Aarhus University Seal

Endothelial cell heterogeneity and plasticity in health and disease—new insights from single-cell studies

Research output: Contribution to book/anthology/report/proceedingBook chapterResearchpeer-review

  • Lisa M. Becker, KU Leuven
  • ,
  • Alessandra Pasut, KU Leuven
  • ,
  • Anne Cuypers, KU Leuven
  • ,
  • Peter Carmeliet

The vascular endothelium is highly heterogeneous, with phenotypically and functionally distinct endothelial cell (EC) subtypes, partially driven by distinct metabolic programs. While this heterogeneity is important to maintain the multiple functions of the endothelium during tissue repair, it also contributes to challenges to therapeutically modulate ECs in pathological contexts. While the EC heterogeneity is far from being entirely unraveled, recent advances in single-cell technologies have greatly contributed to the identification of different EC subsets and cell states. In this chapter, we discuss new EC subsets captured by single-cell studies in health and disease, also focusing on metabolic EC signatures. We also highlight how such metabolic signatures could be exploited in therapeutic settings to promote or block angiogenesis.

Original languageEnglish
Title of host publicationThe Vasculome : From Many, One
EditorsZorina S. Galis
Number of pages12
Publication yearJan 2022
ISBN (print)9780128225479
ISBN (Electronic)9780128225462
Publication statusPublished - Jan 2022

    Research areas

  • Angiogenesis, Endothelial cells, Metabolism, Single-cell analyses, Tissue repair, Tumorigenesis

See relations at Aarhus University Citationformats

ID: 303750645