TY - JOUR
T1 - Environmental exposures and fecundability
T2 - The Norwegian Mother, Father, and Child Cohort study
AU - Grindstad, Thea
AU - Håberg, Siri E
AU - Basso, Olga
AU - Hanevik, Hans Ivar
AU - Caspersen, Ida H
AU - Arge, Lise A
AU - Ramlau-Hansen, Cecilia Høst
AU - Myrskyla, Mikko
AU - Magnus, Maria C
N1 - Copyright © 2024 The Authors. Published by Elsevier GmbH.. All rights reserved.
PY - 2025/1
Y1 - 2025/1
N2 - Previous studies have linked certain environmental exposures to reduced fecundability, influencing exposure recommendations. We continue to encounter numerous environmental exposures in our everyday lives, and further evidence is needed regarding their effects on fecundability. We evaluated associations between various self-reported environmental exposures and fecundability, measured as time to pregnancy, in 64,942 women and 53,219 men participating in the Norwegian Mother, Father, and Child Cohort study (MoBa). Women reported on 17, and men on 19, environmental exposures, including heavy metals, pesticides, paints, and radiation. Fecundability ratios (FR) were estimated using log-binomial regression, comparing likelihood of conception during a given menstrual cycle between exposed versus unexposed participants. About 50 % of women and 75 % of men reported minimum one environmental exposure. Exposure to any pesticide (FR 0.94 [95 % CI 0.91-0.98]), and frequent exposure to photographic chemicals (FR 0.84 [95 % CI: 0.73-0.96]), was associated with decreased fecundability in women. We also observed a tendency of a slightly higher fecundability among women and men exposed to disinfectants (FR 1.02 [95 % CI: 1.00-1.04] and 1.03 [95 % CI: 1.00-1.06], respectively). Our results suggests that exposure to pesticides and photographic chemicals could affect women's fecundability.
AB - Previous studies have linked certain environmental exposures to reduced fecundability, influencing exposure recommendations. We continue to encounter numerous environmental exposures in our everyday lives, and further evidence is needed regarding their effects on fecundability. We evaluated associations between various self-reported environmental exposures and fecundability, measured as time to pregnancy, in 64,942 women and 53,219 men participating in the Norwegian Mother, Father, and Child Cohort study (MoBa). Women reported on 17, and men on 19, environmental exposures, including heavy metals, pesticides, paints, and radiation. Fecundability ratios (FR) were estimated using log-binomial regression, comparing likelihood of conception during a given menstrual cycle between exposed versus unexposed participants. About 50 % of women and 75 % of men reported minimum one environmental exposure. Exposure to any pesticide (FR 0.94 [95 % CI 0.91-0.98]), and frequent exposure to photographic chemicals (FR 0.84 [95 % CI: 0.73-0.96]), was associated with decreased fecundability in women. We also observed a tendency of a slightly higher fecundability among women and men exposed to disinfectants (FR 1.02 [95 % CI: 1.00-1.04] and 1.03 [95 % CI: 1.00-1.06], respectively). Our results suggests that exposure to pesticides and photographic chemicals could affect women's fecundability.
KW - The Norwegian Mother
KW - Father and Child Cohort study (MoBa)
KW - Pregnancy cohort
KW - Medical birth registry of Norway (MBRN)
KW - Environmental exposures
KW - Pesticides
KW - Photographic chemicals
KW - Fecundability
KW - Time to pregnancy
UR - http://www.scopus.com/inward/record.url?scp=85209548360&partnerID=8YFLogxK
U2 - 10.1016/j.ijheh.2024.114492
DO - 10.1016/j.ijheh.2024.114492
M3 - Journal article
C2 - 39579600
SN - 1438-4639
VL - 263
JO - International Journal of Hygiene and Environmental Health
JF - International Journal of Hygiene and Environmental Health
M1 - 114492
ER -