TY - JOUR
T1 - Entering the Next Phase
T2 - Predicting Biological Effects of Biomolecular Condensates
AU - Davis, Maria C.
AU - André, Alain A.M.
AU - Kjaergaard, Magnus
PY - 2024/11/1
Y1 - 2024/11/1
N2 - Biomolecular condensates are increasingly recognized as important drivers of cellular function; their dysregulation leads to pathology and disease. We discuss three questions in terms of the impending utility of data-driven techniques to predict condensate-driven biological outcomes, i.e., the impact of cellular state changes on condensates, the effect of condensates on biochemical processes within, and condensate properties that result in cellular dysregulation and disease.
AB - Biomolecular condensates are increasingly recognized as important drivers of cellular function; their dysregulation leads to pathology and disease. We discuss three questions in terms of the impending utility of data-driven techniques to predict condensate-driven biological outcomes, i.e., the impact of cellular state changes on condensates, the effect of condensates on biochemical processes within, and condensate properties that result in cellular dysregulation and disease.
KW - biomolecular condensates
KW - emergent properties
KW - phase-separation regulation
KW - predictive machine learning
UR - http://www.scopus.com/inward/record.url?scp=85196377149&partnerID=8YFLogxK
U2 - 10.1016/j.jmb.2024.168645
DO - 10.1016/j.jmb.2024.168645
M3 - Journal article
C2 - 38848869
AN - SCOPUS:85196377149
SN - 0022-2836
VL - 436
JO - Journal of Molecular Biology
JF - Journal of Molecular Biology
IS - 21
M1 - 168645
ER -