Enhanced Photoresponsive Graphene Oxide-Modified g-C
                        3
                        N
                        4
                         for Disassembly of Amyloid β Fibrils

Jie Wang; Zhongyang Zhang; Hongxing Zhang; Chenglong Li; Menglin Chen; Lei Liu; Mingdong Dong

doi:10.1021/acsami.8b10343

Enhanced Photoresponsive Graphene Oxide-Modified g-C ₃ N ₄ for Disassembly of Amyloid β Fibrils

Jie Wang, Zhongyang Zhang, Hongxing Zhang, Chenglong Li, Menglin Chen, Lei Liu^*, Mingdong Dong

^*Corresponding author for this work

Interdisciplinary Nanoscience Center - INANO-Fysik, iNANO-huset

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

41 Citations (Scopus)

Abstract

Protein misfolding and abnormal self-assembly lead to the aggregates of oligomers, fibrils, or senior amyloid β (Aβ) plaques, which are associated with the pathogenesis of many neurodegenerative diseases. Progressive cerebral accumulation of Aβ protein was widely proposed to explain the cause of Alzheimer's disease, for which one promising direction of the preclinical study is to convert the preformed β-sheet structure of Aβ aggregates into innocent structures. However, the conversion is even harder than the modulation of the amyloidosis process. Herein, a graphene oxide/carbon nitride composite was developed as a good photocatalyst for irreversibly disassembling the Aβ aggregates of Aβ(33-42) under UV. Quartz crystal microbalance, circular dichroism spectrum, atomic force microscopy, fluorescent spectra, and mechanical property analysis were performed to analyze this photodegradation process from different aspects for fully understanding the mechanism, which may provide an important enlightenment for the relevant research in this field and neurodegenerative disease study.

Original language	English
Journal	ACS Applied Materials & Interfaces
Volume	11
Issue	1
Pages (from-to)	96-103
Number of pages	8
ISSN	1944-8244
DOIs	https://doi.org/10.1021/acsami.8b10343
Publication status	Published - 2019

Keywords

AGGREGATION
ALZHEIMERS-DISEASE
CARBON NANOTUBE
CYTOTOXICITY
INHIBITION
NANOMATERIALS
NANOSHEETS
PATHOLOGY
PEPTIDE
PHOTODEGRADATION
amyloid beta disassembly
atomic force microscopy
neurodegenerative disease
photodegradation
quartz crystal microbalance

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10.1021/acsami.8b10343

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title = "Enhanced Photoresponsive Graphene Oxide-Modified g-C 3 N 4 for Disassembly of Amyloid β Fibrils",

abstract = "Protein misfolding and abnormal self-assembly lead to the aggregates of oligomers, fibrils, or senior amyloid β (Aβ) plaques, which are associated with the pathogenesis of many neurodegenerative diseases. Progressive cerebral accumulation of Aβ protein was widely proposed to explain the cause of Alzheimer's disease, for which one promising direction of the preclinical study is to convert the preformed β-sheet structure of Aβ aggregates into innocent structures. However, the conversion is even harder than the modulation of the amyloidosis process. Herein, a graphene oxide/carbon nitride composite was developed as a good photocatalyst for irreversibly disassembling the Aβ aggregates of Aβ(33-42) under UV. Quartz crystal microbalance, circular dichroism spectrum, atomic force microscopy, fluorescent spectra, and mechanical property analysis were performed to analyze this photodegradation process from different aspects for fully understanding the mechanism, which may provide an important enlightenment for the relevant research in this field and neurodegenerative disease study.",

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author = "Jie Wang and Zhongyang Zhang and Hongxing Zhang and Chenglong Li and Menglin Chen and Lei Liu and Mingdong Dong",

year = "2019",

doi = "10.1021/acsami.8b10343",

language = "English",

volume = "11",

pages = "96--103",

journal = "ACS Applied Materials & Interfaces",

issn = "1944-8244",

publisher = "American Chemical Society",

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}

Enhanced Photoresponsive Graphene Oxide-Modified g-C ₃ N ₄ for Disassembly of Amyloid β Fibrils. / Wang, Jie; Zhang, Zhongyang; Zhang, Hongxing et al.
In: ACS Applied Materials & Interfaces, Vol. 11, No. 1, 2019, p. 96-103.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

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AU - Wang, Jie

AU - Zhang, Zhongyang

AU - Zhang, Hongxing

AU - Li, Chenglong

AU - Chen, Menglin

AU - Liu, Lei

AU - Dong, Mingdong

PY - 2019

Y1 - 2019

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AB - Protein misfolding and abnormal self-assembly lead to the aggregates of oligomers, fibrils, or senior amyloid β (Aβ) plaques, which are associated with the pathogenesis of many neurodegenerative diseases. Progressive cerebral accumulation of Aβ protein was widely proposed to explain the cause of Alzheimer's disease, for which one promising direction of the preclinical study is to convert the preformed β-sheet structure of Aβ aggregates into innocent structures. However, the conversion is even harder than the modulation of the amyloidosis process. Herein, a graphene oxide/carbon nitride composite was developed as a good photocatalyst for irreversibly disassembling the Aβ aggregates of Aβ(33-42) under UV. Quartz crystal microbalance, circular dichroism spectrum, atomic force microscopy, fluorescent spectra, and mechanical property analysis were performed to analyze this photodegradation process from different aspects for fully understanding the mechanism, which may provide an important enlightenment for the relevant research in this field and neurodegenerative disease study.

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KW - INHIBITION

KW - NANOMATERIALS

KW - NANOSHEETS

KW - PATHOLOGY

KW - PEPTIDE

KW - PHOTODEGRADATION

KW - amyloid beta disassembly

KW - atomic force microscopy

KW - neurodegenerative disease

KW - photodegradation

KW - quartz crystal microbalance

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M3 - Journal article

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AN - SCOPUS:85059749887

SN - 1944-8244

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JF - ACS Applied Materials & Interfaces

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Enhanced Photoresponsive Graphene Oxide-Modified g-C ₃ N ₄ for Disassembly of Amyloid β Fibrils

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Keywords

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