Electroconvulsive stimulation reverses anhedonia and cognitive impairments in rats exposed to chronic mild stress

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Electroconvulsive stimulation reverses anhedonia and cognitive impairments in rats exposed to chronic mild stress. / Henningsen, K; Woldbye, D P D; Wiborg, O.

In: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, Vol. 23, No. 12, 12.2013, p. 1789-94.

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperJournal articleResearchpeer-review

Harvard

Henningsen, K, Woldbye, DPD & Wiborg, O 2013, 'Electroconvulsive stimulation reverses anhedonia and cognitive impairments in rats exposed to chronic mild stress', European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, vol. 23, no. 12, pp. 1789-94. https://doi.org/10.1016/j.euroneuro.2013.03.011

APA

Henningsen, K., Woldbye, D. P. D., & Wiborg, O. (2013). Electroconvulsive stimulation reverses anhedonia and cognitive impairments in rats exposed to chronic mild stress. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 23(12), 1789-94. https://doi.org/10.1016/j.euroneuro.2013.03.011

CBE

Henningsen K, Woldbye DPD, Wiborg O. 2013. Electroconvulsive stimulation reverses anhedonia and cognitive impairments in rats exposed to chronic mild stress. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 23(12):1789-94. https://doi.org/10.1016/j.euroneuro.2013.03.011

MLA

Henningsen, K, D P D Woldbye and O Wiborg. "Electroconvulsive stimulation reverses anhedonia and cognitive impairments in rats exposed to chronic mild stress". European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2013, 23(12). 1789-94. https://doi.org/10.1016/j.euroneuro.2013.03.011

Vancouver

Henningsen K, Woldbye DPD, Wiborg O. Electroconvulsive stimulation reverses anhedonia and cognitive impairments in rats exposed to chronic mild stress. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2013 Dec;23(12):1789-94. https://doi.org/10.1016/j.euroneuro.2013.03.011

Author

Henningsen, K ; Woldbye, D P D ; Wiborg, O. / Electroconvulsive stimulation reverses anhedonia and cognitive impairments in rats exposed to chronic mild stress. In: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2013 ; Vol. 23, No. 12. pp. 1789-94.

Bibtex

@article{0e6fa80bc3af4724b8c9597b738baeb3,
title = "Electroconvulsive stimulation reverses anhedonia and cognitive impairments in rats exposed to chronic mild stress",
abstract = "Electroconvulsive therapy remains the most effective treatment for depression including a fast onset of action. However, this therapeutic approach suffers from some potential drawbacks. In the acute phase this includes amnesia. Electroconvulsive stimulation (ECS) has previously been shown to reverse a depression-like state in the chronic mild stress model of depression (CMS), but the effect of ECS on cognition has not previously been investigated. In this study the CMS model was used to induce a depressive-like condition in rats. The study was designed to investigate the acute effect of ECS treatment on working memory and the chronic effect of repeated ECS treatments on depression-like behavior and working memory. The results indicated that, in the acute phase, ECS treatment induced a working memory deficit in healthy controls unexposed to stress, while repeated treatments reversed stress-induced decline in working memory, as well as recovering rats submitted to the CMS paradigm from the anhedonic-like state. Like in the clinical setting, a single ECS exposure was ineffective in inducing remission from a depression-like state.",
keywords = "Analysis of Variance, Animals, Attention, Chronic Disease, Cognition Disorders, Disease Models, Animal, Drinking, Electroconvulsive Therapy, Food Preferences, Male, Rats, Rats, Wistar, Stress, Psychological, Sucrose, Sweetening Agents, Journal Article",
author = "K Henningsen and Woldbye, {D P D} and O Wiborg",
note = "Copyright {\circledC} 2013 Elsevier B.V. and ECNP. All rights reserved.",
year = "2013",
month = "12",
doi = "10.1016/j.euroneuro.2013.03.011",
language = "English",
volume = "23",
pages = "1789--94",
journal = "European Neuropsychopharmacology",
issn = "0924-977X",
publisher = "Elsevier BV",
number = "12",

}

RIS

TY - JOUR

T1 - Electroconvulsive stimulation reverses anhedonia and cognitive impairments in rats exposed to chronic mild stress

AU - Henningsen, K

AU - Woldbye, D P D

AU - Wiborg, O

N1 - Copyright © 2013 Elsevier B.V. and ECNP. All rights reserved.

PY - 2013/12

Y1 - 2013/12

N2 - Electroconvulsive therapy remains the most effective treatment for depression including a fast onset of action. However, this therapeutic approach suffers from some potential drawbacks. In the acute phase this includes amnesia. Electroconvulsive stimulation (ECS) has previously been shown to reverse a depression-like state in the chronic mild stress model of depression (CMS), but the effect of ECS on cognition has not previously been investigated. In this study the CMS model was used to induce a depressive-like condition in rats. The study was designed to investigate the acute effect of ECS treatment on working memory and the chronic effect of repeated ECS treatments on depression-like behavior and working memory. The results indicated that, in the acute phase, ECS treatment induced a working memory deficit in healthy controls unexposed to stress, while repeated treatments reversed stress-induced decline in working memory, as well as recovering rats submitted to the CMS paradigm from the anhedonic-like state. Like in the clinical setting, a single ECS exposure was ineffective in inducing remission from a depression-like state.

AB - Electroconvulsive therapy remains the most effective treatment for depression including a fast onset of action. However, this therapeutic approach suffers from some potential drawbacks. In the acute phase this includes amnesia. Electroconvulsive stimulation (ECS) has previously been shown to reverse a depression-like state in the chronic mild stress model of depression (CMS), but the effect of ECS on cognition has not previously been investigated. In this study the CMS model was used to induce a depressive-like condition in rats. The study was designed to investigate the acute effect of ECS treatment on working memory and the chronic effect of repeated ECS treatments on depression-like behavior and working memory. The results indicated that, in the acute phase, ECS treatment induced a working memory deficit in healthy controls unexposed to stress, while repeated treatments reversed stress-induced decline in working memory, as well as recovering rats submitted to the CMS paradigm from the anhedonic-like state. Like in the clinical setting, a single ECS exposure was ineffective in inducing remission from a depression-like state.

KW - Analysis of Variance

KW - Animals

KW - Attention

KW - Chronic Disease

KW - Cognition Disorders

KW - Disease Models, Animal

KW - Drinking

KW - Electroconvulsive Therapy

KW - Food Preferences

KW - Male

KW - Rats

KW - Rats, Wistar

KW - Stress, Psychological

KW - Sucrose

KW - Sweetening Agents

KW - Journal Article

U2 - 10.1016/j.euroneuro.2013.03.011

DO - 10.1016/j.euroneuro.2013.03.011

M3 - Journal article

C2 - 23597878

VL - 23

SP - 1789

EP - 1794

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

SN - 0924-977X

IS - 12

ER -