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Endothelin-1 induces a strong pressor effect in ball pythons (Python regius)

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Endothelin-1 induces a strong pressor effect in ball pythons (Python regius). / Jensen, Maja Fuhlendorff; Nedergaard, Signe; Nielsen, Hang Nguyen et al.

In: Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology, Vol. 241, 110620, 03.2020.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Jensen, MF, Nedergaard, S, Nielsen, HN, Skovgaard, N, Stevnsner, TV & Wang, T 2020, 'Endothelin-1 induces a strong pressor effect in ball pythons (Python regius)', Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology, vol. 241, 110620. https://doi.org/10.1016/j.cbpa.2019.110620

APA

Jensen, M. F., Nedergaard, S., Nielsen, H. N., Skovgaard, N., Stevnsner, T. V., & Wang, T. (2020). Endothelin-1 induces a strong pressor effect in ball pythons (Python regius). Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology, 241, [110620]. https://doi.org/10.1016/j.cbpa.2019.110620

CBE

Jensen MF, Nedergaard S, Nielsen HN, Skovgaard N, Stevnsner TV, Wang T. 2020. Endothelin-1 induces a strong pressor effect in ball pythons (Python regius). Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology. 241:Article 110620. https://doi.org/10.1016/j.cbpa.2019.110620

MLA

Jensen, Maja Fuhlendorff et al. "Endothelin-1 induces a strong pressor effect in ball pythons (Python regius)". Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology. 2020. 241. https://doi.org/10.1016/j.cbpa.2019.110620

Vancouver

Jensen MF, Nedergaard S, Nielsen HN, Skovgaard N, Stevnsner TV, Wang T. Endothelin-1 induces a strong pressor effect in ball pythons (Python regius). Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology. 2020 Mar;241. 110620. https://doi.org/10.1016/j.cbpa.2019.110620

Author

Jensen, Maja Fuhlendorff ; Nedergaard, Signe ; Nielsen, Hang Nguyen et al. / Endothelin-1 induces a strong pressor effect in ball pythons (Python regius). In: Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology. 2020 ; Vol. 241.

Bibtex

@article{bb53d405e7f84167bc6d37ebfc344535,
title = "Endothelin-1 induces a strong pressor effect in ball pythons (Python regius)",
abstract = "Endothelin-1 (ET-1) is a very potent vasoactive peptide released from endothelial cells, and ET-1 plays an important role in the maintenance and regulation of blood pressure in mammals. ET-1 signaling is mediated by two receptors: ETA and ETB. In mammals, ETA receptors are located on vascular smooth muscle where they mediate vasoconstriction. ETB receptors located on the endothelium mediate vasodilatation through the release of nitric oxide, whereas stimulation of ETB receptors placed on vascular smooth muscle leads to vasoconstriction. Less is known about ET-1 signaling in reptiles. In anaesthetized alligators, ET-1 elicits a biphasic blood pressure with a long-lasting initial decrease followed by a smaller increase in systemic blood pressure. In anaesthetized freshwater turtles, ET-1 causes a dose-dependent systemic vasodilatation mediated through ETB receptors. In the present study, we investigated the cardiovascular effects of ET-1 on the systemic and pulmonary vasculature of pythons. The presence of ETA and ETB receptors in the vasculature of pythons was verified by means of immunoblotting. Myography on isolated vessels revealed a dose-dependent vasoconstrictory response to ET-1 in both mesenteric and pulmonary arteries. Pressure measurements in recovered specimens revealed an ET-1-induced rise in systemic blood pressure supporting our in vitro findings. In conclusion, our study shows that ET-1 induces a strong pressor effect in the systemic circulation.",
keywords = "Blood pressure, ET receptor, Myography, Reptile",
author = "Jensen, {Maja Fuhlendorff} and Signe Nedergaard and Nielsen, {Hang Nguyen} and Nini Skovgaard and Stevnsner, {Tinna V.} and Tobias Wang",
year = "2020",
month = mar,
doi = "10.1016/j.cbpa.2019.110620",
language = "English",
volume = "241",
journal = "Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology",
issn = "1095-6433",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Endothelin-1 induces a strong pressor effect in ball pythons (Python regius)

AU - Jensen, Maja Fuhlendorff

AU - Nedergaard, Signe

AU - Nielsen, Hang Nguyen

AU - Skovgaard, Nini

AU - Stevnsner, Tinna V.

AU - Wang, Tobias

PY - 2020/3

Y1 - 2020/3

N2 - Endothelin-1 (ET-1) is a very potent vasoactive peptide released from endothelial cells, and ET-1 plays an important role in the maintenance and regulation of blood pressure in mammals. ET-1 signaling is mediated by two receptors: ETA and ETB. In mammals, ETA receptors are located on vascular smooth muscle where they mediate vasoconstriction. ETB receptors located on the endothelium mediate vasodilatation through the release of nitric oxide, whereas stimulation of ETB receptors placed on vascular smooth muscle leads to vasoconstriction. Less is known about ET-1 signaling in reptiles. In anaesthetized alligators, ET-1 elicits a biphasic blood pressure with a long-lasting initial decrease followed by a smaller increase in systemic blood pressure. In anaesthetized freshwater turtles, ET-1 causes a dose-dependent systemic vasodilatation mediated through ETB receptors. In the present study, we investigated the cardiovascular effects of ET-1 on the systemic and pulmonary vasculature of pythons. The presence of ETA and ETB receptors in the vasculature of pythons was verified by means of immunoblotting. Myography on isolated vessels revealed a dose-dependent vasoconstrictory response to ET-1 in both mesenteric and pulmonary arteries. Pressure measurements in recovered specimens revealed an ET-1-induced rise in systemic blood pressure supporting our in vitro findings. In conclusion, our study shows that ET-1 induces a strong pressor effect in the systemic circulation.

AB - Endothelin-1 (ET-1) is a very potent vasoactive peptide released from endothelial cells, and ET-1 plays an important role in the maintenance and regulation of blood pressure in mammals. ET-1 signaling is mediated by two receptors: ETA and ETB. In mammals, ETA receptors are located on vascular smooth muscle where they mediate vasoconstriction. ETB receptors located on the endothelium mediate vasodilatation through the release of nitric oxide, whereas stimulation of ETB receptors placed on vascular smooth muscle leads to vasoconstriction. Less is known about ET-1 signaling in reptiles. In anaesthetized alligators, ET-1 elicits a biphasic blood pressure with a long-lasting initial decrease followed by a smaller increase in systemic blood pressure. In anaesthetized freshwater turtles, ET-1 causes a dose-dependent systemic vasodilatation mediated through ETB receptors. In the present study, we investigated the cardiovascular effects of ET-1 on the systemic and pulmonary vasculature of pythons. The presence of ETA and ETB receptors in the vasculature of pythons was verified by means of immunoblotting. Myography on isolated vessels revealed a dose-dependent vasoconstrictory response to ET-1 in both mesenteric and pulmonary arteries. Pressure measurements in recovered specimens revealed an ET-1-induced rise in systemic blood pressure supporting our in vitro findings. In conclusion, our study shows that ET-1 induces a strong pressor effect in the systemic circulation.

KW - Blood pressure

KW - ET receptor

KW - Myography

KW - Reptile

UR - http://www.scopus.com/inward/record.url?scp=85076474790&partnerID=8YFLogxK

U2 - 10.1016/j.cbpa.2019.110620

DO - 10.1016/j.cbpa.2019.110620

M3 - Journal article

C2 - 31770594

AN - SCOPUS:85076474790

VL - 241

JO - Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology

JF - Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology

SN - 1095-6433

M1 - 110620

ER -