Endothelial Cell Metabolism: A potential target to improve tumor immunity

Olivia Lisa Wagman; Julie Nelly Christensen; Joanna Maria Kalucka

doi:10.1016/j.coisb.2021.100376

Endothelial Cell Metabolism: A potential target to improve tumor immunity

Olivia Lisa Wagman, Julie Nelly Christensen, Joanna Maria Kalucka^*

^*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

2 Citations (Scopus)

67 Downloads (Pure)

Abstract

Failure of current therapies to eliminate tumors is, in part, due to inadequate infiltration of immune cells. The importance of endothelial cells for the induction of immune responses is now being recognized. However, tumor endothelial cells (TECs) are dysfunctional, leading to decreased tumor immunity. Because TEC metabolism contributes to the abnormal vascular phenotype, interest is growing in the tumor vasculature as a target to improve immune responses. Recent insights into the relationship between TEC metabolism and immunity suggest that normalization of the tumor vasculature through metabolic reprogramming could be an important tool to improve immune-based anti-cancer therapies.

Original language	English
Article number	100376
Journal	Current Opinion in Systems Biology
Volume	28
ISSN	2452-3100
DOIs	https://doi.org/10.1016/j.coisb.2021.100376
Publication status	Published - Dec 2021

Keywords

Activation
Cancer
Endothelial cells
Immunoregulation
Inflammation
Metabolism

Access to Document

10.1016/j.coisb.2021.100376Licence: CC BY

1-s2.0-S2452310021000706-mainFinal published version, 1.31 MBLicence: CC BY

Library access?

Check availability with the Royal Danish Library

Cite this

@article{4faf5c55c6344d598a5e74c9f4200ceb,

title = "Endothelial Cell Metabolism: A potential target to improve tumor immunity",

abstract = "Failure of current therapies to eliminate tumors is, in part, due to inadequate infiltration of immune cells. The importance of endothelial cells for the induction of immune responses is now being recognized. However, tumor endothelial cells (TECs) are dysfunctional, leading to decreased tumor immunity. Because TEC metabolism contributes to the abnormal vascular phenotype, interest is growing in the tumor vasculature as a target to improve immune responses. Recent insights into the relationship between TEC metabolism and immunity suggest that normalization of the tumor vasculature through metabolic reprogramming could be an important tool to improve immune-based anti-cancer therapies.",

keywords = "Activation, Cancer, Endothelial cells, Immunoregulation, Inflammation, Metabolism",

author = "Wagman, \{Olivia Lisa\} and Christensen, \{Julie Nelly\} and Kalucka, \{Joanna Maria\}",

year = "2021",

month = dec,

doi = "10.1016/j.coisb.2021.100376",

language = "English",

volume = "28",

journal = "Current Opinion in Systems Biology",

issn = "2452-3100",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Endothelial Cell Metabolism

T2 - A potential target to improve tumor immunity

AU - Wagman, Olivia Lisa

AU - Christensen, Julie Nelly

AU - Kalucka, Joanna Maria

PY - 2021/12

Y1 - 2021/12

N2 - Failure of current therapies to eliminate tumors is, in part, due to inadequate infiltration of immune cells. The importance of endothelial cells for the induction of immune responses is now being recognized. However, tumor endothelial cells (TECs) are dysfunctional, leading to decreased tumor immunity. Because TEC metabolism contributes to the abnormal vascular phenotype, interest is growing in the tumor vasculature as a target to improve immune responses. Recent insights into the relationship between TEC metabolism and immunity suggest that normalization of the tumor vasculature through metabolic reprogramming could be an important tool to improve immune-based anti-cancer therapies.

AB - Failure of current therapies to eliminate tumors is, in part, due to inadequate infiltration of immune cells. The importance of endothelial cells for the induction of immune responses is now being recognized. However, tumor endothelial cells (TECs) are dysfunctional, leading to decreased tumor immunity. Because TEC metabolism contributes to the abnormal vascular phenotype, interest is growing in the tumor vasculature as a target to improve immune responses. Recent insights into the relationship between TEC metabolism and immunity suggest that normalization of the tumor vasculature through metabolic reprogramming could be an important tool to improve immune-based anti-cancer therapies.

KW - Activation

KW - Cancer

KW - Endothelial cells

KW - Immunoregulation

KW - Inflammation

KW - Metabolism

UR - http://www.scopus.com/inward/record.url?scp=85122671720&partnerID=8YFLogxK

U2 - 10.1016/j.coisb.2021.100376

DO - 10.1016/j.coisb.2021.100376

M3 - Journal article

SN - 2452-3100

VL - 28

JO - Current Opinion in Systems Biology

JF - Current Opinion in Systems Biology

M1 - 100376

ER -

Endothelial Cell Metabolism: A potential target to improve tumor immunity

Abstract

Keywords

Access to Document

Library access?

Other files and links

Fingerprint

Cite this