Enhanced electron transfer between gold nanoparticles and horseradish peroxidase reconstituted onto alkanethiol-modified hemin

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Robust molecular bioelectronic devices require a programmable and efficient electronic communication between biological molecules and electrodes. With proteins it is often compromised by their uncontrollable assembly on electrodes that does not provide neither uniform nor efficient electron flow between proteins and electrodes. Here, horseradish peroxidase reconstituted onto C-11-alkanethiol-conjugated hemin and self-assembled onto the gold nanoparticle (NP)-modified electrodes via the exposed alkanethiol tail exhibits enhanced electron transfer (ET), proceeding via the gold NP relay with the ET rate constant approaching 115 s(-1) vs. 14 s(-1) shown on bare gold, by this offering an advanced controllable design of interfaces for bioelectronic devices based on heme-containing enzymes with a non-covalently bound heme. (C) 2016 Elsevier B.V. All rights reserved.

Original languageEnglish
JournalElectrochemistry Communications
Volume70
Pages (from-to)39-42
Number of pages4
ISSN1388-2481
DOIs
Publication statusPublished - Sep 2016

    Research areas

  • Gold nanoparticles, Hemin, Peroxidase, Electron transfer, Reconstitution, DIRECT ELECTROCHEMISTRY, METAL NANOPARTICLES, SULFITE OXIDASE, REDOX ENZYMES, MONOLAYERS, BIOELECTROCATALYSIS, FLAVOHEMOGLOBIN, HEMOGLOBIN, REDUCTION, OXIDATION

See relations at Aarhus University Citationformats

ID: 103463570