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Electron capture dissociation of weakly bound polypeptide polycationic complexes

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  • Kim F. Haselmann, Department of Chemistry, Odense University
  • ,
  • Thomas J. D. Jørgensen, Department of Biochemistry and Molecular Biology, University of Southern Danmark
  • ,
  • Bogdan A. Budnik, Department of Chemistry, Odense University
  • ,
  • F. Jensen
  • Roman A. Zubarev, Department of Chemistry, Odense University
We have previously reported that, in electron capture dissociation (ECD), rupture of strong intramolecular bonds in weakly bound supramolecular aggregates can proceed without dissociation of weak intermolecular bonds. This is now illustrated on a series of non-specific peptide-peptide dimers as well as specific complexes of modified glycopeptide antibiotics with their target peptide. The weak nature of bonding is substantiated by blackbody infrared dissociation, low-energy collisional excitation and force-field simulations. The results are consistent with a non-ergodic ECD cleavage mechanism.
Original languageEnglish
JournalRapid Communications in Mass Spectrometry
Pages (from-to)2260-2265
Number of pages6
Publication statusPublished - 2002
Externally publishedYes

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