Electrochemical ELASA: improving early cancer detection and monitoring

Ana Díaz-Fernández*, Elena E. Ferapontova

*Corresponding author for this work

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaperReviewResearchpeer-review

3 Citations (Scopus)

Abstract

The discovery of new molecular biomarkers of cancer during the last decades and the development of new diagnostic devices exploiting those have significantly contributed to the clinical analysis of cancer and to improve the outcomes. Among those, liquid biopsy sensors exploiting aptamers for the detection of cancer biomarkers in body fluids are useful and accurate tools for a fast and inexpensive non-invasive screening of population. The incorporation of aptamers in electrochemical sandwich biosensors using enzyme labels, a so-called ELASA, has demonstrated its utility to improve the detection schemes. In this review, we overview the existing ELASA assays for numerous cancer biomarkers as alternatives to the traditional ELISA and discuss their possibilities to reach the market, currently dominated by optical immunoassays. Graphical abstract: [Figure not available: see fulltext.]

Original languageEnglish
JournalAnalytical and Bioanalytical Chemistry
Volume415
Issue18
Pages (from-to)3831-3846
Number of pages16
ISSN1618-2642
DOIs
Publication statusPublished - Jul 2023

Keywords

  • Aptamer electrodes
  • Cancer diagnostics
  • ELASA
  • Electroanalysis
  • Electrochemical sensors
  • Enzymes

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