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Abstract
The discovery of new molecular biomarkers of cancer during the last decades and the development of new diagnostic devices exploiting those have significantly contributed to the clinical analysis of cancer and to improve the outcomes. Among those, liquid biopsy sensors exploiting aptamers for the detection of cancer biomarkers in body fluids are useful and accurate tools for a fast and inexpensive non-invasive screening of population. The incorporation of aptamers in electrochemical sandwich biosensors using enzyme labels, a so-called ELASA, has demonstrated its utility to improve the detection schemes. In this review, we overview the existing ELASA assays for numerous cancer biomarkers as alternatives to the traditional ELISA and discuss their possibilities to reach the market, currently dominated by optical immunoassays. Graphical abstract: [Figure not available: see fulltext.]
Original language | English |
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Journal | Analytical and Bioanalytical Chemistry |
Volume | 415 |
Issue | 18 |
Pages (from-to) | 3831-3846 |
Number of pages | 16 |
ISSN | 1618-2642 |
DOIs | |
Publication status | Published - Jul 2023 |
Keywords
- Aptamer electrodes
- Cancer diagnostics
- ELASA
- Electroanalysis
- Electrochemical sensors
- Enzymes
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Dive into the research topics of 'Electrochemical ELASA: improving early cancer detection and monitoring'. Together they form a unique fingerprint.Projects
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Validating Serum Tests for Human Epidermal growth factor Receptor-2 for Precise Diagnosis and Stratification of Breast and Gastro-Oesophagal Cancers
Ferapontova, E. (Award holder)
01/05/2021 → 30/04/2025
Project: Research