Enamides accessed from aminothioesters via a Pd(0)-catalyzed decarbonylative/β-hydride elimination sequence

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A facile synthesis of various enamides from aminothioesters via a palladium(0)-catalyzed decarbonylation/β-hydride elimination is reported. This protocol was applied to mercaptopyridyl C-terminal modified peptides for the generation of enamides without epimerization at stereogenic centers.
Original languageEnglish
JournalOrganic Letters
Volume12
Issue21
Pages (from-to)4716-4719
Number of pages4
ISSN1523-7060
DOIs
Publication statusPublished - 5 Nov 2010

    Research areas

  • Amines, Amino Acids, Biological Products, Biphenyl Compounds, Catalysis, Esters, Hydrogen, Imidazoles, Molecular Structure, Palladium, Sulfhydryl Compounds

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