Electrospun Nanofibers of Natural and Synthetic Polymers as Artificial Extracellular Matrix for Tissue Engineering

Mina Keshvardoostchokami; Sara Seidelin Majidi; Peipei Huo; Rajan Ramachandran; Menglin Chen; Bo Liu

doi:10.3390/nano11010021

Electrospun Nanofibers of Natural and Synthetic Polymers as Artificial Extracellular Matrix for Tissue Engineering

Mina Keshvardoostchokami, Sara Seidelin Majidi, Peipei Huo, Rajan Ramachandran, Menglin Chen, Bo Liu^*

^*Corresponding author for this work

Interdisciplinary Nanoscience Center - INANO-Fysik, iNANO-huset

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

Abstract

Many types of polymer nanofibers have been introduced as artificial extracellular matrices. Their controllable properties, such as wettability, surface charge, transparency, elasticity, porosity and surface to volume proportion, have attracted much attention. Moreover, functionalizing polymers with other bioactive components could enable the engineering of microenvironments to host cells for regenerative medical applications. In the current brief review, we focus on the most recently cited electrospun nanofibrous polymeric scaffolds and divide them into five main categories: natural polymer-natural polymer composite, natural polymer-synthetic polymer composite, synthetic polymer-synthetic polymer composite, crosslinked polymers and reinforced polymers with inorganic materials. Then, we focus on their physiochemical, biological and mechanical features and discussed the capability and efficiency of the nanofibrous scaffolds to function as the extracellular matrix to support cellular function.

Original language	English
Article number	21
Journal	Nanomaterials
Volume	11
Issue	1
Pages (from-to)	1-23
Number of pages	23
ISSN	2079-4991
DOIs	https://doi.org/10.3390/nano11010021
Publication status	Published - Jan 2021

Keywords

Bioengineering
Electrospinning
Extracellular matrix
Nanofibers
Scaffold

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10.3390/nano11010021

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title = "Electrospun Nanofibers of Natural and Synthetic Polymers as Artificial Extracellular Matrix for Tissue Engineering",

abstract = "Many types of polymer nanofibers have been introduced as artificial extracellular matrices. Their controllable properties, such as wettability, surface charge, transparency, elasticity, porosity and surface to volume proportion, have attracted much attention. Moreover, functionalizing polymers with other bioactive components could enable the engineering of microenvironments to host cells for regenerative medical applications. In the current brief review, we focus on the most recently cited electrospun nanofibrous polymeric scaffolds and divide them into five main categories: natural polymer-natural polymer composite, natural polymer-synthetic polymer composite, synthetic polymer-synthetic polymer composite, crosslinked polymers and reinforced polymers with inorganic materials. Then, we focus on their physiochemical, biological and mechanical features and discussed the capability and efficiency of the nanofibrous scaffolds to function as the extracellular matrix to support cellular function.",

keywords = "Bioengineering, Electrospinning, Extracellular matrix, Nanofibers, Scaffold",

author = "Mina Keshvardoostchokami and Majidi, {Sara Seidelin} and Peipei Huo and Rajan Ramachandran and Menglin Chen and Bo Liu",

year = "2021",

month = jan,

doi = "10.3390/nano11010021",

language = "English",

volume = "11",

pages = "1--23",

journal = "Nanomaterials",

issn = "2079-4991",

publisher = "Multidisciplinary Digital Publishing Institute",

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Electrospun Nanofibers of Natural and Synthetic Polymers as Artificial Extracellular Matrix for Tissue Engineering. / Keshvardoostchokami, Mina; Majidi, Sara Seidelin; Huo, Peipei et al.
In: Nanomaterials, Vol. 11, No. 1, 21, 01.2021, p. 1-23.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Review › Research › peer-review

TY - JOUR

T1 - Electrospun Nanofibers of Natural and Synthetic Polymers as Artificial Extracellular Matrix for Tissue Engineering

AU - Keshvardoostchokami, Mina

AU - Majidi, Sara Seidelin

AU - Huo, Peipei

AU - Ramachandran, Rajan

AU - Chen, Menglin

AU - Liu, Bo

PY - 2021/1

Y1 - 2021/1

N2 - Many types of polymer nanofibers have been introduced as artificial extracellular matrices. Their controllable properties, such as wettability, surface charge, transparency, elasticity, porosity and surface to volume proportion, have attracted much attention. Moreover, functionalizing polymers with other bioactive components could enable the engineering of microenvironments to host cells for regenerative medical applications. In the current brief review, we focus on the most recently cited electrospun nanofibrous polymeric scaffolds and divide them into five main categories: natural polymer-natural polymer composite, natural polymer-synthetic polymer composite, synthetic polymer-synthetic polymer composite, crosslinked polymers and reinforced polymers with inorganic materials. Then, we focus on their physiochemical, biological and mechanical features and discussed the capability and efficiency of the nanofibrous scaffolds to function as the extracellular matrix to support cellular function.

AB - Many types of polymer nanofibers have been introduced as artificial extracellular matrices. Their controllable properties, such as wettability, surface charge, transparency, elasticity, porosity and surface to volume proportion, have attracted much attention. Moreover, functionalizing polymers with other bioactive components could enable the engineering of microenvironments to host cells for regenerative medical applications. In the current brief review, we focus on the most recently cited electrospun nanofibrous polymeric scaffolds and divide them into five main categories: natural polymer-natural polymer composite, natural polymer-synthetic polymer composite, synthetic polymer-synthetic polymer composite, crosslinked polymers and reinforced polymers with inorganic materials. Then, we focus on their physiochemical, biological and mechanical features and discussed the capability and efficiency of the nanofibrous scaffolds to function as the extracellular matrix to support cellular function.

KW - Bioengineering

KW - Electrospinning

KW - Extracellular matrix

KW - Nanofibers

KW - Scaffold

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U2 - 10.3390/nano11010021

DO - 10.3390/nano11010021

M3 - Review

C2 - 33374248

SN - 2079-4991

VL - 11

SP - 1

EP - 23

JO - Nanomaterials

JF - Nanomaterials

IS - 1

M1 - 21

ER -

Electrospun Nanofibers of Natural and Synthetic Polymers as Artificial Extracellular Matrix for Tissue Engineering

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Keywords

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