Engineering Lipid-Based Pop-up Conductive Interfaces with PEDOT:PSS and Light-Responsive Azopolymer Films

Luca Terenzi; Ziyu Gao; Mehdi Ravandeh; Chiara Fedele; Lasse Hyldgaard Klausen; Claudia Latte Bovio; Arri Priimagi; Francesca Santoro

doi:10.1002/adhm.202303812

Engineering Lipid-Based Pop-up Conductive Interfaces with PEDOT:PSS and Light-Responsive Azopolymer Films

Luca Terenzi, Ziyu Gao, Mehdi Ravandeh, Chiara Fedele, Lasse Hyldgaard Klausen, Claudia Latte Bovio, Arri Priimagi, Francesca Santoro^*

^*Corresponding author for this work

Interdisciplinary Nanoscience Center - INANO-Fysik, iNANO-huset

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

Abstract

Significant challenges have emerged in the development of biomimetic electronic interfaces capable of dynamic interaction with living organisms and biological systems, including neurons, muscles, and sensory organs. Yet, there remains a need for interfaces that can function on demand, facilitating communication and biorecognition with living cells in bioelectronic systems. In this study, the design and engineering of a responsive and conductive material with cell-instructive properties, allowing for the modification of its topography through light irradiation, resulting in the formation of “pop-up structures”, is presented. A deformable substrate, composed of a bilayer comprising a light-responsive, azobenzene-containing polymer, pDR1m, and a conductive polymer, PEDOT:PSS, is fabricated and characterized. Moreover, the successful formation of supported lipid bilayers (SLBs) and the maintenance of integrity while deforming the pDR1m/PEDOT:PSS films represent promising advancements for future applications in responsive bioelectronics and neuroelectronic interfaces.

Original language	English
Article number	2303812
Journal	Advanced Healthcare Materials
Volume	13
Issue	24
ISSN	2192-2640
DOIs	https://doi.org/10.1002/adhm.202303812
Publication status	Published - 25 Sept 2024

Keywords

deformable bioelectronics
light-driven polymers
PEDOT:PSS
pop-up structures
supported lipid bilayers (SLBs)
surface relief grating

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10.1002/adhm.202303812

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title = "Engineering Lipid-Based Pop-up Conductive Interfaces with PEDOT:PSS and Light-Responsive Azopolymer Films",

abstract = "Significant challenges have emerged in the development of biomimetic electronic interfaces capable of dynamic interaction with living organisms and biological systems, including neurons, muscles, and sensory organs. Yet, there remains a need for interfaces that can function on demand, facilitating communication and biorecognition with living cells in bioelectronic systems. In this study, the design and engineering of a responsive and conductive material with cell-instructive properties, allowing for the modification of its topography through light irradiation, resulting in the formation of “pop-up structures”, is presented. A deformable substrate, composed of a bilayer comprising a light-responsive, azobenzene-containing polymer, pDR1m, and a conductive polymer, PEDOT:PSS, is fabricated and characterized. Moreover, the successful formation of supported lipid bilayers (SLBs) and the maintenance of integrity while deforming the pDR1m/PEDOT:PSS films represent promising advancements for future applications in responsive bioelectronics and neuroelectronic interfaces.",

keywords = "deformable bioelectronics, light-driven polymers, PEDOT:PSS, pop-up structures, supported lipid bilayers (SLBs), surface relief grating",

author = "Luca Terenzi and Ziyu Gao and Mehdi Ravandeh and Chiara Fedele and Klausen, {Lasse Hyldgaard} and Bovio, {Claudia Latte} and Arri Priimagi and Francesca Santoro",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH.",

year = "2024",

month = sep,

day = "25",

doi = "10.1002/adhm.202303812",

language = "English",

volume = "13",

journal = "Advanced Healthcare Materials",

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publisher = "Wiley - VCH Verlag GmbH & CO. KGaA",

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Engineering Lipid-Based Pop-up Conductive Interfaces with PEDOT:PSS and Light-Responsive Azopolymer Films. / Terenzi, Luca; Gao, Ziyu; Ravandeh, Mehdi et al.
In: Advanced Healthcare Materials, Vol. 13, No. 24, 2303812, 25.09.2024.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

TY - JOUR

T1 - Engineering Lipid-Based Pop-up Conductive Interfaces with PEDOT:PSS and Light-Responsive Azopolymer Films

AU - Terenzi, Luca

AU - Gao, Ziyu

AU - Ravandeh, Mehdi

AU - Fedele, Chiara

AU - Klausen, Lasse Hyldgaard

AU - Bovio, Claudia Latte

AU - Priimagi, Arri

AU - Santoro, Francesca

PY - 2024/9/25

Y1 - 2024/9/25

N2 - Significant challenges have emerged in the development of biomimetic electronic interfaces capable of dynamic interaction with living organisms and biological systems, including neurons, muscles, and sensory organs. Yet, there remains a need for interfaces that can function on demand, facilitating communication and biorecognition with living cells in bioelectronic systems. In this study, the design and engineering of a responsive and conductive material with cell-instructive properties, allowing for the modification of its topography through light irradiation, resulting in the formation of “pop-up structures”, is presented. A deformable substrate, composed of a bilayer comprising a light-responsive, azobenzene-containing polymer, pDR1m, and a conductive polymer, PEDOT:PSS, is fabricated and characterized. Moreover, the successful formation of supported lipid bilayers (SLBs) and the maintenance of integrity while deforming the pDR1m/PEDOT:PSS films represent promising advancements for future applications in responsive bioelectronics and neuroelectronic interfaces.

AB - Significant challenges have emerged in the development of biomimetic electronic interfaces capable of dynamic interaction with living organisms and biological systems, including neurons, muscles, and sensory organs. Yet, there remains a need for interfaces that can function on demand, facilitating communication and biorecognition with living cells in bioelectronic systems. In this study, the design and engineering of a responsive and conductive material with cell-instructive properties, allowing for the modification of its topography through light irradiation, resulting in the formation of “pop-up structures”, is presented. A deformable substrate, composed of a bilayer comprising a light-responsive, azobenzene-containing polymer, pDR1m, and a conductive polymer, PEDOT:PSS, is fabricated and characterized. Moreover, the successful formation of supported lipid bilayers (SLBs) and the maintenance of integrity while deforming the pDR1m/PEDOT:PSS films represent promising advancements for future applications in responsive bioelectronics and neuroelectronic interfaces.

KW - deformable bioelectronics

KW - light-driven polymers

KW - PEDOT:PSS

KW - pop-up structures

KW - supported lipid bilayers (SLBs)

KW - surface relief grating

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DO - 10.1002/adhm.202303812

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JF - Advanced Healthcare Materials

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Engineering Lipid-Based Pop-up Conductive Interfaces with PEDOT:PSS and Light-Responsive Azopolymer Films

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