Since the first attempts by Europeans to penetrate Greenland's interior, its geometric center, Eismitte (‘middle ice’), has been one of the most forbidding but scientifically rich locations in the Arctic. Tracing its history from European contact through the Cold War, this study shows how Eismitte was a setting for scientific knowledge production as well as diplomatic maneuvering, providing new insights into the history of polar exploration and the intertwining of scientific and geopolitical considerations. Author Janet Martin-Nielsen draws on new research in private, government, military, and institutional archives in many languages in multiple countries to illuminate Eismitte’s place in the scientific imagination.