TY - JOUR
T1 - Effects of mindfulness-based stress reduction on neuropeptide Y plasma levels in stressed individuals
AU - Østergaard, Helle Degnbol
AU - Pallesen, Karen Johanne
AU - Nielsen, Marit Nyholm
AU - Fjorback, Lone
AU - Juul, Lise
AU - Winterdahl, Michael
N1 - Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.
PY - 2025/1
Y1 - 2025/1
N2 - BACKGROUND: Clinical studies have suggested that dysregulation of the neuropeptide Y (NPY) system may play a role in psychiatric disorders, including chronic stress. Meanwhile, Mindfulness Based Stress Reduction (MBSR) has shown promise for stress-related maladies. However, no studies have explored whether MBSR can change plasma NPY concentration in stressed individuals.METHOD: Individuals with symptoms of chronic stress were randomly assigned to eight weeks of either MBSR (n = 15), a locally-developed stress reduction intervention (LSR) (n = 15) or a wait-list control group (n = 20). Blood samples were collected at baseline and at a twelve-week follow-up to determine the effects of MBSR or LSR compared to the wait-list control group on NPY levels.RESULTS: The MBSR group had increased plasma NPY levels after the program compared to the waitlist control group, whereas the LSR group was not statistically different from the other groups.CONCLUSION: This pilot study provides evidence of the feasibility of MBSR to alter plasma NPY.
AB - BACKGROUND: Clinical studies have suggested that dysregulation of the neuropeptide Y (NPY) system may play a role in psychiatric disorders, including chronic stress. Meanwhile, Mindfulness Based Stress Reduction (MBSR) has shown promise for stress-related maladies. However, no studies have explored whether MBSR can change plasma NPY concentration in stressed individuals.METHOD: Individuals with symptoms of chronic stress were randomly assigned to eight weeks of either MBSR (n = 15), a locally-developed stress reduction intervention (LSR) (n = 15) or a wait-list control group (n = 20). Blood samples were collected at baseline and at a twelve-week follow-up to determine the effects of MBSR or LSR compared to the wait-list control group on NPY levels.RESULTS: The MBSR group had increased plasma NPY levels after the program compared to the waitlist control group, whereas the LSR group was not statistically different from the other groups.CONCLUSION: This pilot study provides evidence of the feasibility of MBSR to alter plasma NPY.
KW - Mindfulness
KW - Neuropeptide Y
KW - Occupational stress
UR - http://www.scopus.com/inward/record.url?scp=85211088274&partnerID=8YFLogxK
U2 - 10.1016/j.jpsychires.2024.12.011
DO - 10.1016/j.jpsychires.2024.12.011
M3 - Journal article
C2 - 39657564
SN - 0022-3956
VL - 181
SP - 400
EP - 404
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
ER -