs) in the US and individual-level exposure to air pollution in Denmark were used to assess the association between pollution exposure and the risk of neuropsychiatric disorders. These results show that air pollution is significantly associated with increased risk of psychiatric disorders. We hypothesize that pollutants affect the human brain via neuroinflammatory pathways that have also been shown to cause depression-like phenotypes in animal studies.

U2 - 10.1371/journal.pbio.3000353

DO - 10.1371/journal.pbio.3000353

M3 - Journal article

C2 - 31430271

VL - 17

SP - 3000353

JO - P L o S Biology (Online)

JF - P L o S Biology (Online)

SN - 1545-7885

IS - 8

ER -