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Efficient clustering of identity-by-descent between multiple individuals

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  • Yu Qian
  • ,
  • Brian L Browning
  • ,
  • Sharon R Browning
Most existing identity-by-descent (IBD) detection methods only consider haplotype pairs; less attention has been paid to considering multiple haplotypes simultaneously, even though IBD is an equivalence relation on haplotypes that partitions a set of haplotypes into IBD clusters. Multiple-haplotype IBD clusters may have advantages over pairwise IBD in some applications, such as IBD mapping. Existing methods for detecting multiple-haplotype IBD clusters are often computationally expensive and unable to handle large samples with thousands of haplotypes.
Original languageEnglish
Pages (from-to) 915-922
Publication statusPublished - 12 Jan 2014

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