Emerging regulation and functions of autophagy

Patricia Boya; Fulvio Reggiori; Patrice Codogno

doi:10.1038/ncb2788

Emerging regulation and functions of autophagy

Patricia Boya, Fulvio Reggiori, Patrice Codogno

Aarhus Institute of Advanced Studies

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

1009 Citations (Scopus)

Abstract

Autophagy maintains cell, tissue and organism homeostasis through degradation. Complex post-translational modulation of the Atg (autophagy-related) proteins adds additional entry points for crosstalk with other cellular processes and helps define cell-type-specific regulations of autophagy. Beyond the simplistic view of a process exclusively dedicated to the turnover of cellular components, recent data have uncovered unexpected functions for autophagy and the autophagy-related genes, such as regulation of metabolism, membrane transport and modulation of host defenses--indicating the novel frontiers lying ahead.

Original language	English
Journal	Nature Cell Biology
Volume	15
Issue	7
Pages (from-to)	713-20
Number of pages	8
ISSN	1465-7392
DOIs	https://doi.org/10.1038/ncb2788
Publication status	Published - Jul 2013

Keywords

Animals
Autophagy/physiology
Biological Transport
Host-Pathogen Interactions
Humans

Access to Document

10.1038/ncb2788

Cite this

@article{3374c9161bf24bff85ff27c5927bc8bf,

title = "Emerging regulation and functions of autophagy",

abstract = "Autophagy maintains cell, tissue and organism homeostasis through degradation. Complex post-translational modulation of the Atg (autophagy-related) proteins adds additional entry points for crosstalk with other cellular processes and helps define cell-type-specific regulations of autophagy. Beyond the simplistic view of a process exclusively dedicated to the turnover of cellular components, recent data have uncovered unexpected functions for autophagy and the autophagy-related genes, such as regulation of metabolism, membrane transport and modulation of host defenses--indicating the novel frontiers lying ahead.",

keywords = "Animals, Autophagy/physiology, Biological Transport, Host-Pathogen Interactions, Humans",

author = "Patricia Boya and Fulvio Reggiori and Patrice Codogno",

year = "2013",

month = jul,

doi = "10.1038/ncb2788",

language = "English",

volume = "15",

pages = "713--20",

journal = "Nature Cell Biology",

issn = "1465-7392",

publisher = "Nature Research",

number = "7",

}

TY - JOUR

T1 - Emerging regulation and functions of autophagy

AU - Boya, Patricia

AU - Reggiori, Fulvio

AU - Codogno, Patrice

PY - 2013/7

Y1 - 2013/7

N2 - Autophagy maintains cell, tissue and organism homeostasis through degradation. Complex post-translational modulation of the Atg (autophagy-related) proteins adds additional entry points for crosstalk with other cellular processes and helps define cell-type-specific regulations of autophagy. Beyond the simplistic view of a process exclusively dedicated to the turnover of cellular components, recent data have uncovered unexpected functions for autophagy and the autophagy-related genes, such as regulation of metabolism, membrane transport and modulation of host defenses--indicating the novel frontiers lying ahead.

AB - Autophagy maintains cell, tissue and organism homeostasis through degradation. Complex post-translational modulation of the Atg (autophagy-related) proteins adds additional entry points for crosstalk with other cellular processes and helps define cell-type-specific regulations of autophagy. Beyond the simplistic view of a process exclusively dedicated to the turnover of cellular components, recent data have uncovered unexpected functions for autophagy and the autophagy-related genes, such as regulation of metabolism, membrane transport and modulation of host defenses--indicating the novel frontiers lying ahead.

KW - Animals

KW - Autophagy/physiology

KW - Biological Transport

KW - Host-Pathogen Interactions

KW - Humans

U2 - 10.1038/ncb2788

DO - 10.1038/ncb2788

M3 - Review

C2 - 23817233

SN - 1465-7392

VL - 15

SP - 713

EP - 720

JO - Nature Cell Biology

JF - Nature Cell Biology

IS - 7

ER -

Emerging regulation and functions of autophagy

Abstract

Keywords

Access to Document

Fingerprint

Cite this