Electrochemical Analysis of Dopamine: Perspectives of Specific In Vivo Detection

Elena E. Ferapontova

doi:10.1016/j.electacta.2017.05.183

Electrochemical Analysis of Dopamine: Perspectives of Specific In Vivo Detection

^*Corresponding author for this work

Interdisciplinary Nanoscience Center - INANO-Kemi, iNANO-huset

Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Journal article › Research › peer-review

93 Citations (Scopus)

Abstract

Direct electrochemical analysis of in vivo levels of dopamine, whose metabolic transformation in the brain can be correlated with a number of neurodegenerative disorders such as Parkinson's and Alzheimer's diseases as well as psychosis and drug addiction, allows studying their mechanisms and the ways they can be treated. However, direct electrochemical analysis of dopamine can often be masked by electrochemical responses from structurally related neurotransmitters, dopamine precursors and products of its metabolic transformation, whose redox potentials overlap with those of dopamine. In this mini-review, the state-of-the-art in the field and recent trends in specific electroanalysis of dopamine in the presence of structurally related neurotransmitters are reviewed and critically discussed.

Original language	English
Journal	Electrochimica Acta
Volume	245
Pages (from-to)	664-671
Number of pages	8
ISSN	0013-4686
DOIs	https://doi.org/10.1016/j.electacta.2017.05.183
Publication status	Published - 10 Aug 2017

Keywords

Electroanalysis
dopamine
catechol amines
carbon microfiber electrodes
enzyme electrodes
aptamer electrodes
CARBON ELECTRODES
DROSOPHILA-MELANOGASTER
EXOCYTOTIC EVENTS
BIOGENIC-AMINES
BRAIN-TISSUE
RELEASE
MICROELECTRODES
VOLTAMMETRY
BIOSENSOR
NEUROTRANSMITTERS

Access to Document

10.1016/j.electacta.2017.05.183

Cite this

@article{27e9773420f3406fa76ef75581d52af3,

title = "Electrochemical Analysis of Dopamine: Perspectives of Specific In Vivo Detection",

abstract = "Direct electrochemical analysis of in vivo levels of dopamine, whose metabolic transformation in the brain can be correlated with a number of neurodegenerative disorders such as Parkinson's and Alzheimer's diseases as well as psychosis and drug addiction, allows studying their mechanisms and the ways they can be treated. However, direct electrochemical analysis of dopamine can often be masked by electrochemical responses from structurally related neurotransmitters, dopamine precursors and products of its metabolic transformation, whose redox potentials overlap with those of dopamine. In this mini-review, the state-of-the-art in the field and recent trends in specific electroanalysis of dopamine in the presence of structurally related neurotransmitters are reviewed and critically discussed.",

keywords = "Electroanalysis, dopamine, catechol amines, carbon microfiber electrodes, enzyme electrodes, aptamer electrodes, CARBON ELECTRODES, DROSOPHILA-MELANOGASTER, EXOCYTOTIC EVENTS, BIOGENIC-AMINES, BRAIN-TISSUE, RELEASE, MICROELECTRODES, VOLTAMMETRY, BIOSENSOR, NEUROTRANSMITTERS",

author = "Ferapontova, {Elena E.}",

year = "2017",

month = aug,

day = "10",

doi = "10.1016/j.electacta.2017.05.183",

language = "English",

volume = "245",

pages = "664--671",

journal = "Electrochimica Acta",

issn = "0013-4686",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Electrochemical Analysis of Dopamine

T2 - Perspectives of Specific In Vivo Detection

AU - Ferapontova, Elena E.

PY - 2017/8/10

Y1 - 2017/8/10

N2 - Direct electrochemical analysis of in vivo levels of dopamine, whose metabolic transformation in the brain can be correlated with a number of neurodegenerative disorders such as Parkinson's and Alzheimer's diseases as well as psychosis and drug addiction, allows studying their mechanisms and the ways they can be treated. However, direct electrochemical analysis of dopamine can often be masked by electrochemical responses from structurally related neurotransmitters, dopamine precursors and products of its metabolic transformation, whose redox potentials overlap with those of dopamine. In this mini-review, the state-of-the-art in the field and recent trends in specific electroanalysis of dopamine in the presence of structurally related neurotransmitters are reviewed and critically discussed.

AB - Direct electrochemical analysis of in vivo levels of dopamine, whose metabolic transformation in the brain can be correlated with a number of neurodegenerative disorders such as Parkinson's and Alzheimer's diseases as well as psychosis and drug addiction, allows studying their mechanisms and the ways they can be treated. However, direct electrochemical analysis of dopamine can often be masked by electrochemical responses from structurally related neurotransmitters, dopamine precursors and products of its metabolic transformation, whose redox potentials overlap with those of dopamine. In this mini-review, the state-of-the-art in the field and recent trends in specific electroanalysis of dopamine in the presence of structurally related neurotransmitters are reviewed and critically discussed.

KW - Electroanalysis

KW - dopamine

KW - catechol amines

KW - carbon microfiber electrodes

KW - enzyme electrodes

KW - aptamer electrodes

KW - CARBON ELECTRODES

KW - DROSOPHILA-MELANOGASTER

KW - EXOCYTOTIC EVENTS

KW - BIOGENIC-AMINES

KW - BRAIN-TISSUE

KW - RELEASE

KW - MICROELECTRODES

KW - VOLTAMMETRY

KW - BIOSENSOR

KW - NEUROTRANSMITTERS

UR - http://www.scopus.com/inward/record.url?scp=85020284668&partnerID=8YFLogxK

U2 - 10.1016/j.electacta.2017.05.183

DO - 10.1016/j.electacta.2017.05.183

M3 - Journal article

SN - 0013-4686

VL - 245

SP - 664

EP - 671

JO - Electrochimica Acta

JF - Electrochimica Acta

ER -

Electrochemical Analysis of Dopamine: Perspectives of Specific In Vivo Detection

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this